Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation ATM

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
DR1up-regulatesR-45-0.00173773Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

SREBF1up-regulatesR-11390.101608Pr-7
PLAG1down-regulatesR-15220.140759Pr-93
SPIBup-regulatesR-670-0.26844Pr-92
ETS1up-regulatesR-5-0.284036Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

MAFGup-regulatesR-1490-0.300169Pr-58
SPIBup-regulatesR-6610.39364Pr-85
MAFup-regulatesR-1020.468356Pr-88
ENSG00000176887up-regulatesR-18990.507358Pr-50
NFATC2up-regulatesR-16880.551677Pr-85
SMAD3up-regulatesR-2962-0.592902Pr-122
MYBup-regulatesR-6150.668149Pr-85
FLI1down-regulatesR-786-0.733394Pr-59
SMAD3up-regulatesR-2960-0.759716Pr-90
SREBF1up-regulatesR-11370.963749Pr-87
NFATC2up-regulatesR-1696-1.01601Pr-99
MYBup-regulatesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ETS1up-regulatesR-131.07999Pr-93
HMGA1down-regulatesR-8331.0818Pr-58
FLI1down-regulatesR-7881.22051Pr-7
HMGA1down-regulatesR-8261.24266Pr-93
ETV6up-regulatesR-698-1.25265Pr-37
SPIBup-regulatesR-6641.32468Pr-87
SMAD3up-regulatesR-29631.44668Pr-120
NR3C1up-regulatesR-3193-1.45371Pr-86
MAFup-regulatesR-1041.49044Pr-88
MAFup-regulatesR-1011.56978Pr-87
NFATC2up-regulatesR-1690-1.61477Pr-88
MYBup-regulatesR-6171.6152Pr-87
MYBup-regulatesR-6231.65419Pr-96
SREBF1up-regulatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

HMGA1down-regulatesR-8201.79517Pr-87
MYBup-regulatesR-622-1.933Pr-85
HMGA1down-regulatesR-824-1.97932Pr-91
SMAD3up-regulatesR-2967-1.98807Pr-139
SPIBup-regulatesR-668-2.41677Pr-90
FLI1down-regulatesR-7932.52326Pr-96
ZBTB7Bup-regulatesR-12332.59774Pr-52
ETS1up-regulatesR-92.77231Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PEBP1up-regulatesR-17552.80711Pr-1
ETV2down-regulatesR-1507-2.80802Pr-36
ENSG00000175832up-regulatesR-313-2.85877Pr-101
ELK4up-regulatesR-766-2.86246Pr-36
PLAG1down-regulatesR-1528-2.89171Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ETV6up-regulatesR-694-2.92866Pr-118
NR3C1up-regulatesR-3180-2.95291Pr-94
MAFGup-regulatesR-14932.9536Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

MAFGup-regulatesR-14943.01778Pr-21
PEBP1up-regulatesR-17543.03268Pr-87
ENSG00000175832up-regulatesR-312-3.06Pr-36
FLI1down-regulatesR-780-3.11957Pr-36
JDP2up-regulatesR-357-3.22307Pr-94
ETV6up-regulatesR-710-3.28784Pr-38
SPIBup-regulatesR-6783.32159Pr-87
MYBup-regulatesR-620-3.37541Pr-38
PEBP1up-regulatesR-1752-3.39081Pr-36
SMAD3up-regulatesR-2959-3.47323Pr-15
SPIBup-regulatesR-6733.97206Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

SPIBup-regulatesR-6674.06751Pr-48
ENSG00000176887up-regulatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

NFATC2up-regulatesR-1692-4.70958Pr-135
MAFup-regulatesR-1065.50825Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

ENSG00000176399up-regulatesR-10717.79759Pr-71

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions