Program

Causal Mechanistic Flows with regulons in program Pr-52

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesMAFKrepressesR-28110.1235718Pr-52
t(11;14)down-regulatesZEB1activatesR-22501.462629Pr-52
amp1qup-regulatesZEB1activatesR-22501.462629Pr-52
del13up-regulatesZEB1activatesR-22501.462629Pr-52
t(11;14)_cytogeneticdown-regulatesZEB1activatesR-22501.462629Pr-52
EGR1down-regulatesZNF740repressesR-3841.9811811Pr-52
FLGdown-regulatesZNF740repressesR-3841.9811811Pr-52
IRF4up-regulatesZNF740repressesR-3841.9811811Pr-52
KIAA1109down-regulatesZNF740repressesR-3841.9811811Pr-52
MUC12down-regulatesZNF740repressesR-3841.9811811Pr-52
OBSCNdown-regulatesZNF740repressesR-3841.9811811Pr-52
PCLOdown-regulatesZNF740repressesR-3841.9811811Pr-52
RELNdown-regulatesZNF740repressesR-3841.9811811Pr-52
t(11;14)up-regulatesZNF740repressesR-3841.9811811Pr-52
RNASeq_CCND3_Callup-regulatesZNF740repressesR-3841.9811811Pr-52
RNASeq_FGFR3_Calldown-regulatesZNF740repressesR-3841.9811811Pr-52
RNASeq_MAFA_Calldown-regulatesZNF740repressesR-3841.9811811Pr-52
t(14;16)down-regulatesZNF740repressesR-3841.9811811Pr-52
t(4;14)down-regulatesZNF740repressesR-3841.9811811Pr-52
ROBO1down-regulatesZNF740repressesR-3841.9811811Pr-52
SP140down-regulatesZNF740repressesR-3841.9811811Pr-52
TTNdown-regulatesZNF740repressesR-3841.9811811Pr-52
amp1qdown-regulatesZNF740repressesR-3841.9811811Pr-52
del13down-regulatesZNF740repressesR-3841.9811811Pr-52
t(11;14)_cytogeneticup-regulatesZNF740repressesR-3841.9811811Pr-52
t(14;16)_cytogeneticdown-regulatesZNF740repressesR-3841.9811811Pr-52
t(4;14)_cytogeneticdown-regulatesZNF740repressesR-3841.9811811Pr-52
AHNAK2up-regulatesZBTB7BactivatesR-12332.597747Pr-52
ATMup-regulatesZBTB7BactivatesR-12332.597747Pr-52
DIS3up-regulatesZBTB7BactivatesR-12332.597747Pr-52
FGFR3up-regulatesZBTB7BactivatesR-12332.597747Pr-52
MUC12up-regulatesZBTB7BactivatesR-12332.597747Pr-52
NRASdown-regulatesZBTB7BactivatesR-12332.597747Pr-52
PCLOup-regulatesZBTB7BactivatesR-12332.597747Pr-52
RELNup-regulatesZBTB7BactivatesR-12332.597747Pr-52
t(11;14)down-regulatesZBTB7BactivatesR-12332.597747Pr-52
RNASeq_FGFR3_Callup-regulatesZBTB7BactivatesR-12332.597747Pr-52
RNASeq_MAFA_Callup-regulatesZBTB7BactivatesR-12332.597747Pr-52
RNASeq_MAFB_Callup-regulatesZBTB7BactivatesR-12332.597747Pr-52
t(14;16)up-regulatesZBTB7BactivatesR-12332.597747Pr-52
t(4;14)up-regulatesZBTB7BactivatesR-12332.597747Pr-52
TRAF3up-regulatesZBTB7BactivatesR-12332.597747Pr-52
TTNup-regulatesZBTB7BactivatesR-12332.597747Pr-52
amp1qup-regulatesZBTB7BactivatesR-12332.597747Pr-52
del13up-regulatesZBTB7BactivatesR-12332.597747Pr-52
t(11;14)_cytogeneticdown-regulatesZBTB7BactivatesR-12332.597747Pr-52
t(14;16)_cytogeneticup-regulatesZBTB7BactivatesR-12332.597747Pr-52
t(4;14)_cytogeneticup-regulatesZBTB7BactivatesR-12332.597747Pr-52
DNAH5down-regulatesRFX3repressesR-16612.9216713Pr-52
DSTdown-regulatesRFX3repressesR-16612.9216713Pr-52
MUC12down-regulatesRFX3repressesR-16612.9216713Pr-52
t(11;14)up-regulatesRFX3repressesR-16612.9216713Pr-52
TRAF3down-regulatesRFX3repressesR-16612.9216713Pr-52
t(11;14)_cytogeneticup-regulatesRFX3repressesR-16612.9216713Pr-52
DIS3up-regulatesENSG00000087510activatesR-26292.9465512Pr-52
FGFR3up-regulatesENSG00000087510activatesR-26292.9465512Pr-52
NRASdown-regulatesENSG00000087510activatesR-26292.9465512Pr-52
PCLOup-regulatesENSG00000087510activatesR-26292.9465512Pr-52
PRDM1up-regulatesENSG00000087510activatesR-26292.9465512Pr-52
t(11;14)down-regulatesENSG00000087510activatesR-26292.9465512Pr-52
RNASeq_FGFR3_Callup-regulatesENSG00000087510activatesR-26292.9465512Pr-52
RNASeq_MAFB_Callup-regulatesENSG00000087510activatesR-26292.9465512Pr-52
t(14;16)up-regulatesENSG00000087510activatesR-26292.9465512Pr-52
t(4;14)up-regulatesENSG00000087510activatesR-26292.9465512Pr-52
amp1qup-regulatesENSG00000087510activatesR-26292.9465512Pr-52
del13up-regulatesENSG00000087510activatesR-26292.9465512Pr-52
del1pup-regulatesENSG00000087510activatesR-26292.9465512Pr-52
t(11;14)_cytogeneticdown-regulatesENSG00000087510activatesR-26292.9465512Pr-52
t(4;14)_cytogeneticup-regulatesENSG00000087510activatesR-26292.9465512Pr-52
FAT1down-regulatesENSG00000165066repressesR-30773.3183412Pr-52
LTBdown-regulatesENSG00000165066repressesR-30773.3183412Pr-52
t(11;14)up-regulatesENSG00000165066repressesR-30773.3183412Pr-52
RNASeq_FGFR3_Calldown-regulatesENSG00000165066repressesR-30773.3183412Pr-52
t(14;16)down-regulatesENSG00000165066repressesR-30773.3183412Pr-52
t(4;14)down-regulatesENSG00000165066repressesR-30773.3183412Pr-52
amp1qdown-regulatesENSG00000165066repressesR-30773.3183412Pr-52
del13down-regulatesENSG00000165066repressesR-30773.3183412Pr-52
t(11;14)_cytogeneticup-regulatesENSG00000165066repressesR-30773.3183412Pr-52
FAT1up-regulatesDLX4activatesR-19863.400598Pr-52
FGFR3up-regulatesDLX4activatesR-19863.400598Pr-52
LTBup-regulatesDLX4activatesR-19863.400598Pr-52
NRASdown-regulatesDLX4activatesR-19863.400598Pr-52
PRKD2up-regulatesDLX4activatesR-19863.400598Pr-52
t(11;14)down-regulatesDLX4activatesR-19863.400598Pr-52
RNASeq_FGFR3_Callup-regulatesDLX4activatesR-19863.400598Pr-52
t(4;14)up-regulatesDLX4activatesR-19863.400598Pr-52
amp1qup-regulatesDLX4activatesR-19863.400598Pr-52
del13up-regulatesDLX4activatesR-19863.400598Pr-52
del1pup-regulatesDLX4activatesR-19863.400598Pr-52
t(11;14)_cytogeneticdown-regulatesDLX4activatesR-19863.400598Pr-52
t(4;14)_cytogeneticup-regulatesDLX4activatesR-19863.400598Pr-52
DIS3down-regulatesPAX6repressesR-15483.5890815Pr-52
FGFR3down-regulatesPAX6repressesR-15483.5890815Pr-52
RNASeq_FGFR3_Calldown-regulatesPAX6repressesR-15483.5890815Pr-52
t(14;16)down-regulatesPAX6repressesR-15483.5890815Pr-52
t(4;14)down-regulatesPAX6repressesR-15483.5890815Pr-52
amp1qdown-regulatesPAX6repressesR-15483.5890815Pr-52
del13down-regulatesPAX6repressesR-15483.5890815Pr-52
t(4;14)_cytogeneticdown-regulatesPAX6repressesR-15483.5890815Pr-52
RNASeq_FGFR3_Callup-regulatesSTAT3activatesR-3053.5951914Pr-52
t(14;16)up-regulatesSTAT3activatesR-3053.5951914Pr-52
t(4;14)up-regulatesSTAT3activatesR-3053.5951914Pr-52
amp1qup-regulatesSTAT3activatesR-3053.5951914Pr-52
del13up-regulatesSTAT3activatesR-3053.5951914Pr-52
t(11;14)_cytogeneticdown-regulatesSTAT3activatesR-3053.5951914Pr-52
t(4;14)_cytogeneticup-regulatesSTAT3activatesR-3053.5951914Pr-52
AHNAK2down-regulatesELF1repressesR-29783.7758919Pr-52
DSTdown-regulatesELF1repressesR-29783.7758919Pr-52
NRASup-regulatesELF1repressesR-29783.7758919Pr-52
t(11;14)up-regulatesELF1repressesR-29783.7758919Pr-52
TRAF3down-regulatesELF1repressesR-29783.7758919Pr-52
t(11;14)_cytogeneticup-regulatesELF1repressesR-29783.7758919Pr-52
DCHS1up-regulatesMEF2DactivatesR-8703.8216815Pr-52
DIS3up-regulatesMEF2DactivatesR-8703.8216815Pr-52
FGFR3up-regulatesMEF2DactivatesR-8703.8216815Pr-52
LTBup-regulatesMEF2DactivatesR-8703.8216815Pr-52
OBSCNup-regulatesMEF2DactivatesR-8703.8216815Pr-52
PCLOup-regulatesMEF2DactivatesR-8703.8216815Pr-52
t(11;14)down-regulatesMEF2DactivatesR-8703.8216815Pr-52
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-8703.8216815Pr-52
RNASeq_MAFB_Callup-regulatesMEF2DactivatesR-8703.8216815Pr-52
t(14;16)up-regulatesMEF2DactivatesR-8703.8216815Pr-52
t(4;14)up-regulatesMEF2DactivatesR-8703.8216815Pr-52
TTNup-regulatesMEF2DactivatesR-8703.8216815Pr-52
amp1qup-regulatesMEF2DactivatesR-8703.8216815Pr-52
del13up-regulatesMEF2DactivatesR-8703.8216815Pr-52
t(11;14)_cytogeneticdown-regulatesMEF2DactivatesR-8703.8216815Pr-52
t(4;14)_cytogeneticup-regulatesMEF2DactivatesR-8703.8216815Pr-52
AHNAK2up-regulatesSP1activatesR-27163.8892832Pr-52
DCHS1up-regulatesSP1activatesR-27163.8892832Pr-52
FGFR3up-regulatesSP1activatesR-27163.8892832Pr-52
PCDH15down-regulatesSP1activatesR-27163.8892832Pr-52
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27163.8892832Pr-52
RNASeq_MAFA_Callup-regulatesSP1activatesR-27163.8892832Pr-52
RNASeq_MAFB_Callup-regulatesSP1activatesR-27163.8892832Pr-52
t(14;16)up-regulatesSP1activatesR-27163.8892832Pr-52
t(4;14)up-regulatesSP1activatesR-27163.8892832Pr-52
ROBO2up-regulatesSP1activatesR-27163.8892832Pr-52
TRAF3up-regulatesSP1activatesR-27163.8892832Pr-52
TTNup-regulatesSP1activatesR-27163.8892832Pr-52
amp1qup-regulatesSP1activatesR-27163.8892832Pr-52
t(14;16)_cytogeneticup-regulatesSP1activatesR-27163.8892832Pr-52
t(4;14)_cytogeneticup-regulatesSP1activatesR-27163.8892832Pr-52
AHNAK2up-regulatesMAZactivatesR-4964.1534623Pr-52
DCHS1up-regulatesMAZactivatesR-4964.1534623Pr-52
DIS3up-regulatesMAZactivatesR-4964.1534623Pr-52
FGFR3up-regulatesMAZactivatesR-4964.1534623Pr-52
MUC12up-regulatesMAZactivatesR-4964.1534623Pr-52
NRASdown-regulatesMAZactivatesR-4964.1534623Pr-52
RELNup-regulatesMAZactivatesR-4964.1534623Pr-52
RNASeq_FGFR3_Callup-regulatesMAZactivatesR-4964.1534623Pr-52
RNASeq_MAFB_Callup-regulatesMAZactivatesR-4964.1534623Pr-52
t(14;16)up-regulatesMAZactivatesR-4964.1534623Pr-52
t(4;14)up-regulatesMAZactivatesR-4964.1534623Pr-52
TTNup-regulatesMAZactivatesR-4964.1534623Pr-52
amp1qup-regulatesMAZactivatesR-4964.1534623Pr-52
del13up-regulatesMAZactivatesR-4964.1534623Pr-52
t(14;16)_cytogeneticup-regulatesMAZactivatesR-4964.1534623Pr-52
t(4;14)_cytogeneticup-regulatesMAZactivatesR-4964.1534623Pr-52

Regulons in program Pr-52

Regulon Cox Hazard Ratio # genes # causal flows
R-28110.12357181
R-22501.4626294
R-3841.981181122
R-12332.59774721
R-16612.92167136
R-26292.946551215
R-30773.31834129
R-19863.40059813
R-15483.58908158
R-3053.59519147
R-29783.77589196
R-8703.821681516
R-27163.889283215
R-4964.153462316

Genes in program Pr-52

EnsEMBL IdEntrez IdPreferred
ENSG00000176399
ENSG00000198862 26046LTN1
ENSG00000228716 1719DHFR

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions