Program

Causal Mechanistic Flows with regulons in program Pr-14

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
NEBdown-regulatesENSG00000054598activatesR-1002-0.041855828Pr-14
PTPRDdown-regulatesENSG00000054598activatesR-1002-0.041855828Pr-14
t(11;14)up-regulatesENSG00000054598activatesR-1002-0.041855828Pr-14
MYCdown-regulatesENSG00000054598activatesR-1002-0.041855828Pr-14
del17down-regulatesENSG00000054598activatesR-1002-0.041855828Pr-14
AHNAK2down-regulatesFOXJ2activatesR-14290.07025329Pr-14
t(11;14)up-regulatesFOXJ2activatesR-14290.07025329Pr-14
t(14;16)up-regulatesFOXJ2activatesR-14290.07025329Pr-14
amp1qup-regulatesFOXJ2activatesR-14290.07025329Pr-14
del13up-regulatesFOXJ2activatesR-14290.07025329Pr-14
AHNAK2down-regulatesRFX3activatesR-16590.1572714Pr-14
CMYA5down-regulatesRFX3activatesR-16590.1572714Pr-14
MYO10down-regulatesRFX3activatesR-16590.1572714Pr-14
NEBdown-regulatesRFX3activatesR-16590.1572714Pr-14
AHNAK2down-regulatesRUNX3activatesR-894-0.2014814Pr-14
PCDH10down-regulatesRUNX3activatesR-894-0.2014814Pr-14
t(11;14)up-regulatesRUNX3activatesR-894-0.2014814Pr-14
t(14;16)up-regulatesRUNX3activatesR-894-0.2014814Pr-14
AHNAK2down-regulatesPOU2F1activatesR-77-0.25983833Pr-14
CMYA5down-regulatesPOU2F1activatesR-77-0.25983833Pr-14
DNAH5down-regulatesPOU2F1activatesR-77-0.25983833Pr-14
KALRNdown-regulatesPOU2F1activatesR-77-0.25983833Pr-14
NEBdown-regulatesPOU2F1activatesR-77-0.25983833Pr-14
PTPRDdown-regulatesPOU2F1activatesR-77-0.25983833Pr-14
t(11;14)up-regulatesPOU2F1activatesR-77-0.25983833Pr-14
MYCdown-regulatesPOU2F1activatesR-77-0.25983833Pr-14
amp1qup-regulatesPOU2F1activatesR-77-0.25983833Pr-14
del13up-regulatesPOU2F1activatesR-77-0.25983833Pr-14
del17down-regulatesPOU2F1activatesR-77-0.25983833Pr-14
del17pdown-regulatesPOU2F1activatesR-77-0.25983833Pr-14
t(11;14)_cytogeneticup-regulatesPOU2F1activatesR-77-0.25983833Pr-14
AHNAK2down-regulatesHBP1activatesR-18320.27890818Pr-14
DNAH5down-regulatesHBP1activatesR-18320.27890818Pr-14
KALRNdown-regulatesHBP1activatesR-18320.27890818Pr-14
NEBdown-regulatesHBP1activatesR-18320.27890818Pr-14
PTPRDdown-regulatesHBP1activatesR-18320.27890818Pr-14
t(11;14)up-regulatesHBP1activatesR-18320.27890818Pr-14
SYNE1down-regulatesHBP1activatesR-18320.27890818Pr-14
TACC2down-regulatesHBP1activatesR-18320.27890818Pr-14
amp1qup-regulatesHBP1activatesR-18320.27890818Pr-14
del13up-regulatesHBP1activatesR-18320.27890818Pr-14
DIS3down-regulatesPAX6repressesR-1545-0.37477318Pr-14
FAM46Cup-regulatesPAX6repressesR-1545-0.37477318Pr-14
IRF4down-regulatesPAX6repressesR-1545-0.37477318Pr-14
NEBup-regulatesPAX6repressesR-1545-0.37477318Pr-14
t(11;14)down-regulatesPAX6repressesR-1545-0.37477318Pr-14
t(14;16)down-regulatesPAX6repressesR-1545-0.37477318Pr-14
MYCup-regulatesPAX6repressesR-1545-0.37477318Pr-14
amp1qdown-regulatesPAX6repressesR-1545-0.37477318Pr-14
del13down-regulatesPAX6repressesR-1545-0.37477318Pr-14
t(11;14)_cytogeneticdown-regulatesPAX6repressesR-1545-0.37477318Pr-14
AHNAK2down-regulatesIRF1activatesR-184-0.38616929Pr-14
t(11;14)up-regulatesIRF1activatesR-184-0.38616929Pr-14
t(14;16)up-regulatesIRF1activatesR-184-0.38616929Pr-14
AHNAK2down-regulatesRREB1activatesR-2284-0.43643321Pr-14
t(4;14)down-regulatesRREB1activatesR-2284-0.43643321Pr-14
SETD2down-regulatesRREB1activatesR-2284-0.43643321Pr-14
SYNE1down-regulatesRREB1activatesR-2284-0.43643321Pr-14
TP53down-regulatesRREB1activatesR-2284-0.43643321Pr-14
DNAH5down-regulatesIRX3activatesR-2223-0.52211714Pr-14
NEBdown-regulatesIRX3activatesR-2223-0.52211714Pr-14
del17down-regulatesIRX3activatesR-2223-0.52211714Pr-14
t(14;16)_cytogeneticdown-regulatesIRX3activatesR-2223-0.52211714Pr-14
DIS3up-regulatesPRDM1activatesR-20750.61252822Pr-14
t(14;16)up-regulatesPRDM1activatesR-20750.61252822Pr-14
amp1qup-regulatesPRDM1activatesR-20750.61252822Pr-14
del13up-regulatesPRDM1activatesR-20750.61252822Pr-14
AHNAK2down-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
DNAH5down-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
NEBdown-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
PTPRDdown-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
t(11;14)up-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
amp1qup-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
del13up-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
del17down-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
del17pdown-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
t(11;14)_cytogeneticup-regulatesFOXJ3activatesR-2878-0.65180232Pr-14
MAGI1down-regulatesSPI1activatesR-2606-0.75983331Pr-14
NEBdown-regulatesSPI1activatesR-2606-0.75983331Pr-14
PTPRDdown-regulatesSPI1activatesR-2606-0.75983331Pr-14
t(11;14)up-regulatesSPI1activatesR-2606-0.75983331Pr-14
MYCdown-regulatesSPI1activatesR-2606-0.75983331Pr-14
SYNE1down-regulatesSPI1activatesR-2606-0.75983331Pr-14
AHNAK2down-regulatesFOXO1activatesR-1398-1.037731Pr-14
NEBdown-regulatesFOXO1activatesR-1398-1.037731Pr-14
PTPRDdown-regulatesFOXO1activatesR-1398-1.037731Pr-14
t(11;14)up-regulatesFOXO1activatesR-1398-1.037731Pr-14
TACC2down-regulatesFOXO1activatesR-1398-1.037731Pr-14
del13up-regulatesFOXO1activatesR-1398-1.037731Pr-14
IRF4down-regulatesDBPrepressesR-29521.090359Pr-14
t(11;14)down-regulatesDBPrepressesR-29521.090359Pr-14
amp1qdown-regulatesDBPrepressesR-29521.090359Pr-14
NEBdown-regulatesZNF410activatesR-1932-1.2660112Pr-14
t(14;16)up-regulatesZNF410activatesR-1932-1.2660112Pr-14
amp1qup-regulatesZNF410activatesR-1932-1.2660112Pr-14
del13up-regulatesZNF410activatesR-1932-1.2660112Pr-14
AHNAK2down-regulatesTCF7L1activatesR-3170-2.278929Pr-14
DNAH5down-regulatesTCF7L1activatesR-3170-2.278929Pr-14
NEBdown-regulatesTCF7L1activatesR-3170-2.278929Pr-14
t(11;14)up-regulatesTCF7L1activatesR-3170-2.278929Pr-14
SETD2down-regulatesTCF7L1activatesR-3170-2.278929Pr-14
SYNE2down-regulatesTCF7L1activatesR-3170-2.278929Pr-14
TP53down-regulatesTCF7L1activatesR-3170-2.278929Pr-14
del13up-regulatesTCF7L1activatesR-3170-2.278929Pr-14
AHNAK2up-regulatesZNF282repressesR-20142.856938Pr-14
DIS3down-regulatesZNF282repressesR-20142.856938Pr-14
t(11;14)down-regulatesZNF282repressesR-20142.856938Pr-14
MYCup-regulatesZNF282repressesR-20142.856938Pr-14
SYNE1up-regulatesZNF282repressesR-20142.856938Pr-14

Regulons in program Pr-14

Regulon Cox Hazard Ratio # genes # causal flows
R-1002-0.0418558285
R-14290.070253295
R-16590.15727144
R-894-0.20148144
R-77-0.2598383313
R-18320.2789081810
R-1545-0.3747731810
R-184-0.386169293
R-2284-0.436433215
R-2223-0.522117144
R-20750.612528224
R-2878-0.6518023210
R-2606-0.759833316
R-1398-1.0377316
R-29521.0903593
R-1932-1.26601124
R-3170-2.2789298
R-20142.8569385

Genes in program Pr-14

EnsEMBL IdEntrez IdPreferred
ENSG00000175606 54968TMEM70
ENSG00000176014 84617TUBB6
ENSG00000176903 9240PNMA1
ENSG00000177303 57513CASKIN2
ENSG00000177721 389289ANXA2R
ENSG00000178053 4291MLF1
ENSG00000179361 10620ARID3B
ENSG00000179520 246213SLC17A8
ENSG00000180340 2535FZD2
ENSG00000181690 5324PLAG1
ENSG00000183023 6546SLC8A1
ENSG00000183722
ENSG00000185033 10509SEMA4B
ENSG00000188747 10811NOXA1
ENSG00000196139 8644AKR1C3
ENSG00000197632
ENSG00000254858 84769MPV17L2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions