Program

Causal Mechanistic Flows with regulons in program Pr-135

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
RNASeq_FGFR3_Callup-regulatesSTAT3repressesR-311-0.07311426Pr-135
t(14;16)up-regulatesSTAT3repressesR-311-0.07311426Pr-135
MYCdown-regulatesSTAT3repressesR-311-0.07311426Pr-135
t(4;14)up-regulatesSTAT3repressesR-311-0.07311426Pr-135
TACC2down-regulatesSTAT3repressesR-311-0.07311426Pr-135
TP53down-regulatesSTAT3repressesR-311-0.07311426Pr-135
del13up-regulatesSTAT3repressesR-311-0.07311426Pr-135
t(4;14)_cytogeneticup-regulatesSTAT3repressesR-311-0.07311426Pr-135
DNAH10down-regulatesRREB1repressesR-2304-0.1038237Pr-135
MACF1down-regulatesRREB1repressesR-2304-0.1038237Pr-135
MXRA5down-regulatesRREB1repressesR-2304-0.1038237Pr-135
RNASeq_MAFA_Calldown-regulatesRREB1repressesR-2304-0.1038237Pr-135
TP53down-regulatesRREB1repressesR-2304-0.1038237Pr-135
NEBdown-regulatesARID5ArepressesR-610-0.1701276Pr-135
TACC2down-regulatesARID5ArepressesR-610-0.1701276Pr-135
del13up-regulatesARID5ArepressesR-610-0.1701276Pr-135
amp1qup-regulatesELF2repressesR-973-0.6157812Pr-135
del13up-regulatesELF2repressesR-973-0.6157812Pr-135
FGFR3up-regulatesRUNX3repressesR-901-0.6324416Pr-135
IRF4up-regulatesRUNX3repressesR-901-0.6324416Pr-135
PRKD2up-regulatesRUNX3repressesR-901-0.6324416Pr-135
t(11;14)up-regulatesRUNX3repressesR-901-0.6324416Pr-135
RNASeq_FGFR3_Callup-regulatesRUNX3repressesR-901-0.6324416Pr-135
t(14;16)up-regulatesRUNX3repressesR-901-0.6324416Pr-135
t(11;14)_cytogeneticup-regulatesRUNX3repressesR-901-0.6324416Pr-135
FAT3up-regulatesVBP1activatesR-21030.6381396Pr-135
KDM3Bup-regulatesVBP1activatesR-21030.6381396Pr-135
SVILup-regulatesVBP1activatesR-21030.6381396Pr-135
FAM46Cdown-regulatesETV5repressesR-341-0.7527018Pr-135
t(11;14)up-regulatesETV5repressesR-341-0.7527018Pr-135
MYCdown-regulatesETV5repressesR-341-0.7527018Pr-135
t(4;14)up-regulatesETV5repressesR-341-0.7527018Pr-135
XIRP2down-regulatesETV5repressesR-341-0.7527018Pr-135
del13up-regulatesETV5repressesR-341-0.7527018Pr-135
t(11;14)_cytogeneticup-regulatesETV5repressesR-341-0.7527018Pr-135
PCDH10down-regulatesETV6repressesR-717-0.8255558Pr-135
RNASeq_FGFR3_Callup-regulatesETV6repressesR-717-0.8255558Pr-135
t(4;14)up-regulatesETV6repressesR-717-0.8255558Pr-135
amp1qup-regulatesETV6repressesR-717-0.8255558Pr-135
del13up-regulatesETV6repressesR-717-0.8255558Pr-135
t(4;14)_cytogeneticup-regulatesETV6repressesR-717-0.8255558Pr-135
TP53down-regulatesRREB1repressesR-2293-0.86220515Pr-135
CYLDdown-regulatesTCF3activatesR-2067-0.87355511Pr-135
RNASeq_MAFA_Calldown-regulatesTCF3activatesR-2067-0.87355511Pr-135
t(14;16)down-regulatesTCF3activatesR-2067-0.87355511Pr-135
FAT3down-regulatesERFrepressesR-3370.9131736Pr-135
MACF1down-regulatesERFrepressesR-3370.9131736Pr-135
RNASeq_MAFA_Calldown-regulatesERFrepressesR-3370.9131736Pr-135
SETD2down-regulatesERFrepressesR-3370.9131736Pr-135
SYNE1down-regulatesERFrepressesR-3370.9131736Pr-135
TACC2down-regulatesERFrepressesR-3370.9131736Pr-135
del13up-regulatesERFrepressesR-3370.9131736Pr-135
t(14;16)_cytogeneticdown-regulatesERFrepressesR-3370.9131736Pr-135
BRAFdown-regulatesGABPAactivatesR-1454-1.0066513Pr-135
PCDH7up-regulatesGABPAactivatesR-1454-1.0066513Pr-135
t(11;14)down-regulatesGABPAactivatesR-1454-1.0066513Pr-135
MYCup-regulatesGABPAactivatesR-1454-1.0066513Pr-135
t(4;14)down-regulatesGABPAactivatesR-1454-1.0066513Pr-135
TACC2up-regulatesGABPAactivatesR-1454-1.0066513Pr-135
TP53up-regulatesGABPAactivatesR-1454-1.0066513Pr-135
amp1qdown-regulatesGABPAactivatesR-1454-1.0066513Pr-135
del13down-regulatesGABPAactivatesR-1454-1.0066513Pr-135
del17up-regulatesGABPAactivatesR-1454-1.0066513Pr-135
del17pup-regulatesGABPAactivatesR-1454-1.0066513Pr-135
MACF1down-regulatesELF2repressesR-9791.184849Pr-135
RNASeq_MAFA_Calldown-regulatesELF2repressesR-9791.184849Pr-135
SYNE1down-regulatesELF2repressesR-9791.184849Pr-135
TACC2down-regulatesELF2repressesR-9791.184849Pr-135
amp1qup-regulatesELF2repressesR-9791.184849Pr-135
del13up-regulatesELF2repressesR-9791.184849Pr-135
FAM46Cup-regulatesPAX6activatesR-15551.220227Pr-135
NEBup-regulatesPAX6activatesR-15551.220227Pr-135
t(11;14)down-regulatesPAX6activatesR-15551.220227Pr-135
t(11;14)_cytogeneticdown-regulatesPAX6activatesR-15551.220227Pr-135
FAT3down-regulatesETV3repressesR-2536-1.231786Pr-135
PRUNE2down-regulatesETV3repressesR-2536-1.231786Pr-135
TACC2down-regulatesETV3repressesR-2536-1.231786Pr-135
amp1qup-regulatesETV3repressesR-2536-1.231786Pr-135
del13up-regulatesETV3repressesR-2536-1.231786Pr-135
t(11;14)up-regulatesELF1repressesR-29851.2814611Pr-135
BRAFdown-regulatesGABPAactivatesR-14551.323113Pr-135
CMYA5up-regulatesGABPAactivatesR-14551.323113Pr-135
IRF4down-regulatesGABPAactivatesR-14551.323113Pr-135
MACF1up-regulatesGABPAactivatesR-14551.323113Pr-135
MUC12up-regulatesGABPAactivatesR-14551.323113Pr-135
PCDH7up-regulatesGABPAactivatesR-14551.323113Pr-135
RELNup-regulatesGABPAactivatesR-14551.323113Pr-135
t(11;14)down-regulatesGABPAactivatesR-14551.323113Pr-135
MYCup-regulatesGABPAactivatesR-14551.323113Pr-135
t(4;14)down-regulatesGABPAactivatesR-14551.323113Pr-135
RYR1up-regulatesGABPAactivatesR-14551.323113Pr-135
SYNE1up-regulatesGABPAactivatesR-14551.323113Pr-135
TACC2up-regulatesGABPAactivatesR-14551.323113Pr-135
TP53up-regulatesGABPAactivatesR-14551.323113Pr-135
TRAF3down-regulatesGABPAactivatesR-14551.323113Pr-135
XIRP2up-regulatesGABPAactivatesR-14551.323113Pr-135
ZNF462up-regulatesGABPAactivatesR-14551.323113Pr-135
amp1qdown-regulatesGABPAactivatesR-14551.323113Pr-135
del13down-regulatesGABPAactivatesR-14551.323113Pr-135
del17up-regulatesGABPAactivatesR-14551.323113Pr-135
del17pup-regulatesGABPAactivatesR-14551.323113Pr-135
t(14;16)_cytogeneticup-regulatesGABPAactivatesR-14551.323113Pr-135
t(11;14)up-regulatesSPI1repressesR-26171.3321614Pr-135
MYCdown-regulatesSPI1repressesR-26171.3321614Pr-135
SYNE1down-regulatesSPI1repressesR-26171.3321614Pr-135
t(14;16)_cytogeneticdown-regulatesSPI1repressesR-26171.3321614Pr-135
ASXL3down-regulatesGABPB1repressesR-1956-1.514386Pr-135
NEBdown-regulatesGABPB1repressesR-1956-1.514386Pr-135
PTPRDdown-regulatesGABPB1repressesR-1956-1.514386Pr-135
t(11;14)up-regulatesGABPB1repressesR-1956-1.514386Pr-135
SYNE1down-regulatesGABPB1repressesR-1956-1.514386Pr-135
TACC2down-regulatesGABPB1repressesR-1956-1.514386Pr-135
del13up-regulatesGABPB1repressesR-1956-1.514386Pr-135
amp1qup-regulatesSTAT5ArepressesR-21671.836448Pr-135
RNASeq_FGFR3_Calldown-regulatesFLI1activatesR-7911.898797Pr-135
t(4;14)down-regulatesFLI1activatesR-7911.898797Pr-135
amp1qdown-regulatesFLI1activatesR-7911.898797Pr-135
del13down-regulatesFLI1activatesR-7911.898797Pr-135
t(4;14)_cytogeneticdown-regulatesFLI1activatesR-7911.898797Pr-135
PRKD2down-regulatesFLI1activatesR-785-1.9566610Pr-135
RNASeq_FGFR3_Calldown-regulatesFLI1activatesR-785-1.9566610Pr-135
t(4;14)down-regulatesFLI1activatesR-785-1.9566610Pr-135
TRAF3down-regulatesFLI1activatesR-785-1.9566610Pr-135
amp1qdown-regulatesFLI1activatesR-785-1.9566610Pr-135
del13down-regulatesFLI1activatesR-785-1.9566610Pr-135
RNASeq_MAFA_Callup-regulatesSPIBrepressesR-672-2.1758910Pr-135
RNASeq_MAFB_Callup-regulatesSPIBrepressesR-672-2.1758910Pr-135
t(14;16)up-regulatesSPIBrepressesR-672-2.1758910Pr-135
amp1qup-regulatesSPIBrepressesR-672-2.1758910Pr-135
AHNAK2down-regulatesELK3repressesR-28472.182246Pr-135
CMYA5down-regulatesELK3repressesR-28472.182246Pr-135
MACF1down-regulatesELK3repressesR-28472.182246Pr-135
DIS3up-regulatesPRDM1repressesR-2083-2.5355910Pr-135
FGFR3up-regulatesPRDM1repressesR-2083-2.5355910Pr-135
NEBdown-regulatesPRDM1repressesR-2083-2.5355910Pr-135
RNASeq_FGFR3_Callup-regulatesPRDM1repressesR-2083-2.5355910Pr-135
t(14;16)up-regulatesPRDM1repressesR-2083-2.5355910Pr-135
t(4;14)up-regulatesPRDM1repressesR-2083-2.5355910Pr-135
amp1qup-regulatesPRDM1repressesR-2083-2.5355910Pr-135
del13up-regulatesPRDM1repressesR-2083-2.5355910Pr-135
t(4;14)_cytogeneticup-regulatesPRDM1repressesR-2083-2.5355910Pr-135
LTBdown-regulatesIRF7activatesR-1091-2.8371410Pr-135
NFKB2up-regulatesIRF7activatesR-1091-2.8371410Pr-135
NRASup-regulatesIRF7activatesR-1091-2.8371410Pr-135
RNASeq_FGFR3_Calldown-regulatesIRF7activatesR-1091-2.8371410Pr-135
t(4;14)down-regulatesIRF7activatesR-1091-2.8371410Pr-135
TRAF3down-regulatesIRF7activatesR-1091-2.8371410Pr-135
amp1qdown-regulatesIRF7activatesR-1091-2.8371410Pr-135
del13down-regulatesIRF7activatesR-1091-2.8371410Pr-135
t(4;14)_cytogeneticdown-regulatesIRF7activatesR-1091-2.8371410Pr-135
FGFR3up-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
LTBup-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
PRKD2up-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
RNASeq_FGFR3_Callup-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
t(4;14)up-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
amp1qup-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
del13up-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
t(4;14)_cytogeneticup-regulatesENSG00000176887repressesR-1890-2.9725618Pr-135
FGFR3down-regulatesSOX7activatesR-1299-3.1357423Pr-135
PRKD2down-regulatesSOX7activatesR-1299-3.1357423Pr-135
RNASeq_FGFR3_Calldown-regulatesSOX7activatesR-1299-3.1357423Pr-135
t(4;14)down-regulatesSOX7activatesR-1299-3.1357423Pr-135
RYR1up-regulatesSOX7activatesR-1299-3.1357423Pr-135
amp1qdown-regulatesSOX7activatesR-1299-3.1357423Pr-135
del13down-regulatesSOX7activatesR-1299-3.1357423Pr-135
DCHS1down-regulatesMEF2ArepressesR-1874-3.2678525Pr-135
MYO10down-regulatesMEF2ArepressesR-1874-3.2678525Pr-135
RNASeq_MAFA_Calldown-regulatesMEF2ArepressesR-1874-3.2678525Pr-135
RNASeq_MAFB_Calldown-regulatesMEF2ArepressesR-1874-3.2678525Pr-135
amp1qup-regulatesMEF2ArepressesR-1874-3.2678525Pr-135
del13up-regulatesMEF2ArepressesR-1874-3.2678525Pr-135
t(14;16)_cytogeneticdown-regulatesMEF2ArepressesR-1874-3.2678525Pr-135
BRAFdown-regulatesTEFactivatesR-2406-3.3055410Pr-135
FAT1down-regulatesTEFactivatesR-2406-3.3055410Pr-135
FGFR3down-regulatesTEFactivatesR-2406-3.3055410Pr-135
HUWE1down-regulatesTEFactivatesR-2406-3.3055410Pr-135
LTBdown-regulatesTEFactivatesR-2406-3.3055410Pr-135
MAXdown-regulatesTEFactivatesR-2406-3.3055410Pr-135
MYO10up-regulatesTEFactivatesR-2406-3.3055410Pr-135
NEBup-regulatesTEFactivatesR-2406-3.3055410Pr-135
NRASup-regulatesTEFactivatesR-2406-3.3055410Pr-135
PCDH10up-regulatesTEFactivatesR-2406-3.3055410Pr-135
PRDM1down-regulatesTEFactivatesR-2406-3.3055410Pr-135
PRKD2down-regulatesTEFactivatesR-2406-3.3055410Pr-135
RNASeq_CCND2_Callup-regulatesTEFactivatesR-2406-3.3055410Pr-135
RNASeq_FGFR3_Calldown-regulatesTEFactivatesR-2406-3.3055410Pr-135
t(14;16)down-regulatesTEFactivatesR-2406-3.3055410Pr-135
t(4;14)down-regulatesTEFactivatesR-2406-3.3055410Pr-135
RYR1up-regulatesTEFactivatesR-2406-3.3055410Pr-135
XIRP2up-regulatesTEFactivatesR-2406-3.3055410Pr-135
amp1qdown-regulatesTEFactivatesR-2406-3.3055410Pr-135
del13down-regulatesTEFactivatesR-2406-3.3055410Pr-135
t(4;14)_cytogeneticdown-regulatesTEFactivatesR-2406-3.3055410Pr-135
AHNAK2up-regulatesZBTB3repressesR-1269-3.558367Pr-135
IRF4down-regulatesZBTB3repressesR-1269-3.558367Pr-135
MUC12up-regulatesZBTB3repressesR-1269-3.558367Pr-135
t(11;14)down-regulatesZBTB3repressesR-1269-3.558367Pr-135
t(11;14)_cytogeneticdown-regulatesZBTB3repressesR-1269-3.558367Pr-135
t(14;16)_cytogeneticup-regulatesZBTB3repressesR-1269-3.558367Pr-135
t(14;16)up-regulatesZNF410repressesR-1942-3.647586Pr-135
amp1qup-regulatesZNF410repressesR-1942-3.647586Pr-135
del13up-regulatesZNF410repressesR-1942-3.647586Pr-135
RNASeq_FGFR3_Calldown-regulatesZNF740activatesR-389-3.85427Pr-135
t(14;16)down-regulatesZNF740activatesR-389-3.85427Pr-135
t(4;14)down-regulatesZNF740activatesR-389-3.85427Pr-135
amp1qdown-regulatesZNF740activatesR-389-3.85427Pr-135
del13down-regulatesZNF740activatesR-389-3.85427Pr-135
t(4;14)_cytogeneticdown-regulatesZNF740activatesR-389-3.85427Pr-135
DIS3up-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
FAT1up-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
FGFR3up-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
MAXup-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
PRKD2up-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
RNASeq_FGFR3_Callup-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
t(4;14)up-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
amp1qup-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
del13up-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
t(4;14)_cytogeneticup-regulatesENSG00000128652repressesR-2263-3.974926Pr-135
ATMup-regulatesNFATC2repressesR-1692-4.7095811Pr-135
HMCN1up-regulatesNFATC2repressesR-1692-4.7095811Pr-135
KLHL6down-regulatesNFATC2repressesR-1692-4.7095811Pr-135
RNASeq_MAFA_Callup-regulatesNFATC2repressesR-1692-4.7095811Pr-135
RNASeq_MAFB_Callup-regulatesNFATC2repressesR-1692-4.7095811Pr-135
t(14;16)up-regulatesNFATC2repressesR-1692-4.7095811Pr-135
amp1qup-regulatesNFATC2repressesR-1692-4.7095811Pr-135
del13up-regulatesNFATC2repressesR-1692-4.7095811Pr-135
t(14;16)_cytogeneticup-regulatesNFATC2repressesR-1692-4.7095811Pr-135
DNAH5down-regulatesNFATC1activatesR-2199-5.6319610Pr-135
PRKD2up-regulatesNFATC1activatesR-2199-5.6319610Pr-135
t(11;14)up-regulatesNFATC1activatesR-2199-5.6319610Pr-135
RNASeq_MAFA_Calldown-regulatesNFATC1activatesR-2199-5.6319610Pr-135
ZNF208down-regulatesNFATC1activatesR-2199-5.6319610Pr-135
t(11;14)_cytogeneticup-regulatesNFATC1activatesR-2199-5.6319610Pr-135
DIS3down-regulatesPLAG1activatesR-1523-6.0932311Pr-135
DMDdown-regulatesPLAG1activatesR-1523-6.0932311Pr-135
FAM46Cup-regulatesPLAG1activatesR-1523-6.0932311Pr-135
IRF4down-regulatesPLAG1activatesR-1523-6.0932311Pr-135
KDM3Bdown-regulatesPLAG1activatesR-1523-6.0932311Pr-135
t(11;14)down-regulatesPLAG1activatesR-1523-6.0932311Pr-135
RNASeq_MAFB_Calldown-regulatesPLAG1activatesR-1523-6.0932311Pr-135
t(14;16)down-regulatesPLAG1activatesR-1523-6.0932311Pr-135
ROBO2down-regulatesPLAG1activatesR-1523-6.0932311Pr-135
t(11;14)_cytogeneticdown-regulatesPLAG1activatesR-1523-6.0932311Pr-135
t(14;16)_cytogeneticdown-regulatesPLAG1activatesR-1523-6.0932311Pr-135
AHNAK2down-regulatesVDRactivatesR-1230-6.139617Pr-135
DSTdown-regulatesVDRactivatesR-1230-6.139617Pr-135
t(4;14)down-regulatesVDRactivatesR-1230-6.139617Pr-135
amp1qdown-regulatesVDRactivatesR-1230-6.139617Pr-135

Regulons in program Pr-135

Regulon Cox Hazard Ratio # genes # causal flows
R-311-0.073114268
R-2304-0.10382375
R-610-0.17012763
R-973-0.61578122
R-901-0.63244167
R-21030.63813963
R-341-0.75270187
R-717-0.82555586
R-2293-0.862205151
R-2067-0.873555113
R-3370.91317368
R-1454-1.006651311
R-9791.1848496
R-15551.2202274
R-2536-1.2317865
R-29851.28146111
R-14551.32311322
R-26171.33216144
R-1956-1.5143867
R-21671.8364481
R-7911.8987975
R-785-1.95666106
R-672-2.17589104
R-28472.1822463
R-2083-2.53559109
R-1091-2.83714109
R-1890-2.97256188
R-1299-3.13574237
R-1874-3.26785257
R-2406-3.305541021
R-1269-3.5583676
R-1942-3.6475863
R-389-3.854276
R-2263-3.97492610
R-1692-4.70958119
R-2199-5.63196106
R-1523-6.093231111
R-1230-6.1396174

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions