Regulator – Multiple Myeloma Network Portal

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ETS1 - ETS proto-oncogene 1, transcription factor

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
2113	ENSG00000134954	ETS1	P14921

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ETS1

Mutation	Regulator	Role	Regulon	Cox Hazard Ratio	Transcriptional Program
ATM	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
CACNA1H	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
NRAS	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
RNASeq_MAFA_Call	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
RNASeq_MAFB_Call	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(14;16)	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
SYNE2	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
TRAF3	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
ZNF208	ETS1	activates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
ACTG1	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
CACNA1H	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
CYLD	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
DSCAML1	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
FGFR3	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
KIAA1244	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
KRAS	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
MAX	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
NFKB2	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
PRKD2	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
RNASeq_CCND2_Call	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
RNASeq_FGFR3_Call	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
RNASeq_MAFA_Call	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
RNASeq_MAFB_Call	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
t(14;16)	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
t(4;14)	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
t(4;14)_cytogenetic	ETS1	represses	R-12	-0.427939	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
CYLD	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
FAT2	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
FGFR3	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
MAX	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
NRAS	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
PRKD2	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
RNASeq_FGFR3_Call	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
RNASeq_MAFA_Call	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
RNASeq_MAFB_Call	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
t(14;16)	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
t(4;14)	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
ZNF208	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
t(4;14)_cytogenetic	ETS1	activates	R-7	-0.82093	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
FAT3	ETS1	activates	R-4	-0.886127	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
MAX	ETS1	activates	R-4	-0.886127	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
RNASeq_CCND2_Call	ETS1	activates	R-4	-0.886127	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
RNASeq_FGFR3_Call	ETS1	activates	R-4	-0.886127	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
t(4;14)	ETS1	activates	R-4	-0.886127	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
t(4;14)_cytogenetic	ETS1	activates	R-4	-0.886127	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
MAX	ETS1	activates	R-14	-0.914198	Pr-35 Genes (10) ZBTB7A, TMEM107, BHLHA15, GLTPD2, ZNF395, MAFB, SMIM13, AKAP2, FOX3A Regulons (20) R-2747, R-3059, R-336, R-2624, R-1948, R-14, R-277, R-2826, R-1570, R-1094, R-1244, R-2621, R-1232, R-1506, R-3019, R-493, R-1945, R-2691, R-1963, R-2244
RNASeq_CCND2_Call	ETS1	activates	R-14	-0.914198	Pr-35 Genes (10) ZBTB7A, TMEM107, BHLHA15, GLTPD2, ZNF395, MAFB, SMIM13, AKAP2, FOX3A Regulons (20) R-2747, R-3059, R-336, R-2624, R-1948, R-14, R-277, R-2826, R-1570, R-1094, R-1244, R-2621, R-1232, R-1506, R-3019, R-493, R-1945, R-2691, R-1963, R-2244
FAT3	ETS1	represses	R-0	0.98535	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
MAX	ETS1	represses	R-0	0.98535	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
RNASeq_CCND2_Call	ETS1	represses	R-0	0.98535	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
t(4;14)	ETS1	represses	R-0	0.98535	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
ACTG1	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
ATM	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
DMD	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
NRAS	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
RNASeq_CCND2_Call	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
RNASeq_MAFA_Call	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
RNASeq_MAFB_Call	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
t(14;16)	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
TRAF3	ETS1	activates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
CACNA1H	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
CYLD	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
DSCAML1	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
FGFR3	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
KIAA1244	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
KRAS	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
NRAS	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
PRKD2	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
RNASeq_FGFR3_Call	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
RNASeq_MAFA_Call	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
RNASeq_MAFB_Call	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
t(14;16)	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
t(4;14)	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
SYNE2	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
t(4;14)_cytogenetic	ETS1	represses	R-10	1.31637	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
CYLD	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
MAX	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
NRAS	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
RNASeq_CCND2_Call	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
RNASeq_MAFA_Call	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
RNASeq_MAFB_Call	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
t(14;16)	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
SYNE2	ETS1	activates	R-8	1.3888	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
FAT2	ETS1	activates	R-3	-1.52284	Pr-90 Genes (13) FOSL1, SMIM19, ZNRF2, BRF1, INSIG1, CHP1, S100A4, HDAC2, ZNF347, FAM229B, ZNF512, FAM47E-STBD1 Regulons (14) R-2163, R-895, R-1709, R-2960, R-2651, R-3130, R-2057, R-1437, R-353, R-536, R-3, R-306, R-668, R-2361
NRAS	ETS1	activates	R-3	-1.52284	Pr-90 Genes (13) FOSL1, SMIM19, ZNRF2, BRF1, INSIG1, CHP1, S100A4, HDAC2, ZNF347, FAM229B, ZNF512, FAM47E-STBD1 Regulons (14) R-2163, R-895, R-1709, R-2960, R-2651, R-3130, R-2057, R-1437, R-353, R-536, R-3, R-306, R-668, R-2361
RNASeq_MAFA_Call	ETS1	activates	R-3	-1.52284	Pr-90 Genes (13) FOSL1, SMIM19, ZNRF2, BRF1, INSIG1, CHP1, S100A4, HDAC2, ZNF347, FAM229B, ZNF512, FAM47E-STBD1 Regulons (14) R-2163, R-895, R-1709, R-2960, R-2651, R-3130, R-2057, R-1437, R-353, R-536, R-3, R-306, R-668, R-2361
RNASeq_MAFB_Call	ETS1	activates	R-3	-1.52284	Pr-90 Genes (13) FOSL1, SMIM19, ZNRF2, BRF1, INSIG1, CHP1, S100A4, HDAC2, ZNF347, FAM229B, ZNF512, FAM47E-STBD1 Regulons (14) R-2163, R-895, R-1709, R-2960, R-2651, R-3130, R-2057, R-1437, R-353, R-536, R-3, R-306, R-668, R-2361
t(14;16)	ETS1	activates	R-3	-1.52284	Pr-90 Genes (13) FOSL1, SMIM19, ZNRF2, BRF1, INSIG1, CHP1, S100A4, HDAC2, ZNF347, FAM229B, ZNF512, FAM47E-STBD1 Regulons (14) R-2163, R-895, R-1709, R-2960, R-2651, R-3130, R-2057, R-1437, R-353, R-536, R-3, R-306, R-668, R-2361
SYNE2	ETS1	activates	R-3	-1.52284	Pr-90 Genes (13) FOSL1, SMIM19, ZNRF2, BRF1, INSIG1, CHP1, S100A4, HDAC2, ZNF347, FAM229B, ZNF512, FAM47E-STBD1 Regulons (14) R-2163, R-895, R-1709, R-2960, R-2651, R-3130, R-2057, R-1437, R-353, R-536, R-3, R-306, R-668, R-2361
MAX	ETS1	activates	R-2	-1.58579	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
RNASeq_CCND2_Call	ETS1	activates	R-2	-1.58579	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
RNASeq_FGFR3_Call	ETS1	activates	R-2	-1.58579	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
t(4;14)	ETS1	activates	R-2	-1.58579	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
t(4;14)_cytogenetic	ETS1	activates	R-2	-1.58579	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
CYLD	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
MAX	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
NFKB2	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
NRAS	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
PRKD2	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
RNASeq_CCND2_Call	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
RNASeq_FGFR3_Call	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
RNASeq_MAFB_Call	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
MYC	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
t(4;14)	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
ZNF208	ETS1	activates	R-1	-1.61913	Pr-64 Genes (6) NT5DC1, APOO, ANKFY1, FANCM, RAB42, ZNF425 Regulons (8) R-2979, R-2609, R-7, R-1073, R-1404, R-1, R-887, R-1856
NRAS	ETS1	represses	R-11	1.98573	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
RNASeq_CCND2_Call	ETS1	represses	R-11	1.98573	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
t(14;16)	ETS1	represses	R-11	1.98573	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
MYC	ETS1	represses	R-11	1.98573	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
ATM	ETS1	activates	R-9	2.77231	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
FAT2	ETS1	activates	R-9	2.77231	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
NRAS	ETS1	activates	R-9	2.77231	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
RNASeq_MAFA_Call	ETS1	activates	R-9	2.77231	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
RNASeq_MAFB_Call	ETS1	activates	R-9	2.77231	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
t(14;16)	ETS1	activates	R-9	2.77231	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
SYNE2	ETS1	activates	R-9	2.77231	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
CYLD	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
FGFR3	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
NFKB2	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
PRKD2	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_FGFR3_Call	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_MAFA_Call	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
RNASeq_MAFB_Call	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(14;16)	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(4;14)	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
SYNE2	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
t(4;14)_cytogenetic	ETS1	activates	R-6	3.22139	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625

ETS1 - ETS proto-oncogene 1, transcription factor

Causal Mechanistic Flows for Regulator: ETS1

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (5)

Regulons (5)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (13)

Regulons (16)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)

Genes (6)

Regulons (8)