Program

Causal Mechanistic Flows with regulons in program Pr-129

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
RNASeq_MAFA_Callup-regulatesNFIArepressesR-3560.2867017Pr-129
DIS3up-regulatesZFXactivatesR-1920-0.31960512Pr-129
FAM46Cdown-regulatesZFXactivatesR-1920-0.31960512Pr-129
FGFR3up-regulatesZFXactivatesR-1920-0.31960512Pr-129
LTBup-regulatesZFXactivatesR-1920-0.31960512Pr-129
t(11;14)up-regulatesZFXactivatesR-1920-0.31960512Pr-129
RNASeq_FGFR3_Callup-regulatesZFXactivatesR-1920-0.31960512Pr-129
t(14;16)up-regulatesZFXactivatesR-1920-0.31960512Pr-129
t(4;14)up-regulatesZFXactivatesR-1920-0.31960512Pr-129
t(4;14)_cytogeneticup-regulatesZFXactivatesR-1920-0.31960512Pr-129
DIS3up-regulatesKLF4activatesR-2758-0.4262927Pr-129
FGFR3up-regulatesKLF4activatesR-2758-0.4262927Pr-129
MAXup-regulatesKLF4activatesR-2758-0.4262927Pr-129
MUC16down-regulatesKLF4activatesR-2758-0.4262927Pr-129
NRASdown-regulatesKLF4activatesR-2758-0.4262927Pr-129
PRKD2up-regulatesKLF4activatesR-2758-0.4262927Pr-129
RNASeq_FGFR3_Callup-regulatesKLF4activatesR-2758-0.4262927Pr-129
MYCdown-regulatesKLF4activatesR-2758-0.4262927Pr-129
t(4;14)up-regulatesKLF4activatesR-2758-0.4262927Pr-129
ROBO1down-regulatesKLF4activatesR-2758-0.4262927Pr-129
t(4;14)_cytogeneticup-regulatesKLF4activatesR-2758-0.4262927Pr-129
t(11;14)down-regulatesRORArepressesR-22740.5082338Pr-129
DCHS1up-regulatesMAZactivatesR-5070.5376299Pr-129
DIS3up-regulatesMAZactivatesR-5070.5376299Pr-129
FAM46Cdown-regulatesMAZactivatesR-5070.5376299Pr-129
FGFR3up-regulatesMAZactivatesR-5070.5376299Pr-129
NRASdown-regulatesMAZactivatesR-5070.5376299Pr-129
PRKD2up-regulatesMAZactivatesR-5070.5376299Pr-129
RELNup-regulatesMAZactivatesR-5070.5376299Pr-129
RNASeq_FGFR3_Callup-regulatesMAZactivatesR-5070.5376299Pr-129
t(4;14)up-regulatesMAZactivatesR-5070.5376299Pr-129
SETD2up-regulatesMAZactivatesR-5070.5376299Pr-129
TRAF3up-regulatesMAZactivatesR-5070.5376299Pr-129
TRIOup-regulatesMAZactivatesR-5070.5376299Pr-129
t(14;16)_cytogeneticup-regulatesMAZactivatesR-5070.5376299Pr-129
t(4;14)_cytogeneticup-regulatesMAZactivatesR-5070.5376299Pr-129
DCHS1down-regulatesMEF2ArepressesR-18860.55295913Pr-129
DIS3down-regulatesMEF2ArepressesR-18860.55295913Pr-129
FAM46Cup-regulatesMEF2ArepressesR-18860.55295913Pr-129
MAXdown-regulatesMEF2ArepressesR-18860.55295913Pr-129
NRASup-regulatesMEF2ArepressesR-18860.55295913Pr-129
PTPRDdown-regulatesMEF2ArepressesR-18860.55295913Pr-129
RNASeq_CCND2_Calldown-regulatesMEF2ArepressesR-18860.55295913Pr-129
RNASeq_FGFR3_Calldown-regulatesMEF2ArepressesR-18860.55295913Pr-129
t(4;14)down-regulatesMEF2ArepressesR-18860.55295913Pr-129
SETD2down-regulatesMEF2ArepressesR-18860.55295913Pr-129
t(14;16)_cytogeneticdown-regulatesMEF2ArepressesR-18860.55295913Pr-129
CYLDdown-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
FGFR3up-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
IRF4up-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
KRASup-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
LTBup-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
MAXup-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
PRKD2up-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
t(11;14)up-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
t(4;14)up-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
ROBO1down-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
SETD2up-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
TTNdown-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
t(11;14)_cytogeneticup-regulatesCEBPBactivatesR-1777-0.8386666Pr-129
DIS3up-regulatesNFYAactivatesR-14790.894777Pr-129
FGFR3up-regulatesNFYAactivatesR-14790.894777Pr-129
LTBup-regulatesNFYAactivatesR-14790.894777Pr-129
NRASdown-regulatesNFYAactivatesR-14790.894777Pr-129
t(11;14)up-regulatesNFYAactivatesR-14790.894777Pr-129
RNASeq_FGFR3_Callup-regulatesNFYAactivatesR-14790.894777Pr-129
t(4;14)up-regulatesNFYAactivatesR-14790.894777Pr-129
TRIOup-regulatesNFYAactivatesR-14790.894777Pr-129
t(4;14)_cytogeneticup-regulatesNFYAactivatesR-14790.894777Pr-129
DIS3up-regulatesJUNactivatesR-11801.0626710Pr-129
t(11;14)up-regulatesJUNactivatesR-11801.0626710Pr-129
ROBO1down-regulatesJUNactivatesR-11801.0626710Pr-129
t(11;14)_cytogeneticup-regulatesJUNactivatesR-11801.0626710Pr-129
FAT3up-regulatesZNF143activatesR-2321-1.329917Pr-129
NRASup-regulatesCEBPZrepressesR-7561.3616Pr-129
DIS3up-regulatesJUNactivatesR-1179-1.5089611Pr-129
t(11;14)up-regulatesJUNactivatesR-1179-1.5089611Pr-129
ROBO1down-regulatesJUNactivatesR-1179-1.5089611Pr-129
TP53down-regulatesJUNactivatesR-1179-1.5089611Pr-129
t(11;14)_cytogeneticup-regulatesJUNactivatesR-1179-1.5089611Pr-129

Regulons in program Pr-129

Regulon Cox Hazard Ratio # genes # causal flows
R-3560.28670171
R-1920-0.319605129
R-2758-0.426292711
R-22740.50823381
R-5070.537629914
R-18860.5529591311
R-1777-0.838666614
R-14790.8947779
R-11801.06267104
R-2321-1.3299171
R-7561.36161
R-1179-1.50896115

Genes in program Pr-129

EnsEMBL IdEntrez IdPreferred
ENSG00000178149 55152DALRD3
ENSG00000178585 56998CTNNBIP1
ENSG00000180185 81889FAHD1
ENSG00000181472 57621ZBTB2
ENSG00000181856 6517SLC2A4
ENSG00000182179 7318UBA7
ENSG00000185909 200942KLHDC8B
ENSG00000186666 144233BCDIN3D
ENSG00000189057 374393FAM111B
ENSG00000198162 10905MAN1A2
ENSG00000198331 219844HYLS1
ENSG00000203485 64423INF2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions