Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

MEF2A - myocyte enhancer factor 2A

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4205 ENSG00000068305 MEF2A H0YKY6

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: MEF2A

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2MEF2ArepressesR-18760.111678Pr-137
DCHS1MEF2ArepressesR-18760.111678Pr-137
FAM46CMEF2ArepressesR-18760.111678Pr-137
FAT3MEF2ArepressesR-18760.111678Pr-137
MAXMEF2ArepressesR-18760.111678Pr-137
NRASMEF2ArepressesR-18760.111678Pr-137
PTPRDMEF2ArepressesR-18760.111678Pr-137
RNASeq_CCND2_CallMEF2ArepressesR-18760.111678Pr-137
RNASeq_FGFR3_CallMEF2ArepressesR-18760.111678Pr-137
t(4;14)MEF2ArepressesR-18760.111678Pr-137
TACC2MEF2ArepressesR-18760.111678Pr-137
TACC2MEF2AactivatesR-18840.142343Pr-23
amp1qMEF2AactivatesR-18840.142343Pr-23
del13MEF2AactivatesR-18840.142343Pr-23
amp1qMEF2AactivatesR-18700.206143Pr-29
del13MEF2AactivatesR-18700.206143Pr-29
AHNAK2MEF2AactivatesR-1869-0.397022Pr-2
FAT3MEF2AactivatesR-1869-0.397022Pr-2
MACF1MEF2AactivatesR-1869-0.397022Pr-2
MYO10MEF2AactivatesR-1869-0.397022Pr-2
RNASeq_MAFB_CallMEF2AactivatesR-1869-0.397022Pr-2
SYNE1MEF2AactivatesR-1869-0.397022Pr-2
TACC2MEF2AactivatesR-1869-0.397022Pr-2
amp1qMEF2AactivatesR-1869-0.397022Pr-2
del13MEF2AactivatesR-1869-0.397022Pr-2
AHNAK2MEF2AactivatesR-1866-0.518528Pr-3
MACF1MEF2AactivatesR-1866-0.518528Pr-3
MAGI1MEF2AactivatesR-1866-0.518528Pr-3
MAXMEF2AactivatesR-1866-0.518528Pr-3
MYO10MEF2AactivatesR-1866-0.518528Pr-3
PTPRDMEF2AactivatesR-1866-0.518528Pr-3
RNASeq_MAFA_CallMEF2AactivatesR-1866-0.518528Pr-3
RNASeq_MAFB_CallMEF2AactivatesR-1866-0.518528Pr-3
SYNE1MEF2AactivatesR-1866-0.518528Pr-3
TACC2MEF2AactivatesR-1866-0.518528Pr-3
del13MEF2AactivatesR-1866-0.518528Pr-3
DCHS1MEF2ArepressesR-18860.552959Pr-129
DIS3MEF2ArepressesR-18860.552959Pr-129
FAM46CMEF2ArepressesR-18860.552959Pr-129
MAXMEF2ArepressesR-18860.552959Pr-129
NRASMEF2ArepressesR-18860.552959Pr-129
PTPRDMEF2ArepressesR-18860.552959Pr-129
RNASeq_CCND2_CallMEF2ArepressesR-18860.552959Pr-129
RNASeq_FGFR3_CallMEF2ArepressesR-18860.552959Pr-129
t(4;14)MEF2ArepressesR-18860.552959Pr-129
SETD2MEF2ArepressesR-18860.552959Pr-129
t(14;16)_cytogeneticMEF2ArepressesR-18860.552959Pr-129
DCHS1MEF2ArepressesR-18720.561055Pr-56
FAM46CMEF2ArepressesR-18720.561055Pr-56
MAXMEF2ArepressesR-18720.561055Pr-56
NRASMEF2ArepressesR-18720.561055Pr-56
PTPRDMEF2ArepressesR-18720.561055Pr-56
RNASeq_FGFR3_CallMEF2ArepressesR-18720.561055Pr-56
RNASeq_MAFB_CallMEF2ArepressesR-18720.561055Pr-56
t(4;14)MEF2ArepressesR-18720.561055Pr-56
SYNE1MEF2ArepressesR-18720.561055Pr-56
t(14;16)_cytogeneticMEF2ArepressesR-18720.561055Pr-56
AHNAK2MEF2AactivatesR-1865-0.617403Pr-6
KALRNMEF2AactivatesR-1865-0.617403Pr-6
MAGI1MEF2AactivatesR-1865-0.617403Pr-6
TACC2MEF2AactivatesR-1865-0.617403Pr-6
amp1qMEF2AactivatesR-1865-0.617403Pr-6
del13MEF2AactivatesR-1865-0.617403Pr-6
amp1qMEF2AactivatesR-18830.684037Pr-18
del13MEF2AactivatesR-18830.684037Pr-18
DIS3MEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

FAM46CMEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

MAXMEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

NRASMEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RNASeq_FGFR3_CallMEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RNASeq_MAFA_CallMEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RNASeq_MAFB_CallMEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

t(4;14)MEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

t(14;16)_cytogeneticMEF2ArepressesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

amp1qMEF2AactivatesR-18790.89332Pr-7
del13MEF2AactivatesR-18790.89332Pr-7
MAGI1MEF2AactivatesR-18641.08745Pr-1
TACC2MEF2AactivatesR-18641.08745Pr-1
amp1qMEF2AactivatesR-18641.08745Pr-1
del13MEF2AactivatesR-18641.08745Pr-1
AHNAK2MEF2AactivatesR-1878-1.24921Pr-9
DCHS1MEF2AactivatesR-1878-1.24921Pr-9
DIS3MEF2AactivatesR-1878-1.24921Pr-9
FAT3MEF2AactivatesR-1878-1.24921Pr-9
MACF1MEF2AactivatesR-1878-1.24921Pr-9
MAGI1MEF2AactivatesR-1878-1.24921Pr-9
MAXMEF2AactivatesR-1878-1.24921Pr-9
MYO10MEF2AactivatesR-1878-1.24921Pr-9
NRASMEF2AactivatesR-1878-1.24921Pr-9
PTPRDMEF2AactivatesR-1878-1.24921Pr-9
RNASeq_CCND2_CallMEF2AactivatesR-1878-1.24921Pr-9
RNASeq_FGFR3_CallMEF2AactivatesR-1878-1.24921Pr-9
RNASeq_MAFA_CallMEF2AactivatesR-1878-1.24921Pr-9
RNASeq_MAFB_CallMEF2AactivatesR-1878-1.24921Pr-9
t(4;14)MEF2AactivatesR-1878-1.24921Pr-9
TACC2MEF2AactivatesR-1878-1.24921Pr-9
t(14;16)_cytogeneticMEF2AactivatesR-1878-1.24921Pr-9
amp1qMEF2AactivatesR-1882-1.26851Pr-24
AHNAK2MEF2AactivatesR-18711.35384Pr-16
RNASeq_CCND2_CallMEF2AactivatesR-18711.35384Pr-16
TACC2MEF2AactivatesR-18711.35384Pr-16
amp1qMEF2AactivatesR-18711.35384Pr-16
del13MEF2AactivatesR-18711.35384Pr-16
AHNAK2MEF2AactivatesR-1888-1.38486Pr-22
MYO10MEF2AactivatesR-1888-1.38486Pr-22
PTPRDMEF2AactivatesR-1888-1.38486Pr-22
RNASeq_MAFB_CallMEF2AactivatesR-1888-1.38486Pr-22
SYNE1MEF2AactivatesR-1888-1.38486Pr-22
DCHS1MEF2ArepressesR-1885-2.09865Pr-89
DIS3MEF2ArepressesR-1885-2.09865Pr-89
FAM46CMEF2ArepressesR-1885-2.09865Pr-89
KALRNMEF2ArepressesR-1885-2.09865Pr-89
NRASMEF2ArepressesR-1885-2.09865Pr-89
RNASeq_MAFA_CallMEF2ArepressesR-1885-2.09865Pr-89
RNASeq_MAFB_CallMEF2ArepressesR-1885-2.09865Pr-89
t(4;14)MEF2ArepressesR-1885-2.09865Pr-89
t(14;16)_cytogeneticMEF2ArepressesR-1885-2.09865Pr-89
AHNAK2MEF2AactivatesR-18812.39457Pr-21
MYO10MEF2AactivatesR-18812.39457Pr-21
PTPRDMEF2AactivatesR-18812.39457Pr-21
RNASeq_MAFA_CallMEF2AactivatesR-18812.39457Pr-21
SYNE1MEF2AactivatesR-18812.39457Pr-21
amp1qMEF2AactivatesR-18812.39457Pr-21
del13MEF2AactivatesR-18812.39457Pr-21
AHNAK2MEF2AactivatesR-1867-2.61348Pr-86
FAT3MEF2AactivatesR-1867-2.61348Pr-86
MAXMEF2AactivatesR-1867-2.61348Pr-86
RNASeq_CCND2_CallMEF2AactivatesR-1867-2.61348Pr-86
amp1qMEF2AactivatesR-1867-2.61348Pr-86
del13MEF2AactivatesR-1867-2.61348Pr-86
MACF1MEF2AactivatesR-1887-2.70745Pr-60
NRASMEF2AactivatesR-1887-2.70745Pr-60
SYNE1MEF2AactivatesR-1887-2.70745Pr-60
del13MEF2AactivatesR-1887-2.70745Pr-60
t(14;16)_cytogeneticMEF2AactivatesR-1887-2.70745Pr-60
AHNAK2MEF2AactivatesR-1877-3.20022Pr-38
DIS3MEF2AactivatesR-1877-3.20022Pr-38
FAM46CMEF2AactivatesR-1877-3.20022Pr-38
FAT3MEF2AactivatesR-1877-3.20022Pr-38
MACF1MEF2AactivatesR-1877-3.20022Pr-38
MAXMEF2AactivatesR-1877-3.20022Pr-38
NRASMEF2AactivatesR-1877-3.20022Pr-38
PTPRDMEF2AactivatesR-1877-3.20022Pr-38
RNASeq_FGFR3_CallMEF2AactivatesR-1877-3.20022Pr-38
RNASeq_MAFA_CallMEF2AactivatesR-1877-3.20022Pr-38
RNASeq_MAFB_CallMEF2AactivatesR-1877-3.20022Pr-38
t(4;14)MEF2AactivatesR-1877-3.20022Pr-38
SETD2MEF2AactivatesR-1877-3.20022Pr-38
t(14;16)_cytogeneticMEF2AactivatesR-1877-3.20022Pr-38
DCHS1MEF2ArepressesR-1874-3.26785Pr-135
MYO10MEF2ArepressesR-1874-3.26785Pr-135
RNASeq_MAFA_CallMEF2ArepressesR-1874-3.26785Pr-135
RNASeq_MAFB_CallMEF2ArepressesR-1874-3.26785Pr-135
amp1qMEF2ArepressesR-1874-3.26785Pr-135
del13MEF2ArepressesR-1874-3.26785Pr-135
t(14;16)_cytogeneticMEF2ArepressesR-1874-3.26785Pr-135
DIS3MEF2AactivatesR-1868-3.37401Pr-100
FAM46CMEF2AactivatesR-1868-3.37401Pr-100
NRASMEF2AactivatesR-1868-3.37401Pr-100
RNASeq_FGFR3_CallMEF2AactivatesR-1868-3.37401Pr-100
RNASeq_MAFA_CallMEF2AactivatesR-1868-3.37401Pr-100
t(4;14)MEF2AactivatesR-1868-3.37401Pr-100
SETD2MEF2AactivatesR-1868-3.37401Pr-100
AHNAK2MEF2ArepressesR-18804.46094Pr-128
DCHS1MEF2ArepressesR-18804.46094Pr-128
DIS3MEF2ArepressesR-18804.46094Pr-128
FAM46CMEF2ArepressesR-18804.46094Pr-128
FAT3MEF2ArepressesR-18804.46094Pr-128
MACF1MEF2ArepressesR-18804.46094Pr-128
MAXMEF2ArepressesR-18804.46094Pr-128
NRASMEF2ArepressesR-18804.46094Pr-128
RNASeq_CCND2_CallMEF2ArepressesR-18804.46094Pr-128
RNASeq_FGFR3_CallMEF2ArepressesR-18804.46094Pr-128
RNASeq_MAFA_CallMEF2ArepressesR-18804.46094Pr-128
RNASeq_MAFB_CallMEF2ArepressesR-18804.46094Pr-128
t(4;14)MEF2ArepressesR-18804.46094Pr-128
SETD2MEF2ArepressesR-18804.46094Pr-128
t(14;16)_cytogeneticMEF2ArepressesR-18804.46094Pr-128
AHNAK2MEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

DCHS1MEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

DIS3MEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FAM46CMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FAT3MEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MACF1MEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAXMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

NRASMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

PTPRDMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_FGFR3_CallMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_MAFA_CallMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_MAFB_CallMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)MEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SETD2MEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(14;16)_cytogeneticMEF2ArepressesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.