Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation TACC2

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
ELF3down-regulatesR-21360.0676162Pr-1
TRAF4down-regulatesR-3037-0.0698997Pr-2
STAT3down-regulatesR-311-0.0731142Pr-135
ELF3down-regulatesR-21480.0747421Pr-3
MEF2Adown-regulatesR-18760.111678Pr-137
FOXJ3down-regulatesR-28790.135462Pr-4
TCF7L1down-regulatesR-3174-0.135953Pr-99
MEF2Adown-regulatesR-18840.142343Pr-23
VBP1up-regulatesR-2104-0.154186Pr-2
HBP1down-regulatesR-1826-0.154819Pr-1
ARID5Adown-regulatesR-610-0.170127Pr-135
FOXO1down-regulatesR-13950.17036Pr-1
ZEB1down-regulatesR-22520.171985Pr-117
CEBPGdown-regulatesR-453-0.180512Pr-99
ZNF410down-regulatesR-1940-0.201053Pr-133
NFIL3down-regulatesR-16850.22459Pr-1
GMEB2down-regulatesR-2156-0.237482Pr-0
FOXK1down-regulatesR-1207-0.237776Pr-5
FOXP1down-regulatesR-31370.242409Pr-5
CEBPGdown-regulatesR-436-0.258645Pr-2
ZBTB3up-regulatesR-1266-0.259836Pr-117
POU2F1down-regulatesR-78-0.272418Pr-2
FOXJ3down-regulatesR-28820.27442Pr-117
HBP1down-regulatesR-18320.278908Pr-14
MAFKdown-regulatesR-28010.283548Pr-40
FOXJ3down-regulatesR-2876-0.290335Pr-3
FOXK1down-regulatesR-1191-0.320198Pr-3
FOXJ3down-regulatesR-28720.323358Pr-1
ZNF281down-regulatesR-24900.3247Pr-3
ZNF281down-regulatesR-2479-0.333368Pr-2
HSF1down-regulatesR-49-0.350252Pr-2
FOXK1down-regulatesR-1192-0.353736Pr-0
HBP1down-regulatesR-18390.37241Pr-23
CEBPGdown-regulatesR-4510.388628Pr-117
MEF2Adown-regulatesR-1869-0.397022Pr-2
HBP1down-regulatesR-1831-0.397545Pr-2
ARID5Adown-regulatesR-596-0.400576Pr-1
MLXup-regulatesR-3197-0.407624Pr-0
FOXP1down-regulatesR-3121-0.417258Pr-3
ZBTB3up-regulatesR-1275-0.421961Pr-3
FOXK1down-regulatesR-11900.433468Pr-1
NFKB1down-regulatesR-1572-0.445091Pr-0
FOXK1down-regulatesR-1212-0.459405Pr-99
FOXP1down-regulatesR-3120-0.467693Pr-6
ELK1down-regulatesR-6360.485452Pr-0
CEBPGdown-regulatesR-435-0.497945Pr-6
FOXO1down-regulatesR-14060.499782Pr-18
MEF2Adown-regulatesR-1866-0.518528Pr-3
EWSR1down-regulatesR-2541-0.524632Pr-0
CEBPGdown-regulatesR-440-0.532761Pr-0
RREB1down-regulatesR-2285-0.538758Pr-3
NFKB1down-regulatesR-1574-0.538784Pr-2
FOXO1down-regulatesR-1417-0.539502Pr-3
ENSG00000168269down-regulatesR-1561-0.547918Pr-2
FOXP1down-regulatesR-3126-0.555658Pr-2
POU2F1down-regulatesR-690.559914Pr-1
ZBTB3up-regulatesR-1272-0.568661Pr-85
ZNF281down-regulatesR-24740.571768Pr-1
NFKB1down-regulatesR-1591-0.58346Pr-117
NR4A2down-regulatesR-1717-0.584893Pr-2
POU2F1down-regulatesR-71-0.58757Pr-3
HSF1down-regulatesR-50-0.599033Pr-16
ZBTB3up-regulatesR-12700.603274Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

FOXJ2down-regulatesR-14190.60607Pr-1
MEF2Adown-regulatesR-1865-0.617403Pr-6
RREB1down-regulatesR-2283-0.618728Pr-2
CEBPGdown-regulatesR-4340.620526Pr-1
RREB1down-regulatesR-2300-0.646333Pr-20
HIC2down-regulatesR-23710.647812Pr-117
ELF3down-regulatesR-2141-0.655011Pr-39
ZNF281down-regulatesR-2472-0.661858Pr-0
FOXO1down-regulatesR-1396-0.668881Pr-6
FOXJ3down-regulatesR-28890.679009Pr-23
FOXJ2down-regulatesR-1420-0.718874Pr-6
RREB1down-regulatesR-2296-0.757232Pr-9
FOXJ2down-regulatesR-14310.765091Pr-16
ELK1down-regulatesR-6480.765153Pr-99
RARBup-regulatesR-1107-0.777096Pr-9
TRAF4down-regulatesR-3033-0.781484Pr-0
CEBPGdown-regulatesR-443-0.789852Pr-4
POU2F1down-regulatesR-890.796686Pr-18
HSF1down-regulatesR-51-0.803656Pr-19
FOXO1down-regulatesR-1394-0.807027Pr-0
FOXK1down-regulatesR-1188-0.824193Pr-0
FOXK1down-regulatesR-1198-0.848863Pr-5
ELF3down-regulatesR-2135-0.853767Pr-0
RARAdown-regulatesR-159-0.860941Pr-9
EWSR1down-regulatesR-25420.861688Pr-1
FOXJ3down-regulatesR-2874-0.864638Pr-6
FOXJ3down-regulatesR-2873-0.871109Pr-2
CDC5Ldown-regulatesR-16300.87323Pr-1
HSF1down-regulatesR-52-0.875962Pr-9
STAT3down-regulatesR-3090.879665Pr-23
ZBTB3up-regulatesR-1264-0.885093Pr-9
POU2F1down-regulatesR-70-0.911223Pr-6
ERFdown-regulatesR-3370.913173Pr-135
ETV3down-regulatesR-25310.919835Pr-136
ZEB1down-regulatesR-22380.929885Pr-136
FOXP1down-regulatesR-3119-0.932927Pr-0
STAT3down-regulatesR-301-0.935216Pr-0
GABPB1down-regulatesR-1953-0.958675Pr-9
GABPB1down-regulatesR-19490.960779Pr-13
ERFdown-regulatesR-3310.969151Pr-136
ZSCAN16up-regulatesR-630-0.981764Pr-117
ENSG00000168269down-regulatesR-1560-0.982515Pr-0
FOXJ3down-regulatesR-2870-0.999227Pr-0
POU2F1down-regulatesR-66-1.00411Pr-0
NR4A2down-regulatesR-1718-1.0054Pr-9
GABPAup-regulatesR-1454-1.00665Pr-135
ELK1down-regulatesR-6391.02155Pr-13
ARID5Adown-regulatesR-595-1.02768Pr-0
FOXO1down-regulatesR-1398-1.0377Pr-14
MAFKdown-regulatesR-28001.04701Pr-13
NFKB1down-regulatesR-1585-1.04936Pr-4
CEBPGdown-regulatesR-433-1.08132Pr-0
MEF2Adown-regulatesR-18641.08745Pr-1
RREB1down-regulatesR-2298-1.11227Pr-6
FOXJ3down-regulatesR-28841.12637Pr-16
MAFKdown-regulatesR-2798-1.12983Pr-0
FOXJ2down-regulatesR-1418-1.1481Pr-0
ARID5Adown-regulatesR-599-1.1493Pr-2
FOXK1down-regulatesR-1189-1.15299Pr-2
POU2F1down-regulatesR-841.16934Pr-16
ELF2down-regulatesR-9791.18484Pr-135
BACH1down-regulatesR-4731.2099Pr-13
ERFdown-regulatesR-333-1.22378Pr-3
RREB1down-regulatesR-22901.22484Pr-16
ETV3down-regulatesR-2536-1.23178Pr-135
EWSR1down-regulatesR-2561-1.24127Pr-6
MEF2Adown-regulatesR-1878-1.24921Pr-9
ZNF281down-regulatesR-2488-1.25749Pr-0
MAFKdown-regulatesR-2806-1.27994Pr-9
ENSG00000168269down-regulatesR-15641.28019Pr-59
STAT3down-regulatesR-3021.28285Pr-1
FOXP1down-regulatesR-31281.29587Pr-16
ELK1down-regulatesR-654-1.31124Pr-59
GABPAup-regulatesR-14551.3231Pr-135
ZNF281down-regulatesR-2486-1.32496Pr-2
EWSR1down-regulatesR-25461.34254Pr-13
MEF2Adown-regulatesR-18711.35384Pr-16
RARAdown-regulatesR-1481.3622Pr-5
CEBPGdown-regulatesR-448-1.37561Pr-10
NFKB1down-regulatesR-1583-1.38564Pr-9
ELF3down-regulatesR-2143-1.40118Pr-9
E2F2up-regulatesR-29491.40408Pr-16
ZNF281down-regulatesR-2480-1.41308Pr-9
MLXup-regulatesR-31981.41369Pr-5
FOXO1down-regulatesR-1408-1.42694Pr-9
ELF3down-regulatesR-2153-1.43759Pr-0
EWSR1down-regulatesR-2553-1.45023Pr-0
FOXJ3down-regulatesR-2892-1.46097Pr-10
FOXK1down-regulatesR-1205-1.46171Pr-10
GABPAup-regulatesR-14521.4809Pr-136
HSF2down-regulatesR-3166-1.48665Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

GABPB1down-regulatesR-1956-1.51438Pr-135
RREB1down-regulatesR-2305-1.52832Pr-0
CEBPGdown-regulatesR-442-1.55989Pr-9
ZNF281down-regulatesR-2483-1.56826Pr-19
CEBPZup-regulatesR-757-1.57918Pr-10
RARAdown-regulatesR-1651.59669Pr-18
RREB1down-regulatesR-22821.60852Pr-5
ETV3down-regulatesR-25341.64074Pr-13
EWSR1down-regulatesR-2551-1.6617Pr-19
ELF3down-regulatesR-2149-1.67654Pr-10
ZNF281down-regulatesR-2491-1.68427Pr-10
ZEB1down-regulatesR-22491.69836Pr-1
FOXJ2down-regulatesR-14211.70246Pr-136
ELK1down-regulatesR-651-1.70669Pr-6
ZBTB4down-regulatesR-20901.72041Pr-117
HBP1down-regulatesR-18271.73978Pr-136
ZNF281down-regulatesR-24731.77923Pr-5
FOXK1down-regulatesR-1202-1.92921Pr-28
RREB1down-regulatesR-2302-1.95334Pr-10
HBP1down-regulatesR-18441.97565Pr-73
ELK1down-regulatesR-6502.0246Pr-99
MAFKdown-regulatesR-28082.02924Pr-1
ARID5Adown-regulatesR-602-2.062Pr-28
EP300down-regulatesR-2432-2.06462Pr-4
FOXJ2down-regulatesR-14332.07986Pr-8
ETV3down-regulatesR-2532-2.0819Pr-3
VBP1up-regulatesR-2099-2.16715Pr-4
TRAF4down-regulatesR-3035-2.1684Pr-17
RELdown-regulatesR-12792.17366Pr-16
SRFdown-regulatesR-1778-2.26549Pr-4
CDC5Ldown-regulatesR-1633-2.28378Pr-4
RELdown-regulatesR-1277-2.29016Pr-4
RELAdown-regulatesR-1463-2.30399Pr-4
RREB1down-regulatesR-2286-2.31249Pr-17
NFKB1down-regulatesR-1573-2.35352Pr-4
RARAdown-regulatesR-167-2.36681Pr-3
MAFKdown-regulatesR-2804-2.38089Pr-11
FOXO1down-regulatesR-1399-2.38797Pr-17
HBP1down-regulatesR-1845-2.40009Pr-6
MAFKdown-regulatesR-2799-2.41258Pr-4