Program

Causal Mechanistic Flows with regulons in program Pr-16

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
del13down-regulatesZNF740repressesR-383-0.21666211Pr-16
AHNAK2down-regulatesIRF1activatesR-1910.28065522Pr-16
BAI3down-regulatesIRF1activatesR-1910.28065522Pr-16
t(11;14)up-regulatesIRF1activatesR-1910.28065522Pr-16
t(14;16)up-regulatesIRF1activatesR-1910.28065522Pr-16
del1pup-regulatesIRF1activatesR-1910.28065522Pr-16
t(11;14)_cytogeneticup-regulatesIRF1activatesR-1910.28065522Pr-16
AHNAK2down-regulatesHSF1activatesR-50-0.59903314Pr-16
RNASeq_CCND2_Calldown-regulatesHSF1activatesR-50-0.59903314Pr-16
RNASeq_MAFB_Calldown-regulatesHSF1activatesR-50-0.59903314Pr-16
SETD2down-regulatesHSF1activatesR-50-0.59903314Pr-16
TACC2down-regulatesHSF1activatesR-50-0.59903314Pr-16
del13up-regulatesHSF1activatesR-50-0.59903314Pr-16
t(14;16)up-regulatesMEF2DactivatesR-8720.63960912Pr-16
AHNAK2down-regulatesFOXJ2activatesR-14310.76509128Pr-16
t(11;14)up-regulatesFOXJ2activatesR-14310.76509128Pr-16
t(14;16)up-regulatesFOXJ2activatesR-14310.76509128Pr-16
TACC2down-regulatesFOXJ2activatesR-14310.76509128Pr-16
amp1qup-regulatesFOXJ2activatesR-14310.76509128Pr-16
del13up-regulatesFOXJ2activatesR-14310.76509128Pr-16
DIS3up-regulatesZFXactivatesR-19190.84973415Pr-16
t(11;14)up-regulatesZFXactivatesR-19190.84973415Pr-16
t(14;16)up-regulatesZFXactivatesR-19190.84973415Pr-16
amp1qup-regulatesZFXactivatesR-19190.84973415Pr-16
del13up-regulatesZFXactivatesR-19190.84973415Pr-16
AHNAK2down-regulatesBBXactivatesR-15320.94427815Pr-16
CYLDup-regulatesBBXactivatesR-15320.94427815Pr-16
RNASeq_CCND2_Calldown-regulatesBBXactivatesR-15320.94427815Pr-16
RNASeq_MAFA_Callup-regulatesBBXactivatesR-15320.94427815Pr-16
t(14;16)up-regulatesBBXactivatesR-15320.94427815Pr-16
ZNF208down-regulatesBBXactivatesR-15320.94427815Pr-16
del13up-regulatesBBXactivatesR-15320.94427815Pr-16
FGFR3down-regulatesPAX6repressesR-15460.9686817Pr-16
PRKD2down-regulatesPAX6repressesR-15460.9686817Pr-16
t(11;14)down-regulatesPAX6repressesR-15460.9686817Pr-16
RNASeq_FGFR3_Calldown-regulatesPAX6repressesR-15460.9686817Pr-16
t(14;16)down-regulatesPAX6repressesR-15460.9686817Pr-16
t(4;14)down-regulatesPAX6repressesR-15460.9686817Pr-16
del13down-regulatesPAX6repressesR-15460.9686817Pr-16
t(4;14)_cytogeneticdown-regulatesPAX6repressesR-15460.9686817Pr-16
AHNAK2down-regulatesFOXJ3activatesR-28841.1263727Pr-16
t(11;14)up-regulatesFOXJ3activatesR-28841.1263727Pr-16
TACC2down-regulatesFOXJ3activatesR-28841.1263727Pr-16
amp1qup-regulatesFOXJ3activatesR-28841.1263727Pr-16
del13up-regulatesFOXJ3activatesR-28841.1263727Pr-16
t(11;14)_cytogeneticup-regulatesFOXJ3activatesR-28841.1263727Pr-16
AHNAK2down-regulatesPOU2F1activatesR-841.1693427Pr-16
t(11;14)up-regulatesPOU2F1activatesR-841.1693427Pr-16
TACC2down-regulatesPOU2F1activatesR-841.1693427Pr-16
amp1qup-regulatesPOU2F1activatesR-841.1693427Pr-16
del13up-regulatesPOU2F1activatesR-841.1693427Pr-16
t(11;14)_cytogeneticup-regulatesPOU2F1activatesR-841.1693427Pr-16
AHNAK2down-regulatesRREB1activatesR-22901.2248417Pr-16
FAT3down-regulatesRREB1activatesR-22901.2248417Pr-16
TACC2down-regulatesRREB1activatesR-22901.2248417Pr-16
DIS3up-regulatesSPIBactivatesR-6661.2576618Pr-16
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6661.2576618Pr-16
t(14;16)up-regulatesSPIBactivatesR-6661.2576618Pr-16
del13up-regulatesSPIBactivatesR-6661.2576618Pr-16
del1pup-regulatesSPIBactivatesR-6661.2576618Pr-16
ASXL3down-regulatesZNF410activatesR-19351.2769410Pr-16
t(14;16)up-regulatesZNF410activatesR-19351.2769410Pr-16
amp1qup-regulatesZNF410activatesR-19351.2769410Pr-16
del13up-regulatesZNF410activatesR-19351.2769410Pr-16
AHNAK2down-regulatesFOXP1activatesR-31281.2958726Pr-16
CYLDup-regulatesFOXP1activatesR-31281.2958726Pr-16
DMDup-regulatesFOXP1activatesR-31281.2958726Pr-16
PCDH10down-regulatesFOXP1activatesR-31281.2958726Pr-16
PCDH7down-regulatesFOXP1activatesR-31281.2958726Pr-16
PRDM1up-regulatesFOXP1activatesR-31281.2958726Pr-16
t(11;14)up-regulatesFOXP1activatesR-31281.2958726Pr-16
RNASeq_CCND2_Calldown-regulatesFOXP1activatesR-31281.2958726Pr-16
RNASeq_MAFA_Callup-regulatesFOXP1activatesR-31281.2958726Pr-16
t(14;16)up-regulatesFOXP1activatesR-31281.2958726Pr-16
TACC2down-regulatesFOXP1activatesR-31281.2958726Pr-16
amp1qup-regulatesFOXP1activatesR-31281.2958726Pr-16
del13up-regulatesFOXP1activatesR-31281.2958726Pr-16
del1pup-regulatesFOXP1activatesR-31281.2958726Pr-16
t(11;14)_cytogeneticup-regulatesFOXP1activatesR-31281.2958726Pr-16
AHNAK2down-regulatesMEF2AactivatesR-18711.3538428Pr-16
RNASeq_CCND2_Calldown-regulatesMEF2AactivatesR-18711.3538428Pr-16
TACC2down-regulatesMEF2AactivatesR-18711.3538428Pr-16
amp1qup-regulatesMEF2AactivatesR-18711.3538428Pr-16
del13up-regulatesMEF2AactivatesR-18711.3538428Pr-16
AHNAK2up-regulatesE2F2repressesR-29491.404086Pr-16
FAT3up-regulatesE2F2repressesR-29491.404086Pr-16
MAXup-regulatesE2F2repressesR-29491.404086Pr-16
PTPRDup-regulatesE2F2repressesR-29491.404086Pr-16
SVILup-regulatesE2F2repressesR-29491.404086Pr-16
TACC2up-regulatesE2F2repressesR-29491.404086Pr-16
MAXdown-regulatesIRX3activatesR-22271.4778112Pr-16
del1pup-regulatesIRX3activatesR-22271.4778112Pr-16
AHNAK2down-regulatesRARAactivatesR-1561.7147115Pr-16
DNAH5down-regulatesRARAactivatesR-1561.7147115Pr-16
IRF4up-regulatesRARAactivatesR-1561.7147115Pr-16
PCDH10down-regulatesRARAactivatesR-1561.7147115Pr-16
PCDH7down-regulatesRARAactivatesR-1561.7147115Pr-16
t(11;14)up-regulatesRARAactivatesR-1561.7147115Pr-16
del13up-regulatesRARAactivatesR-1561.7147115Pr-16
t(11;14)_cytogeneticup-regulatesRARAactivatesR-1561.7147115Pr-16
t(11;14)up-regulatesRELactivatesR-12792.173666Pr-16
RNASeq_FGFR3_Callup-regulatesRELactivatesR-12792.173666Pr-16
TACC2down-regulatesRELactivatesR-12792.173666Pr-16
del1pup-regulatesRELactivatesR-12792.173666Pr-16
t(11;14)_cytogeneticup-regulatesRELactivatesR-12792.173666Pr-16
t(4;14)_cytogeneticup-regulatesRELactivatesR-12792.173666Pr-16
PRDM1up-regulatesYY1activatesR-25222.2783619Pr-16
RNASeq_CCND2_Calldown-regulatesYY1activatesR-25222.2783619Pr-16
RNASeq_MAFA_Callup-regulatesYY1activatesR-25222.2783619Pr-16
del13up-regulatesYY1activatesR-25222.2783619Pr-16

Regulons in program Pr-16

Regulon Cox Hazard Ratio # genes # causal flows
R-383-0.216662111
R-1910.280655226
R-50-0.599033146
R-8720.639609121
R-14310.765091286
R-19190.849734155
R-15320.944278157
R-15460.96868178
R-28841.12637276
R-841.16934276
R-22901.22484173
R-6661.25766185
R-19351.27694104
R-31281.295872615
R-18711.35384285
R-29491.4040866
R-22271.47781122
R-1561.71471158
R-12792.1736666
R-25222.27836194

Genes in program Pr-16

EnsEMBL IdEntrez IdPreferred
ENSG00000177463 7182NR2C2
ENSG00000178104 653513LOC653513
ENSG00000182919 28970C11orf54
ENSG00000183579 84133ZNRF3
ENSG00000185115 56160NSMCE3
ENSG00000186105 100130733LRRC70
ENSG00000187325 51616TAF9B
ENSG00000187676 145173B3GLCT
ENSG00000196456 285971ZNF775
ENSG00000196850 160760PPTC7
ENSG00000197323 51592TRIM33
ENSG00000197555 26037SIPA1L1
ENSG00000197714 10794ZNF460
ENSG00000197863 388536ZNF790
ENSG00000198315 7745ZKSCAN8
ENSG00000198707 80184CEP290
ENSG00000198894 85457CIPC
ENSG00000213203 170575GIMAP1
ENSG00000244482 79168LILRA6
ENSG00000254505 29082CHMP4A

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions