Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

IRF1 - interferon regulatory factor 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
3659 ENSG00000125347 IRF1 A0A7P0T8P0

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: IRF1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2IRF1activatesR-177-0.0462797Pr-11
BAI3IRF1activatesR-177-0.0462797Pr-11
AHNAK2IRF1activatesR-180-0.0848453Pr-0
KRASIRF1activatesR-180-0.0848453Pr-0
NRASIRF1activatesR-180-0.0848453Pr-0
t(11;14)IRF1activatesR-180-0.0848453Pr-0
RNASeq_FGFR3_CallIRF1activatesR-180-0.0848453Pr-0
t(11;14)_cytogeneticIRF1activatesR-180-0.0848453Pr-0
AHNAK2IRF1repressesR-1860.0932494Pr-137
del1pIRF1repressesR-1860.0932494Pr-137
AHNAK2IRF1activatesR-183-0.261893Pr-2
t(11;14)IRF1activatesR-183-0.261893Pr-2
t(14;16)IRF1activatesR-183-0.261893Pr-2
t(11;14)_cytogeneticIRF1activatesR-183-0.261893Pr-2
AHNAK2IRF1activatesR-1910.280655Pr-16
BAI3IRF1activatesR-1910.280655Pr-16
t(11;14)IRF1activatesR-1910.280655Pr-16
t(14;16)IRF1activatesR-1910.280655Pr-16
del1pIRF1activatesR-1910.280655Pr-16
t(11;14)_cytogeneticIRF1activatesR-1910.280655Pr-16
NRASIRF1repressesR-1900.33011Pr-56
AHNAK2IRF1activatesR-184-0.386169Pr-14
t(11;14)IRF1activatesR-184-0.386169Pr-14
t(14;16)IRF1activatesR-184-0.386169Pr-14
NRASIRF1repressesR-193-0.549869Pr-136
t(14;16)IRF1activatesR-178-0.803264Pr-6
AHNAK2IRF1activatesR-1820.909345Pr-124
DNAH10IRF1activatesR-1820.909345Pr-124
DSTIRF1activatesR-1820.909345Pr-124
KIAA1244IRF1activatesR-1820.909345Pr-124
KRASIRF1activatesR-1820.909345Pr-124
NRASIRF1activatesR-1820.909345Pr-124
PRDM1IRF1activatesR-1820.909345Pr-124
t(11;14)IRF1activatesR-1820.909345Pr-124
t(14;16)IRF1activatesR-1820.909345Pr-124
TP53IRF1activatesR-1820.909345Pr-124
TRAF3IRF1activatesR-1820.909345Pr-124
t(11;14)_cytogeneticIRF1activatesR-1820.909345Pr-124
AHNAK2IRF1activatesR-175-0.989721Pr-0
t(11;14)IRF1activatesR-175-0.989721Pr-0
AHNAK2IRF1activatesR-192-1.06726Pr-40
DSTIRF1activatesR-192-1.06726Pr-40
FGFR3IRF1activatesR-192-1.06726Pr-40
PRDM1IRF1activatesR-192-1.06726Pr-40
RNASeq_FGFR3_CallIRF1activatesR-192-1.06726Pr-40
TP53IRF1activatesR-192-1.06726Pr-40
TRAF3IRF1activatesR-192-1.06726Pr-40
AHNAK2IRF1activatesR-195-1.1496Pr-9
NRASIRF1activatesR-195-1.1496Pr-9
t(11;14)IRF1activatesR-195-1.1496Pr-9
TRAF3IRF1activatesR-195-1.1496Pr-9
AHNAK2IRF1activatesR-1941.26041Pr-3
FGFR3IRF1activatesR-1941.26041Pr-3
KRASIRF1activatesR-1941.26041Pr-3
NRASIRF1activatesR-1941.26041Pr-3
t(11;14)IRF1activatesR-1941.26041Pr-3
RNASeq_FGFR3_CallIRF1activatesR-1941.26041Pr-3
t(11;14)_cytogeneticIRF1activatesR-1941.26041Pr-3
FGFR3IRF1activatesR-189-1.28236Pr-12
PRDM1IRF1activatesR-189-1.28236Pr-12
PRKD2IRF1activatesR-189-1.28236Pr-12
RNASeq_FGFR3_CallIRF1activatesR-189-1.28236Pr-12
t(14;16)IRF1activatesR-189-1.28236Pr-12
FGFR3IRF1repressesR-188-1.56891Pr-99
KRASIRF1repressesR-188-1.56891Pr-99
PRKD2IRF1repressesR-188-1.56891Pr-99
t(11;14)IRF1repressesR-188-1.56891Pr-99
RNASeq_FGFR3_CallIRF1repressesR-188-1.56891Pr-99
t(14;16)IRF1repressesR-188-1.56891Pr-99
t(11;14)_cytogeneticIRF1repressesR-188-1.56891Pr-99
AHNAK2IRF1activatesR-199-1.64611Pr-124
BAI3IRF1activatesR-199-1.64611Pr-124
FGFR3IRF1activatesR-199-1.64611Pr-124
t(11;14)IRF1activatesR-199-1.64611Pr-124
RNASeq_FGFR3_CallIRF1activatesR-199-1.64611Pr-124
TRAF3IRF1activatesR-199-1.64611Pr-124
DNAH10IRF1activatesR-1962.01864Pr-108
FGFR3IRF1activatesR-1962.01864Pr-108
KIAA1244IRF1activatesR-1962.01864Pr-108
PRKD2IRF1activatesR-1962.01864Pr-108
t(11;14)IRF1activatesR-1962.01864Pr-108
RNASeq_FGFR3_CallIRF1activatesR-1962.01864Pr-108
t(11;14)_cytogeneticIRF1activatesR-1962.01864Pr-108
FGFR3IRF1activatesR-1982.0921Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

KIAA1244IRF1activatesR-1982.0921Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

PRKD2IRF1activatesR-1982.0921Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

t(11;14)IRF1activatesR-1982.0921Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RNASeq_FGFR3_CallIRF1activatesR-1982.0921Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

del1pIRF1activatesR-1982.0921Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

AHNAK2IRF1activatesR-176-2.33755Pr-4
NRASIRF1activatesR-176-2.33755Pr-4
BAI3IRF1activatesR-1852.8096Pr-123
DNAH10IRF1activatesR-1852.8096Pr-123
FGFR3IRF1activatesR-1852.8096Pr-123
KIAA1244IRF1activatesR-1852.8096Pr-123
PRKD2IRF1activatesR-1852.8096Pr-123
t(11;14)IRF1activatesR-1852.8096Pr-123
RNASeq_FGFR3_CallIRF1activatesR-1852.8096Pr-123
TP53IRF1activatesR-1852.8096Pr-123
t(11;14)_cytogeneticIRF1activatesR-1852.8096Pr-123
DNAH10IRF1activatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

KRASIRF1activatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)IRF1activatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

TP53IRF1activatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

TRAF3IRF1activatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)_cytogeneticIRF1activatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

FGFR3IRF1activatesR-1813.21843Pr-8
KIAA1244IRF1activatesR-1813.21843Pr-8
t(11;14)IRF1activatesR-1813.21843Pr-8
RNASeq_FGFR3_CallIRF1activatesR-1813.21843Pr-8
t(14;16)IRF1activatesR-1813.21843Pr-8
TRAF3IRF1activatesR-1813.21843Pr-8
del1pIRF1activatesR-1813.21843Pr-8
t(11;14)_cytogeneticIRF1activatesR-1813.21843Pr-8
BAI3IRF1activatesR-1793.48115Pr-108
DNAH10IRF1activatesR-1793.48115Pr-108
FGFR3IRF1activatesR-1793.48115Pr-108
KIAA1244IRF1activatesR-1793.48115Pr-108
PRKD2IRF1activatesR-1793.48115Pr-108
RNASeq_FGFR3_CallIRF1activatesR-1793.48115Pr-108
del1pIRF1activatesR-1793.48115Pr-108
NRASIRF1activatesR-187-3.69641Pr-100
TRAF3IRF1activatesR-187-3.69641Pr-100

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.