Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation DMD

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
SMAD3up-regulatesR-2966-0.0660624Pr-85
ELF3up-regulatesR-21360.0676162Pr-1
ZNF281up-regulatesR-24900.3247Pr-3
HMBOX1up-regulatesR-23820.378178Pr-62
NFE2L2down-regulatesR-19080.425689Pr-4
ETV2down-regulatesR-15110.447542Pr-62
FOXP1up-regulatesR-3126-0.555658Pr-2
ZNF281up-regulatesR-24740.571768Pr-1
FOXP1up-regulatesR-31350.58463Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

ZNF281up-regulatesR-2485-0.64174Pr-4
MYBup-regulatesR-6150.668149Pr-85
XBP1down-regulatesR-3065-0.830078Pr-65
EWSR1up-regulatesR-25420.861688Pr-1
MYBup-regulatesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ELK4up-regulatesR-7681.07813Pr-24
ETS1up-regulatesR-131.07999Pr-93
FOXP1up-regulatesR-31251.11357Pr-87
HMBOX1up-regulatesR-23851.11927Pr-18
ARID5Aup-regulatesR-607-1.1537Pr-10
THRAup-regulatesR-60-1.15946Pr-0
FOXP1up-regulatesR-31311.21746Pr-93
ARNTup-regulatesR-20381.28594Pr-5
FOXP1up-regulatesR-31281.29587Pr-16
ZNF281up-regulatesR-2486-1.32496Pr-2
DR1up-regulatesR-421.38624Pr-5
SATB1down-regulatesR-10741.38828Pr-111
FOXP1up-regulatesR-31231.51064Pr-24
NFE2L2down-regulatesR-1909-1.53545Pr-101
MYBup-regulatesR-6171.6152Pr-87
MYBup-regulatesR-6231.65419Pr-96
ZNF281up-regulatesR-24731.77923Pr-5
HMBOX1up-regulatesR-23771.82796Pr-5
SMAD3up-regulatesR-2967-1.98807Pr-139
SMAD3up-regulatesR-29652.28284Pr-137
EWSR1up-regulatesR-25602.38471Pr-82

Genes (2)

ZBED5

Regulons (3)

R-2436, R-2560, R-963

FLI1down-regulatesR-7932.52326Pr-96
ETV3up-regulatesR-25332.79874Pr-24
PLAG1down-regulatesR-1528-2.89171Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

NFE2L2down-regulatesR-19133.00873Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

HMBOX1up-regulatesR-23813.13315Pr-48
BACH2up-regulatesR-2844-3.59383Pr-99
EWSR1up-regulatesR-25494.472Pr-48
ARID5Aup-regulatesR-606-4.76793Pr-99
ELF3up-regulatesR-21525.41188Pr-48
ZNF281up-regulatesR-24955.48531Pr-48
EWSR1up-regulatesR-2545-5.82984Pr-36
PLAG1down-regulatesR-1523-6.09323Pr-135
MYBup-regulatesR-6148.54513Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions