Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ZNF281 - zinc finger protein 281

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
23528 ENSG00000162702 ZNF281 Q9Y2X9

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ZNF281

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
DMDZNF281activatesR-24900.3247Pr-3
NEBZNF281activatesR-24900.3247Pr-3
PTPRDZNF281activatesR-24900.3247Pr-3
t(11;14)ZNF281activatesR-24900.3247Pr-3
SYNE1ZNF281activatesR-24900.3247Pr-3
TACC2ZNF281activatesR-24900.3247Pr-3
del13ZNF281activatesR-24900.3247Pr-3
t(11;14)_cytogeneticZNF281activatesR-24900.3247Pr-3
AHNAK2ZNF281activatesR-2479-0.333368Pr-2
CMYA5ZNF281activatesR-2479-0.333368Pr-2
MACF1ZNF281activatesR-2479-0.333368Pr-2
NEBZNF281activatesR-2479-0.333368Pr-2
PCDH10ZNF281activatesR-2479-0.333368Pr-2
PTPRDZNF281activatesR-2479-0.333368Pr-2
t(11;14)ZNF281activatesR-2479-0.333368Pr-2
RNASeq_MAFB_CallZNF281activatesR-2479-0.333368Pr-2
t(4;14)ZNF281activatesR-2479-0.333368Pr-2
SYNE1ZNF281activatesR-2479-0.333368Pr-2
TACC2ZNF281activatesR-2479-0.333368Pr-2
del13ZNF281activatesR-2479-0.333368Pr-2
t(11;14)_cytogeneticZNF281activatesR-2479-0.333368Pr-2
DMDZNF281activatesR-24740.571768Pr-1
NEBZNF281activatesR-24740.571768Pr-1
TACC2ZNF281activatesR-24740.571768Pr-1
amp1qZNF281activatesR-24740.571768Pr-1
del13ZNF281activatesR-24740.571768Pr-1
AHNAK2ZNF281activatesR-2485-0.64174Pr-4
DMDZNF281activatesR-2485-0.64174Pr-4
PTPRDZNF281activatesR-2485-0.64174Pr-4
RNASeq_MAFB_CallZNF281activatesR-2485-0.64174Pr-4
amp1qZNF281activatesR-2485-0.64174Pr-4
del13ZNF281activatesR-2485-0.64174Pr-4
AHNAK2ZNF281activatesR-2472-0.661858Pr-0
CMYA5ZNF281activatesR-2472-0.661858Pr-0
FAT3ZNF281activatesR-2472-0.661858Pr-0
MACF1ZNF281activatesR-2472-0.661858Pr-0
NEBZNF281activatesR-2472-0.661858Pr-0
PCDH10ZNF281activatesR-2472-0.661858Pr-0
PTPRDZNF281activatesR-2472-0.661858Pr-0
t(11;14)ZNF281activatesR-2472-0.661858Pr-0
t(4;14)ZNF281activatesR-2472-0.661858Pr-0
SYNE1ZNF281activatesR-2472-0.661858Pr-0
TACC2ZNF281activatesR-2472-0.661858Pr-0
amp1qZNF281activatesR-2472-0.661858Pr-0
del13ZNF281activatesR-2472-0.661858Pr-0
RNASeq_FGFR3_CallZNF281repressesR-24940.868452Pr-37
t(4;14)ZNF281repressesR-24940.868452Pr-37
amp1qZNF281repressesR-24940.868452Pr-37
AHNAK2ZNF281activatesR-2493-0.959313Pr-27
RNASeq_FGFR3_CallZNF281activatesR-2493-0.959313Pr-27
t(4;14)ZNF281activatesR-2493-0.959313Pr-27
amp1qZNF281activatesR-2493-0.959313Pr-27
del13ZNF281activatesR-2493-0.959313Pr-27
AHNAK2ZNF281activatesR-2488-1.25749Pr-0
FAT3ZNF281activatesR-2488-1.25749Pr-0
MACF1ZNF281activatesR-2488-1.25749Pr-0
NEBZNF281activatesR-2488-1.25749Pr-0
PTPRDZNF281activatesR-2488-1.25749Pr-0
RNASeq_MAFB_CallZNF281activatesR-2488-1.25749Pr-0
SYNE1ZNF281activatesR-2488-1.25749Pr-0
TACC2ZNF281activatesR-2488-1.25749Pr-0
del13ZNF281activatesR-2488-1.25749Pr-0
CMYA5ZNF281activatesR-2486-1.32496Pr-2
DMDZNF281activatesR-2486-1.32496Pr-2
FAT3ZNF281activatesR-2486-1.32496Pr-2
t(11;14)ZNF281activatesR-2486-1.32496Pr-2
TACC2ZNF281activatesR-2486-1.32496Pr-2
amp1qZNF281activatesR-2486-1.32496Pr-2
del13ZNF281activatesR-2486-1.32496Pr-2
AHNAK2ZNF281activatesR-2480-1.41308Pr-9
CMYA5ZNF281activatesR-2480-1.41308Pr-9
FAT3ZNF281activatesR-2480-1.41308Pr-9
MACF1ZNF281activatesR-2480-1.41308Pr-9
PCDH10ZNF281activatesR-2480-1.41308Pr-9
PTPRDZNF281activatesR-2480-1.41308Pr-9
t(11;14)ZNF281activatesR-2480-1.41308Pr-9
RNASeq_MAFB_CallZNF281activatesR-2480-1.41308Pr-9
TACC2ZNF281activatesR-2480-1.41308Pr-9
AHNAK2ZNF281activatesR-2483-1.56826Pr-19
FAT3ZNF281activatesR-2483-1.56826Pr-19
MACF1ZNF281activatesR-2483-1.56826Pr-19
PCDH10ZNF281activatesR-2483-1.56826Pr-19
PTPRDZNF281activatesR-2483-1.56826Pr-19
TACC2ZNF281activatesR-2483-1.56826Pr-19
AHNAK2ZNF281activatesR-2491-1.68427Pr-10
CMYA5ZNF281activatesR-2491-1.68427Pr-10
FAT3ZNF281activatesR-2491-1.68427Pr-10
MACF1ZNF281activatesR-2491-1.68427Pr-10
PCDH10ZNF281activatesR-2491-1.68427Pr-10
t(11;14)ZNF281activatesR-2491-1.68427Pr-10
RNASeq_FGFR3_CallZNF281activatesR-2491-1.68427Pr-10
t(4;14)ZNF281activatesR-2491-1.68427Pr-10
TACC2ZNF281activatesR-2491-1.68427Pr-10
t(11;14)_cytogeneticZNF281activatesR-2491-1.68427Pr-10
DMDZNF281activatesR-24731.77923Pr-5
NEBZNF281activatesR-24731.77923Pr-5
t(11;14)ZNF281activatesR-24731.77923Pr-5
RNASeq_FGFR3_CallZNF281activatesR-24731.77923Pr-5
t(4;14)ZNF281activatesR-24731.77923Pr-5
TACC2ZNF281activatesR-24731.77923Pr-5
amp1qZNF281activatesR-24731.77923Pr-5
del13ZNF281activatesR-24731.77923Pr-5
t(11;14)_cytogeneticZNF281activatesR-24731.77923Pr-5
NEBZNF281activatesR-24892.06258Pr-8
SYNE1ZNF281activatesR-24892.06258Pr-8
NEBZNF281activatesR-24762.2168Pr-125
t(11;14)ZNF281activatesR-24762.2168Pr-125
t(11;14)_cytogeneticZNF281activatesR-24762.2168Pr-125
FAT3ZNF281activatesR-2482-2.34579Pr-30
t(11;14)ZNF281activatesR-2482-2.34579Pr-30
del13ZNF281activatesR-2482-2.34579Pr-30
t(11;14)_cytogeneticZNF281activatesR-2482-2.34579Pr-30
NEBZNF281repressesR-2481-2.52054Pr-103
t(11;14)ZNF281repressesR-2481-2.52054Pr-103
RNASeq_FGFR3_CallZNF281repressesR-2481-2.52054Pr-103
t(4;14)ZNF281repressesR-2481-2.52054Pr-103
t(11;14)_cytogeneticZNF281repressesR-2481-2.52054Pr-103
AHNAK2ZNF281activatesR-2487-2.70466Pr-4
CMYA5ZNF281activatesR-2487-2.70466Pr-4
FAT3ZNF281activatesR-2487-2.70466Pr-4
MACF1ZNF281activatesR-2487-2.70466Pr-4
NEBZNF281activatesR-2487-2.70466Pr-4
PTPRDZNF281activatesR-2487-2.70466Pr-4
t(11;14)ZNF281activatesR-2487-2.70466Pr-4
RNASeq_MAFB_CallZNF281activatesR-2487-2.70466Pr-4
SYNE1ZNF281activatesR-2487-2.70466Pr-4
TACC2ZNF281activatesR-2487-2.70466Pr-4
del13ZNF281activatesR-2487-2.70466Pr-4
FAT3ZNF281activatesR-2478-2.93787Pr-86
del13ZNF281activatesR-2478-2.93787Pr-86
MACF1ZNF281repressesR-2492-3.05072Pr-85
t(11;14)ZNF281repressesR-2492-3.05072Pr-85
RNASeq_FGFR3_CallZNF281repressesR-2492-3.05072Pr-85
t(4;14)ZNF281repressesR-2492-3.05072Pr-85
PTPRDZNF281activatesR-24753.21369Pr-108
RNASeq_FGFR3_CallZNF281activatesR-24753.21369Pr-108
t(4;14)ZNF281activatesR-24753.21369Pr-108
amp1qZNF281activatesR-24753.21369Pr-108
del13ZNF281activatesR-24753.21369Pr-108
RNASeq_FGFR3_CallZNF281activatesR-24773.21388Pr-75
t(4;14)ZNF281activatesR-24773.21388Pr-75
amp1qZNF281activatesR-24773.21388Pr-75
del13ZNF281activatesR-24773.21388Pr-75
FAT3ZNF281activatesR-2496-3.6494Pr-104
amp1qZNF281activatesR-2496-3.6494Pr-104
del13ZNF281activatesR-2496-3.6494Pr-104
AHNAK2ZNF281activatesR-2484-3.91355Pr-20
CMYA5ZNF281activatesR-2484-3.91355Pr-20
FAT3ZNF281activatesR-2484-3.91355Pr-20
NEBZNF281activatesR-2484-3.91355Pr-20
t(11;14)ZNF281activatesR-2484-3.91355Pr-20
SYNE1ZNF281activatesR-2484-3.91355Pr-20
TACC2ZNF281activatesR-2484-3.91355Pr-20
t(11;14)_cytogeneticZNF281activatesR-2484-3.91355Pr-20
DMDZNF281activatesR-24955.48531Pr-48
RNASeq_FGFR3_CallZNF281activatesR-24955.48531Pr-48
t(4;14)ZNF281activatesR-24955.48531Pr-48
amp1qZNF281activatesR-24955.48531Pr-48
del13ZNF281activatesR-24955.48531Pr-48

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.