Program

Causal Mechanistic Flows with regulons in program Pr-6

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
MAGI1down-regulatesNFAT5activatesR-460.004895959Pr-6
NEBdown-regulatesNFAT5activatesR-460.004895959Pr-6
t(11;14)up-regulatesNFAT5activatesR-460.004895959Pr-6
t(14;16)up-regulatesSTAT4activatesR-26480.026767922Pr-6
t(4;14)up-regulatesSTAT4activatesR-26480.026767922Pr-6
AHNAK2down-regulatesNR3C1activatesR-3177-0.181326Pr-6
t(14;16)up-regulatesNR3C1activatesR-3177-0.181326Pr-6
del13up-regulatesNR3C1activatesR-3177-0.181326Pr-6
t(14;16)up-regulatesMEF2DactivatesR-869-0.20302716Pr-6
amp1qup-regulatesMEF2DactivatesR-869-0.20302716Pr-6
del13up-regulatesMEF2DactivatesR-869-0.20302716Pr-6
ABCA13up-regulatesEGR1repressesR-2895-0.2724927Pr-6
t(11;14)down-regulatesEGR1repressesR-2895-0.2724927Pr-6
ABCA13up-regulatesNR1H3repressesR-640.2982610Pr-6
RNASeq_FGFR3_Calldown-regulatesNR1H3repressesR-640.2982610Pr-6
t(14;16)down-regulatesNR1H3repressesR-640.2982610Pr-6
t(4;14)down-regulatesNR1H3repressesR-640.2982610Pr-6
amp1qdown-regulatesNR1H3repressesR-640.2982610Pr-6
del13down-regulatesNR1H3repressesR-640.2982610Pr-6
MAGI1down-regulatesBHLHE40activatesR-940-0.30230611Pr-6
t(11;14)up-regulatesBHLHE40activatesR-940-0.30230611Pr-6
LTBup-regulatesZFXactivatesR-1917-0.44648936Pr-6
RNASeq_FGFR3_Callup-regulatesZFXactivatesR-1917-0.44648936Pr-6
t(14;16)up-regulatesZFXactivatesR-1917-0.44648936Pr-6
MYCdown-regulatesZFXactivatesR-1917-0.44648936Pr-6
t(4;14)up-regulatesZFXactivatesR-1917-0.44648936Pr-6
amp1qup-regulatesZFXactivatesR-1917-0.44648936Pr-6
del13up-regulatesZFXactivatesR-1917-0.44648936Pr-6
t(4;14)_cytogeneticup-regulatesZFXactivatesR-1917-0.44648936Pr-6
AHNAK2down-regulatesFOXP1activatesR-3120-0.46769337Pr-6
t(11;14)up-regulatesFOXP1activatesR-3120-0.46769337Pr-6
t(14;16)up-regulatesFOXP1activatesR-3120-0.46769337Pr-6
TACC2down-regulatesFOXP1activatesR-3120-0.46769337Pr-6
amp1qup-regulatesFOXP1activatesR-3120-0.46769337Pr-6
del13up-regulatesFOXP1activatesR-3120-0.46769337Pr-6
AHNAK2down-regulatesCEBPGactivatesR-435-0.49794520Pr-6
ASXL3down-regulatesCEBPGactivatesR-435-0.49794520Pr-6
KALRNdown-regulatesCEBPGactivatesR-435-0.49794520Pr-6
MAGI1down-regulatesCEBPGactivatesR-435-0.49794520Pr-6
TACC2down-regulatesCEBPGactivatesR-435-0.49794520Pr-6
amp1qup-regulatesCEBPGactivatesR-435-0.49794520Pr-6
del13up-regulatesCEBPGactivatesR-435-0.49794520Pr-6
ASXL3down-regulatesETV6activatesR-697-0.54275916Pr-6
t(14;16)up-regulatesETV6activatesR-697-0.54275916Pr-6
t(4;14)up-regulatesETV6activatesR-697-0.54275916Pr-6
amp1qup-regulatesETV6activatesR-697-0.54275916Pr-6
del13up-regulatesETV6activatesR-697-0.54275916Pr-6
t(14;16)up-regulatesSMAD3activatesR-2958-0.58293619Pr-6
amp1qup-regulatesSMAD3activatesR-2958-0.58293619Pr-6
del13up-regulatesSMAD3activatesR-2958-0.58293619Pr-6
t(11;14)up-regulatesTFEBactivatesR-886-0.59196310Pr-6
AHNAK2down-regulatesMEF2AactivatesR-1865-0.61740341Pr-6
KALRNdown-regulatesMEF2AactivatesR-1865-0.61740341Pr-6
MAGI1down-regulatesMEF2AactivatesR-1865-0.61740341Pr-6
TACC2down-regulatesMEF2AactivatesR-1865-0.61740341Pr-6
amp1qup-regulatesMEF2AactivatesR-1865-0.61740341Pr-6
del13up-regulatesMEF2AactivatesR-1865-0.61740341Pr-6
del13down-regulatesCENPXrepressesR-2783-0.6289056Pr-6
ASXL3down-regulatesFOXO1activatesR-1396-0.66888137Pr-6
MAGI1down-regulatesFOXO1activatesR-1396-0.66888137Pr-6
TACC2down-regulatesFOXO1activatesR-1396-0.66888137Pr-6
del13up-regulatesFOXO1activatesR-1396-0.66888137Pr-6
ABCA13down-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
AHNAK2down-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
ASXL3down-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
MAGI1down-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
t(11;14)up-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
t(14;16)up-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
TACC2down-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
amp1qup-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
del13up-regulatesFOXJ2activatesR-1420-0.71887443Pr-6
del1pup-regulatesENSG00000179348activatesR-1057-0.72536714Pr-6
ABCA13down-regulatesFOXO3activatesR-2768-0.72560935Pr-6
ABCA13up-regulatesTCF3repressesR-2047-0.73318847Pr-6
t(14;16)down-regulatesTCF3repressesR-2047-0.73318847Pr-6
del13up-regulatesYY1activatesR-2528-0.7408487Pr-6
MAGI1down-regulatesSPI1activatesR-2603-0.74605544Pr-6
t(14;16)up-regulatesTFE3activatesR-557-0.7826747Pr-6
amp1qup-regulatesTFE3activatesR-557-0.7826747Pr-6
del13up-regulatesTFE3activatesR-557-0.7826747Pr-6
t(14;16)up-regulatesIRF1activatesR-178-0.80326436Pr-6
ABCA13down-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
AHNAK2down-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
ASXL3down-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
MAGI1down-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
t(11;14)up-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
TACC2down-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
amp1qup-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
del13up-regulatesFOXJ3activatesR-2874-0.86463842Pr-6
ABCA13down-regulatesPOU2F1activatesR-70-0.91122345Pr-6
AHNAK2down-regulatesPOU2F1activatesR-70-0.91122345Pr-6
MAGI1down-regulatesPOU2F1activatesR-70-0.91122345Pr-6
t(11;14)up-regulatesPOU2F1activatesR-70-0.91122345Pr-6
TACC2down-regulatesPOU2F1activatesR-70-0.91122345Pr-6
amp1qup-regulatesPOU2F1activatesR-70-0.91122345Pr-6
del13up-regulatesPOU2F1activatesR-70-0.91122345Pr-6
AHNAK2down-regulatesRREB1activatesR-2298-1.112279Pr-6
PRKD2down-regulatesRREB1activatesR-2298-1.112279Pr-6
RNASeq_MAFA_Calldown-regulatesRREB1activatesR-2298-1.112279Pr-6
TACC2down-regulatesRREB1activatesR-2298-1.112279Pr-6
TP53down-regulatesRREB1activatesR-2298-1.112279Pr-6
AHNAK2down-regulatesELF4activatesR-2329-1.1176638Pr-6
t(14;16)up-regulatesELF4activatesR-2329-1.1176638Pr-6
t(11;14)up-regulatesEWSR1activatesR-2561-1.241277Pr-6
TACC2down-regulatesEWSR1activatesR-2561-1.241277Pr-6
del13up-regulatesEWSR1activatesR-2561-1.241277Pr-6
t(11;14)_cytogeneticup-regulatesEWSR1activatesR-2561-1.241277Pr-6
t(11;14)up-regulatesELK1activatesR-651-1.706697Pr-6
t(14;16)up-regulatesELK1activatesR-651-1.706697Pr-6
TACC2down-regulatesELK1activatesR-651-1.706697Pr-6
amp1qup-regulatesELK1activatesR-651-1.706697Pr-6
del13up-regulatesELK1activatesR-651-1.706697Pr-6
AHNAK2down-regulatesHBP1activatesR-1845-2.400097Pr-6
DNAH5down-regulatesHBP1activatesR-1845-2.400097Pr-6
KALRNdown-regulatesHBP1activatesR-1845-2.400097Pr-6
MACF1down-regulatesHBP1activatesR-1845-2.400097Pr-6
t(11;14)up-regulatesHBP1activatesR-1845-2.400097Pr-6
TACC2down-regulatesHBP1activatesR-1845-2.400097Pr-6
del13up-regulatesHBP1activatesR-1845-2.400097Pr-6

Regulons in program Pr-6

Regulon Cox Hazard Ratio # genes # causal flows
R-460.0048959593
R-26480.0267679222
R-3177-0.1813263
R-869-0.203027163
R-2895-0.27249272
R-640.29826106
R-940-0.302306112
R-1917-0.446489368
R-3120-0.467693376
R-435-0.497945207
R-697-0.542759165
R-2958-0.582936193
R-886-0.591963101
R-1865-0.617403416
R-2783-0.62890561
R-1396-0.668881374
R-1420-0.718874439
R-1057-0.725367141
R-2768-0.725609351
R-2047-0.733188472
R-2528-0.74084871
R-2603-0.746055441
R-557-0.78267473
R-178-0.803264361
R-2874-0.864638428
R-70-0.911223457
R-2298-1.1122795
R-2329-1.11766382
R-2561-1.2412774
R-651-1.7066975
R-1845-2.4000977

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions