Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

NFYA - nuclear transcription factor Y subunit alpha

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4800 ENSG00000001167 NFYA P23511

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: NFYA

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
t(11;14)NFYAactivatesR-1472-0.798881Pr-59
DIS3NFYAactivatesR-14790.89477Pr-129
FGFR3NFYAactivatesR-14790.89477Pr-129
LTBNFYAactivatesR-14790.89477Pr-129
NRASNFYAactivatesR-14790.89477Pr-129
t(11;14)NFYAactivatesR-14790.89477Pr-129
RNASeq_FGFR3_CallNFYAactivatesR-14790.89477Pr-129
t(4;14)NFYAactivatesR-14790.89477Pr-129
TRIONFYAactivatesR-14790.89477Pr-129
t(4;14)_cytogeneticNFYAactivatesR-14790.89477Pr-129
RNASeq_FGFR3_CallNFYArepressesR-1476-1.47325Pr-9
t(4;14)NFYArepressesR-1476-1.47325Pr-9
t(4;14)_cytogeneticNFYArepressesR-1476-1.47325Pr-9
t(11;14)NFYArepressesR-1470-1.56312Pr-15
RNASeq_FGFR3_CallNFYArepressesR-1470-1.56312Pr-15
DIS3NFYAactivatesR-14782.17892Pr-109
FGFR3NFYAactivatesR-14782.17892Pr-109
t(11;14)NFYAactivatesR-14782.17892Pr-109
RNASeq_FGFR3_CallNFYAactivatesR-14782.17892Pr-109
t(4;14)NFYAactivatesR-14782.17892Pr-109
t(4;14)_cytogeneticNFYAactivatesR-14782.17892Pr-109
t(4;14)NFYAactivatesR-1474-2.29686Pr-104
DIS3NFYArepressesR-1468-2.37586Pr-4
NRASNFYArepressesR-1468-2.37586Pr-4
t(11;14)NFYArepressesR-1468-2.37586Pr-4
RNASeq_FGFR3_CallNFYArepressesR-1468-2.37586Pr-4
t(4;14)NFYArepressesR-1468-2.37586Pr-4
t(4;14)_cytogeneticNFYArepressesR-1468-2.37586Pr-4
DIS3NFYAactivatesR-14712.43378Pr-136
NRASNFYAactivatesR-14712.43378Pr-136
t(11;14)NFYAactivatesR-14712.43378Pr-136
RNASeq_FGFR3_CallNFYAactivatesR-14712.43378Pr-136
t(4;14)NFYAactivatesR-14712.43378Pr-136
t(4;14)_cytogeneticNFYAactivatesR-14712.43378Pr-136
DIS3NFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FGFR3NFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

LTBNFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

NRASNFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_FGFR3_CallNFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)NFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

TRIONFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)_cytogeneticNFYAactivatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

DIS3NFYAactivatesR-14694.55792Pr-70
t(11;14)NFYAactivatesR-14694.55792Pr-70
RNASeq_FGFR3_CallNFYAactivatesR-14694.55792Pr-70
t(4;14)NFYAactivatesR-14694.55792Pr-70
DIS3NFYAactivatesR-14754.71043Pr-128
FGFR3NFYAactivatesR-14754.71043Pr-128
NRASNFYAactivatesR-14754.71043Pr-128
t(11;14)NFYAactivatesR-14754.71043Pr-128
RNASeq_FGFR3_CallNFYAactivatesR-14754.71043Pr-128
t(4;14)NFYAactivatesR-14754.71043Pr-128
TRIONFYAactivatesR-14754.71043Pr-128
t(4;14)_cytogeneticNFYAactivatesR-14754.71043Pr-128

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.