Program

Causal Mechanistic Flows with regulons in program Pr-136

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
del13down-regulatesZBTB3activatesR-1265-0.086053312Pr-136
del17up-regulatesZBTB3activatesR-1265-0.086053312Pr-136
t(14;16)_cytogeneticup-regulatesZBTB3activatesR-1265-0.086053312Pr-136
del1pup-regulatesSTAT5ArepressesR-21640.20054211Pr-136
NRASup-regulatesIRF1repressesR-193-0.54986917Pr-136
t(11;14)down-regulatesSTAT1activatesR-3073-0.6096236Pr-136
RNASeq_FGFR3_Callup-regulatesSTAT1activatesR-3073-0.6096236Pr-136
t(4;14)up-regulatesSTAT1activatesR-3073-0.6096236Pr-136
del17up-regulatesSTAT1activatesR-3073-0.6096236Pr-136
t(11;14)_cytogeneticdown-regulatesSTAT1activatesR-3073-0.6096236Pr-136
amp1qup-regulatesELK1repressesR-638-0.77269516Pr-136
del1pup-regulatesELK1repressesR-638-0.77269516Pr-136
ROBO2up-regulatesPARP1activatesR-2640-0.8461268Pr-136
SETD2up-regulatesPARP1activatesR-2640-0.8461268Pr-136
AHNAK2down-regulatesETV3repressesR-25310.91983514Pr-136
FAT3down-regulatesETV3repressesR-25310.91983514Pr-136
RNASeq_MAFA_Calldown-regulatesETV3repressesR-25310.91983514Pr-136
SYNE1down-regulatesETV3repressesR-25310.91983514Pr-136
TACC2down-regulatesETV3repressesR-25310.91983514Pr-136
AHNAK2down-regulatesZEB1repressesR-22380.92988523Pr-136
PCDH10down-regulatesZEB1repressesR-22380.92988523Pr-136
TACC2down-regulatesZEB1repressesR-22380.92988523Pr-136
AHNAK2down-regulatesERFrepressesR-3310.96915112Pr-136
DCHS1down-regulatesERFrepressesR-3310.96915112Pr-136
FAT3down-regulatesERFrepressesR-3310.96915112Pr-136
MACF1down-regulatesERFrepressesR-3310.96915112Pr-136
MAGI1down-regulatesERFrepressesR-3310.96915112Pr-136
MAXdown-regulatesERFrepressesR-3310.96915112Pr-136
NRASup-regulatesERFrepressesR-3310.96915112Pr-136
PTPRDdown-regulatesERFrepressesR-3310.96915112Pr-136
RNASeq_FGFR3_Calldown-regulatesERFrepressesR-3310.96915112Pr-136
RNASeq_MAFA_Calldown-regulatesERFrepressesR-3310.96915112Pr-136
t(4;14)down-regulatesERFrepressesR-3310.96915112Pr-136
SETD2down-regulatesERFrepressesR-3310.96915112Pr-136
SYNE1down-regulatesERFrepressesR-3310.96915112Pr-136
TACC2down-regulatesERFrepressesR-3310.96915112Pr-136
t(14;16)_cytogeneticdown-regulatesERFrepressesR-3310.96915112Pr-136
t(4;14)_cytogeneticdown-regulatesERFrepressesR-3310.96915112Pr-136
FAT3down-regulatesETS1repressesR-00.9853531Pr-136
MAXdown-regulatesETS1repressesR-00.9853531Pr-136
RNASeq_CCND2_Calldown-regulatesETS1repressesR-00.9853531Pr-136
t(4;14)down-regulatesETS1repressesR-00.9853531Pr-136
t(11;14)up-regulatesETV5repressesR-3391.00213Pr-136
RNASeq_MAFA_Calldown-regulatesETV5repressesR-3391.00213Pr-136
SDK1down-regulatesETV5repressesR-3391.00213Pr-136
SYNE1down-regulatesETV5repressesR-3391.00213Pr-136
ABCA13down-regulatesELK3repressesR-28451.0822914Pr-136
AHNAK2down-regulatesELK3repressesR-28451.0822914Pr-136
CMYA5down-regulatesELK3repressesR-28451.0822914Pr-136
DNAH5down-regulatesELK3repressesR-28451.0822914Pr-136
MACF1down-regulatesELK3repressesR-28451.0822914Pr-136
t(11;14)up-regulatesELK3repressesR-28451.0822914Pr-136
RELNdown-regulatesETS2repressesR-19021.1434811Pr-136
t(11;14)up-regulatesETS2repressesR-19021.1434811Pr-136
t(14;16)_cytogeneticdown-regulatesETS2repressesR-19021.1434811Pr-136
t(11;14)down-regulatesKLF16repressesR-2701-1.197877Pr-136
CMYA5up-regulatesGABPAactivatesR-14521.480927Pr-136
MACF1up-regulatesGABPAactivatesR-14521.480927Pr-136
PCDH7up-regulatesGABPAactivatesR-14521.480927Pr-136
RELNup-regulatesGABPAactivatesR-14521.480927Pr-136
t(11;14)down-regulatesGABPAactivatesR-14521.480927Pr-136
SYNE1up-regulatesGABPAactivatesR-14521.480927Pr-136
TACC2up-regulatesGABPAactivatesR-14521.480927Pr-136
TP53up-regulatesGABPAactivatesR-14521.480927Pr-136
del17up-regulatesGABPAactivatesR-14521.480927Pr-136
t(14;16)_cytogeneticup-regulatesGABPAactivatesR-14521.480927Pr-136
amp1qup-regulatesETV6repressesR-702-1.5181913Pr-136
del13up-regulatesETV6repressesR-702-1.5181913Pr-136
del1pup-regulatesETV6repressesR-702-1.5181913Pr-136
AHNAK2down-regulatesETV6repressesR-6951.642729Pr-136
PCDH10down-regulatesETV6repressesR-6951.642729Pr-136
ABCA13down-regulatesRFX1repressesR-25661.6677614Pr-136
AHNAK2down-regulatesRFX1repressesR-25661.6677614Pr-136
CMYA5down-regulatesRFX1repressesR-25661.6677614Pr-136
DNAH5down-regulatesRFX1repressesR-25661.6677614Pr-136
MACF1down-regulatesRFX1repressesR-25661.6677614Pr-136
t(11;14)up-regulatesRFX1repressesR-25661.6677614Pr-136
SYNE1down-regulatesRFX1repressesR-25661.6677614Pr-136
del13up-regulatesRFX1repressesR-25661.6677614Pr-136
AHNAK2down-regulatesFOXJ2repressesR-14211.7024643Pr-136
MAGI1down-regulatesFOXJ2repressesR-14211.7024643Pr-136
t(11;14)up-regulatesFOXJ2repressesR-14211.7024643Pr-136
TACC2down-regulatesFOXJ2repressesR-14211.7024643Pr-136
DCHS1down-regulatesMAFKrepressesR-2803-1.7293615Pr-136
DNAH5down-regulatesMAFKrepressesR-2803-1.7293615Pr-136
FAT3down-regulatesMAFKrepressesR-2803-1.7293615Pr-136
AHNAK2down-regulatesHBP1repressesR-18271.7397824Pr-136
DCHS1down-regulatesHBP1repressesR-18271.7397824Pr-136
DNAH5down-regulatesHBP1repressesR-18271.7397824Pr-136
FAT3down-regulatesHBP1repressesR-18271.7397824Pr-136
MACF1down-regulatesHBP1repressesR-18271.7397824Pr-136
MAGI1down-regulatesHBP1repressesR-18271.7397824Pr-136
MYO10down-regulatesHBP1repressesR-18271.7397824Pr-136
NEBdown-regulatesHBP1repressesR-18271.7397824Pr-136
PCDH10down-regulatesHBP1repressesR-18271.7397824Pr-136
PTPRDdown-regulatesHBP1repressesR-18271.7397824Pr-136
t(11;14)up-regulatesHBP1repressesR-18271.7397824Pr-136
SYNE1down-regulatesHBP1repressesR-18271.7397824Pr-136
TACC2down-regulatesHBP1repressesR-18271.7397824Pr-136
FAM46Cdown-regulatesATF5activatesR-2404-1.755411Pr-136
NRASdown-regulatesATF5activatesR-2404-1.755411Pr-136
RELNup-regulatesATF5activatesR-2404-1.755411Pr-136
t(11;14)up-regulatesATF5activatesR-2404-1.755411Pr-136
RNASeq_FGFR3_Callup-regulatesATF5activatesR-2404-1.755411Pr-136
t(4;14)up-regulatesATF5activatesR-2404-1.755411Pr-136
t(11;14)_cytogeneticup-regulatesATF5activatesR-2404-1.755411Pr-136
AHNAK2down-regulatesNRF1repressesR-27051.9136912Pr-136
DNAH5down-regulatesNRF1repressesR-27051.9136912Pr-136
NEBdown-regulatesNRF1repressesR-27051.9136912Pr-136
PTPRDdown-regulatesNRF1repressesR-27051.9136912Pr-136
t(11;14)up-regulatesNRF1repressesR-27051.9136912Pr-136
SDK1down-regulatesNRF1repressesR-27051.9136912Pr-136
SYNE1down-regulatesNRF1repressesR-27051.9136912Pr-136
TP53down-regulatesNRF1repressesR-27051.9136912Pr-136
del17down-regulatesNRF1repressesR-27051.9136912Pr-136
t(11;14)_cytogeneticup-regulatesNRF1repressesR-27051.9136912Pr-136
amp1qdown-regulatesGABPAactivatesR-1453-1.9799118Pr-136
del13down-regulatesGABPAactivatesR-1453-1.9799118Pr-136
AHNAK2down-regulatesRORArepressesR-22662.0591619Pr-136
MAGI1down-regulatesRORArepressesR-22662.0591619Pr-136
ABCA13down-regulatesPOU2F1repressesR-872.0788822Pr-136
CMYA5down-regulatesPOU2F1repressesR-872.0788822Pr-136
DNAH5down-regulatesPOU2F1repressesR-872.0788822Pr-136
FAT3down-regulatesPOU2F1repressesR-872.0788822Pr-136
KALRNdown-regulatesPOU2F1repressesR-872.0788822Pr-136
amp1qup-regulatesPOU2F1repressesR-872.0788822Pr-136
del13up-regulatesPOU2F1repressesR-872.0788822Pr-136
FAM46Cup-regulatesHMGA1repressesR-8342.308436Pr-136
IRF4down-regulatesHMGA1repressesR-8342.308436Pr-136
MAXdown-regulatesHMGA1repressesR-8342.308436Pr-136
NRASup-regulatesHMGA1repressesR-8342.308436Pr-136
PRKD2down-regulatesHMGA1repressesR-8342.308436Pr-136
t(11;14)down-regulatesHMGA1repressesR-8342.308436Pr-136
RNASeq_CCND3_Calldown-regulatesHMGA1repressesR-8342.308436Pr-136
RNASeq_FGFR3_Calldown-regulatesHMGA1repressesR-8342.308436Pr-136
RNASeq_MAFA_Calldown-regulatesHMGA1repressesR-8342.308436Pr-136
RNASeq_MAFB_Calldown-regulatesHMGA1repressesR-8342.308436Pr-136
t(14;16)down-regulatesHMGA1repressesR-8342.308436Pr-136
t(4;14)down-regulatesHMGA1repressesR-8342.308436Pr-136
t(11;14)_cytogeneticdown-regulatesHMGA1repressesR-8342.308436Pr-136
t(4;14)_cytogeneticdown-regulatesHMGA1repressesR-8342.308436Pr-136
t(14;16)_cytogeneticdown-regulatesCREB5repressesR-7792.394396Pr-136
DIS3up-regulatesNFYAactivatesR-14712.4337814Pr-136
NRASdown-regulatesNFYAactivatesR-14712.4337814Pr-136
t(11;14)up-regulatesNFYAactivatesR-14712.4337814Pr-136
RNASeq_FGFR3_Callup-regulatesNFYAactivatesR-14712.4337814Pr-136
t(4;14)up-regulatesNFYAactivatesR-14712.4337814Pr-136
t(4;14)_cytogeneticup-regulatesNFYAactivatesR-14712.4337814Pr-136
AHNAK2down-regulatesERFrepressesR-3352.468066Pr-136
FAT3down-regulatesERFrepressesR-3352.468066Pr-136
MACF1down-regulatesERFrepressesR-3352.468066Pr-136
MAXdown-regulatesERFrepressesR-3352.468066Pr-136
NRASup-regulatesERFrepressesR-3352.468066Pr-136
RNASeq_MAFA_Calldown-regulatesERFrepressesR-3352.468066Pr-136
t(4;14)down-regulatesERFrepressesR-3352.468066Pr-136
SETD2down-regulatesERFrepressesR-3352.468066Pr-136
t(14;16)_cytogeneticdown-regulatesERFrepressesR-3352.468066Pr-136
FAM46Cup-regulatesENSG00000168269repressesR-15712.517366Pr-136
IRF4down-regulatesENSG00000168269repressesR-15712.517366Pr-136
PRKD2down-regulatesENSG00000168269repressesR-15712.517366Pr-136
PTPRDdown-regulatesENSG00000168269repressesR-15712.517366Pr-136
t(11;14)down-regulatesENSG00000168269repressesR-15712.517366Pr-136
RNASeq_MAFB_Calldown-regulatesENSG00000168269repressesR-15712.517366Pr-136
TACC2down-regulatesENSG00000168269repressesR-15712.517366Pr-136
TTNdown-regulatesENSG00000168269repressesR-15712.517366Pr-136
ZFHX3down-regulatesENSG00000168269repressesR-15712.517366Pr-136
t(11;14)_cytogeneticdown-regulatesENSG00000168269repressesR-15712.517366Pr-136
FAT3down-regulatesELF2repressesR-970-2.6119614Pr-136
KALRNdown-regulatesELF2repressesR-970-2.6119614Pr-136
amp1qup-regulatesELF2repressesR-970-2.6119614Pr-136
del13up-regulatesELF2repressesR-970-2.6119614Pr-136
NRASup-regulatesRFX7repressesR-2751-2.757426Pr-136
t(11;14)down-regulatesRFX7repressesR-2751-2.757426Pr-136
ROBO1up-regulatesRFX7repressesR-2751-2.757426Pr-136
t(11;14)_cytogeneticdown-regulatesRFX7repressesR-2751-2.757426Pr-136
AHNAK2up-regulatesE2F8activatesR-16294.143636Pr-136
FAT3up-regulatesE2F8activatesR-16294.143636Pr-136
MACF1up-regulatesE2F8activatesR-16294.143636Pr-136
MAXup-regulatesE2F8activatesR-16294.143636Pr-136
t(11;14)up-regulatesE2F8activatesR-16294.143636Pr-136
t(14;16)up-regulatesE2F8activatesR-16294.143636Pr-136
TP53up-regulatesE2F8activatesR-16294.143636Pr-136
ZNF462up-regulatesE2F8activatesR-16294.143636Pr-136
t(14;16)_cytogeneticup-regulatesE2F8activatesR-16294.143636Pr-136

Regulons in program Pr-136

Regulon Cox Hazard Ratio # genes # causal flows
R-1265-0.0860533123
R-21640.200542111
R-193-0.549869171
R-3073-0.60962365
R-638-0.772695162
R-2640-0.84612682
R-25310.919835145
R-22380.929885233
R-3310.9691511216
R-00.98535314
R-3391.002134
R-28451.08229146
R-19021.14348113
R-2701-1.1978771
R-14521.48092710
R-702-1.51819133
R-6951.6427292
R-25661.66776148
R-14211.70246434
R-2803-1.72936153
R-18271.739782413
R-2404-1.7554117
R-27051.913691210
R-1453-1.97991182
R-22662.05916192
R-872.07888227
R-8342.30843614
R-7792.3943961
R-14712.43378146
R-3352.4680669
R-15712.51736610
R-970-2.61196144
R-2751-2.7574264
R-16294.1436369

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions