Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation ZNF462

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
ETV5down-regulatesR-3420.139146Pr-117
RARBup-regulatesR-1107-0.777096Pr-9
SATB1down-regulatesR-10801.00536Pr-130
CREB3L2down-regulatesR-521-1.29128Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

GABPAup-regulatesR-14551.3231Pr-135
RREB1down-regulatesR-2305-1.52832Pr-0
KLF7down-regulatesR-281-1.54497Pr-12
RREB1down-regulatesR-2291-1.6207Pr-12
RREB1down-regulatesR-2303-1.65549Pr-113
VBP1up-regulatesR-21021.67538Pr-73
SRFdown-regulatesR-17862.43898Pr-117
E2F2up-regulatesR-2948-3.01545Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SP1up-regulatesR-27153.33045Pr-78

Genes (2)

STIMATE, DDOST

Regulons (6)

R-1941, R-2744, R-656, R-2715, R-2072, R-1512

STAT3down-regulatesR-307-3.61941Pr-11
KLF7down-regulatesR-2853.90122Pr-74
ETV5down-regulatesR-3433.98861Pr-74
SRFdown-regulatesR-17814.13916Pr-70
E2F8up-regulatesR-16294.14363Pr-136
KLF7down-regulatesR-280-4.33884Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SP1up-regulatesR-2735-4.34716Pr-42
RREB1down-regulatesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SP1up-regulatesR-2724-4.65176Pr-110
E2F1up-regulatesR-21745.04725Pr-63
SRFdown-regulatesR-1787-5.29074Pr-104
RARBup-regulatesR-1110-5.34822Pr-110
SP1up-regulatesR-2720-6.02354Pr-104
SP1up-regulatesR-27196.73271Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

KLF7down-regulatesR-2837.07253Pr-68
PARP1up-regulatesR-26368.12838Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions