Program

Causal Mechanistic Flows with regulons in program Pr-18

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CMYA5down-regulatesNF1activatesR-127-0.223057Pr-18
DNAH5down-regulatesNF1activatesR-127-0.223057Pr-18
IRF4up-regulatesNF1activatesR-127-0.223057Pr-18
t(11;14)up-regulatesNF1activatesR-127-0.223057Pr-18
MYCdown-regulatesNF1activatesR-127-0.223057Pr-18
TP53down-regulatesNF1activatesR-127-0.223057Pr-18
del17down-regulatesNF1activatesR-127-0.223057Pr-18
t(11;14)_cytogeneticup-regulatesNF1activatesR-127-0.223057Pr-18
MACF1down-regulatesFOXO1activatesR-14060.49978217Pr-18
t(11;14)up-regulatesFOXO1activatesR-14060.49978217Pr-18
TACC2down-regulatesFOXO1activatesR-14060.49978217Pr-18
del13up-regulatesFOXO1activatesR-14060.49978217Pr-18
amp1qup-regulatesMEF2AactivatesR-18830.68403717Pr-18
del13up-regulatesMEF2AactivatesR-18830.68403717Pr-18
ABCA13down-regulatesPOU2F1activatesR-890.79668618Pr-18
CMYA5down-regulatesPOU2F1activatesR-890.79668618Pr-18
KALRNdown-regulatesPOU2F1activatesR-890.79668618Pr-18
MACF1down-regulatesPOU2F1activatesR-890.79668618Pr-18
t(11;14)up-regulatesPOU2F1activatesR-890.79668618Pr-18
TACC2down-regulatesPOU2F1activatesR-890.79668618Pr-18
amp1qup-regulatesPOU2F1activatesR-890.79668618Pr-18
del13up-regulatesPOU2F1activatesR-890.79668618Pr-18
t(11;14)_cytogeneticup-regulatesPOU2F1activatesR-890.79668618Pr-18
CMYA5up-regulatesHOXA3repressesR-2210.84910715Pr-18
DCHS1down-regulatesHOXA3repressesR-2210.84910715Pr-18
DIS3down-regulatesHOXA3repressesR-2210.84910715Pr-18
FAM46Cup-regulatesHOXA3repressesR-2210.84910715Pr-18
HUWE1down-regulatesHOXA3repressesR-2210.84910715Pr-18
IRF4down-regulatesHOXA3repressesR-2210.84910715Pr-18
NEBup-regulatesHOXA3repressesR-2210.84910715Pr-18
PRKD2down-regulatesHOXA3repressesR-2210.84910715Pr-18
t(11;14)down-regulatesHOXA3repressesR-2210.84910715Pr-18
RNASeq_FGFR3_Calldown-regulatesHOXA3repressesR-2210.84910715Pr-18
t(14;16)down-regulatesHOXA3repressesR-2210.84910715Pr-18
t(4;14)down-regulatesHOXA3repressesR-2210.84910715Pr-18
del17pup-regulatesHOXA3repressesR-2210.84910715Pr-18
t(11;14)_cytogeneticdown-regulatesHOXA3repressesR-2210.84910715Pr-18
t(4;14)_cytogeneticdown-regulatesHOXA3repressesR-2210.84910715Pr-18
t(11;14)up-regulatesFOXJ2activatesR-14400.92636617Pr-18
t(14;16)up-regulatesFOXJ2activatesR-14400.92636617Pr-18
t(4;14)up-regulatesFOXJ2activatesR-14400.92636617Pr-18
amp1qup-regulatesFOXJ2activatesR-14400.92636617Pr-18
del13up-regulatesFOXJ2activatesR-14400.92636617Pr-18
RNASeq_MAFA_Callup-regulatesARID5AactivatesR-6041.060158Pr-18
t(14;16)up-regulatesARID5AactivatesR-6041.060158Pr-18
amp1qup-regulatesARID5AactivatesR-6041.060158Pr-18
del13up-regulatesARID5AactivatesR-6041.060158Pr-18
CMYA5down-regulatesHMBOX1activatesR-23851.119276Pr-18
DMDup-regulatesHMBOX1activatesR-23851.119276Pr-18
FGFR3up-regulatesHMBOX1activatesR-23851.119276Pr-18
MACF1down-regulatesHMBOX1activatesR-23851.119276Pr-18
t(11;14)up-regulatesHMBOX1activatesR-23851.119276Pr-18
t(11;14)_cytogeneticup-regulatesHMBOX1activatesR-23851.119276Pr-18
IRF4down-regulatesPOU2F2repressesR-25151.1803710Pr-18
t(11;14)down-regulatesPOU2F2repressesR-25151.1803710Pr-18
t(14;16)down-regulatesPOU2F2repressesR-25151.1803710Pr-18
t(11;14)_cytogeneticdown-regulatesPOU2F2repressesR-25151.1803710Pr-18
DIS3up-regulatesSATB1activatesR-10761.331111Pr-18
FGFR3up-regulatesSATB1activatesR-10761.331111Pr-18
PRKD2up-regulatesSATB1activatesR-10761.331111Pr-18
RNASeq_FGFR3_Callup-regulatesSATB1activatesR-10761.331111Pr-18
t(4;14)up-regulatesSATB1activatesR-10761.331111Pr-18
t(4;14)_cytogeneticup-regulatesSATB1activatesR-10761.331111Pr-18
CMYA5down-regulatesRARAactivatesR-1651.5966910Pr-18
MACF1down-regulatesRARAactivatesR-1651.5966910Pr-18
t(11;14)up-regulatesRARAactivatesR-1651.5966910Pr-18
SYNE1down-regulatesRARAactivatesR-1651.5966910Pr-18
TACC2down-regulatesRARAactivatesR-1651.5966910Pr-18
del13up-regulatesRARAactivatesR-1651.5966910Pr-18
t(11;14)_cytogeneticup-regulatesRARAactivatesR-1651.5966910Pr-18
DIS3down-regulatesEGR1repressesR-28993.6340411Pr-18
FGFR3down-regulatesEGR1repressesR-28993.6340411Pr-18
PRKD2down-regulatesEGR1repressesR-28993.6340411Pr-18
t(11;14)down-regulatesEGR1repressesR-28993.6340411Pr-18
RNASeq_FGFR3_Calldown-regulatesEGR1repressesR-28993.6340411Pr-18
t(4;14)down-regulatesEGR1repressesR-28993.6340411Pr-18
t(4;14)_cytogeneticdown-regulatesEGR1repressesR-28993.6340411Pr-18
RNASeq_MAFA_Callup-regulatesZEB1activatesR-22463.6762310Pr-18
t(14;16)up-regulatesZEB1activatesR-22463.6762310Pr-18
amp1qup-regulatesZEB1activatesR-22463.6762310Pr-18
del13up-regulatesZEB1activatesR-22463.6762310Pr-18
del1pup-regulatesZEB1activatesR-22463.6762310Pr-18
DIS3up-regulatesSP1activatesR-27314.2924215Pr-18
FAM46Cdown-regulatesSP1activatesR-27314.2924215Pr-18
FGFR3up-regulatesSP1activatesR-27314.2924215Pr-18
IRF4up-regulatesSP1activatesR-27314.2924215Pr-18
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27314.2924215Pr-18
RNASeq_MAFA_Callup-regulatesSP1activatesR-27314.2924215Pr-18
RNASeq_MAFB_Callup-regulatesSP1activatesR-27314.2924215Pr-18
t(14;16)up-regulatesSP1activatesR-27314.2924215Pr-18
t(4;14)up-regulatesSP1activatesR-27314.2924215Pr-18
TRIOup-regulatesSP1activatesR-27314.2924215Pr-18
amp1qup-regulatesSP1activatesR-27314.2924215Pr-18
t(4;14)_cytogeneticup-regulatesSP1activatesR-27314.2924215Pr-18
DIS3up-regulatesRFX3activatesR-16714.709387Pr-18
FAM46Cdown-regulatesRFX3activatesR-16714.709387Pr-18
FGFR3up-regulatesRFX3activatesR-16714.709387Pr-18
IRF4up-regulatesRFX3activatesR-16714.709387Pr-18
PRKD2up-regulatesRFX3activatesR-16714.709387Pr-18
t(11;14)up-regulatesRFX3activatesR-16714.709387Pr-18
RNASeq_FGFR3_Callup-regulatesRFX3activatesR-16714.709387Pr-18
t(4;14)up-regulatesRFX3activatesR-16714.709387Pr-18
t(11;14)_cytogeneticup-regulatesRFX3activatesR-16714.709387Pr-18
t(4;14)_cytogeneticup-regulatesRFX3activatesR-16714.709387Pr-18

Regulons in program Pr-18

Regulon Cox Hazard Ratio # genes # causal flows
R-127-0.2230578
R-14060.499782174
R-18830.684037172
R-890.796686189
R-2210.8491071515
R-14400.926366175
R-6041.0601584
R-23851.1192766
R-25151.18037104
R-10761.3311116
R-1651.59669107
R-28993.63404117
R-22463.67623105
R-27314.292421512
R-16714.70938710

Genes in program Pr-18

EnsEMBL IdEntrez IdPreferred
ENSG00000177519 56475RPRM
ENSG00000181274 23401FRAT2
ENSG00000184178 152579SCFD2
ENSG00000185480 55010PARPBP
ENSG00000186074
ENSG00000187134
ENSG00000189007 134637ADAT2
ENSG00000196388 388324INCA1
ENSG00000196954 837CASP4
ENSG00000198171 65992DDRGK1
ENSG00000204580 780DDR1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions