Program

Causal Mechanistic Flows with regulons in program Pr-53

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FGFR3up-regulatesENSG00000178860activatesR-11010.1427586Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_FGFR3_Callup-regulatesENSG00000178860activatesR-11010.1427586Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(14;16)up-regulatesENSG00000178860activatesR-11010.1427586Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)up-regulatesENSG00000178860activatesR-11010.1427586Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qup-regulatesENSG00000178860activatesR-11010.1427586Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)_cytogeneticup-regulatesENSG00000178860activatesR-11010.1427586Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

ATMup-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

NRASdown-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_MAFB_Callup-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(14;16)up-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)up-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qup-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13up-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)_cytogeneticup-regulatesMAFGactivatesR-14932.95367Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

DMDdown-regulatesNFE2L2repressesR-19133.008738Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_CCND2_Callup-regulatesNFE2L2repressesR-19133.008738Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qdown-regulatesNFE2L2repressesR-19133.008738Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13down-regulatesNFE2L2repressesR-19133.008738Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del1pdown-regulatesNFE2L2repressesR-19133.008738Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(11;14)up-regulatesFOXJ3activatesR-28903.9584114Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-28903.9584114Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)up-regulatesFOXJ3activatesR-28903.9584114Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qup-regulatesFOXJ3activatesR-28903.9584114Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13up-regulatesFOXJ3activatesR-28903.9584114Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

ATMup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

DCHS1up-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

DIS3up-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

FAM46Cdown-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

NRASdown-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

PRDM1up-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_FGFR3_Callup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_MAFB_Callup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(14;16)up-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)up-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

TRIOup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13up-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del1pup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)_cytogeneticup-regulatesSPIBactivatesR-6733.9720610Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

DIS3up-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

FGFR3up-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_FGFR3_Callup-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(14;16)up-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)up-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qup-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13up-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del1pup-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)_cytogeneticup-regulatesPRDM1activatesR-20854.220779Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

DIS3up-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

FGFR3up-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

LTBup-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

PRDM1up-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

PRKD2up-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_FGFR3_Callup-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_MAFA_Callup-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)up-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13up-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)_cytogeneticup-regulatesYY1activatesR-25244.4887412Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

AHNAK2up-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

DIS3up-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

FAM46Cdown-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

FGFR3up-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

NRASdown-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

PRKD2up-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_FGFR3_Callup-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_MAFA_Callup-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

RNASeq_MAFB_Callup-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(14;16)up-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)up-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

TRIOup-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

amp1qup-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

del13up-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(14;16)_cytogeneticup-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

t(4;14)_cytogeneticup-regulatesMAZactivatesR-5045.1131111Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

Regulons in program Pr-53

Regulon Cox Hazard Ratio # genes # causal flows
R-11010.14275866
R-14932.953678
R-19133.0087385
R-28903.95841145
R-6733.972061016
R-20854.2207799
R-25244.488741210
R-5045.113111116

Genes in program Pr-53

EnsEMBL IdEntrez IdPreferred
ENSG00000176624 51320MEX3C

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions