Program

Causal Mechanistic Flows with regulons in program Pr-124

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesFOXO1activatesR-14000.10647329Pr-124
MYO10down-regulatesFOXO1activatesR-14000.10647329Pr-124
NEBdown-regulatesFOXO1activatesR-14000.10647329Pr-124
t(11;14)up-regulatesFOXO1activatesR-14000.10647329Pr-124
AHNAK2down-regulatesFOXJ2activatesR-14250.27336733Pr-124
t(11;14)up-regulatesFOXJ2activatesR-14250.27336733Pr-124
t(14;16)up-regulatesFOXJ2activatesR-14250.27336733Pr-124
AHNAK2down-regulatesSPDEFactivatesR-19620.3300115Pr-124
AHNAK2down-regulatesHBP1activatesR-18280.34863723Pr-124
PCDH10down-regulatesHBP1activatesR-18280.34863723Pr-124
t(11;14)up-regulatesHBP1activatesR-18280.34863723Pr-124
AHNAK2down-regulatesIKZF1activatesR-9910.57370113Pr-124
DNAH5down-regulatesIKZF1activatesR-9910.57370113Pr-124
MACF1down-regulatesIKZF1activatesR-9910.57370113Pr-124
t(11;14)up-regulatesIKZF1activatesR-9910.57370113Pr-124
t(11;14)_cytogeneticup-regulatesIKZF1activatesR-9910.57370113Pr-124
AHNAK2down-regulatesIRF7activatesR-10830.67400125Pr-124
DSTdown-regulatesIRF7activatesR-10830.67400125Pr-124
FLGdown-regulatesIRF7activatesR-10830.67400125Pr-124
NRASup-regulatesIRF7activatesR-10830.67400125Pr-124
TP53up-regulatesIRF7activatesR-10830.67400125Pr-124
TRAF3down-regulatesIRF7activatesR-10830.67400125Pr-124
amp1qdown-regulatesIRF7activatesR-10830.67400125Pr-124
AHNAK2down-regulatesNFKB1activatesR-15770.68599718Pr-124
MACF1down-regulatesNFKB1activatesR-15770.68599718Pr-124
PCDH10down-regulatesNFKB1activatesR-15770.68599718Pr-124
AHNAK2down-regulatesPOU2F1activatesR-720.69144237Pr-124
MYO10down-regulatesPOU2F1activatesR-720.69144237Pr-124
t(11;14)up-regulatesPOU2F1activatesR-720.69144237Pr-124
t(11;14)_cytogeneticup-regulatesPOU2F1activatesR-720.69144237Pr-124
FGFR3up-regulatesSTAT5AactivatesR-21580.70229519Pr-124
t(11;14)up-regulatesSTAT5AactivatesR-21580.70229519Pr-124
t(14;16)up-regulatesSTAT5AactivatesR-21580.70229519Pr-124
t(4;14)up-regulatesSTAT5AactivatesR-21580.70229519Pr-124
TRAF3down-regulatesSTAT5AactivatesR-21580.70229519Pr-124
del1pup-regulatesSTAT5AactivatesR-21580.70229519Pr-124
t(11;14)_cytogeneticup-regulatesSTAT5AactivatesR-21580.70229519Pr-124
DSTdown-regulatesSTAT1activatesR-30690.78582222Pr-124
FGFR3up-regulatesSTAT1activatesR-30690.78582222Pr-124
FLGdown-regulatesSTAT1activatesR-30690.78582222Pr-124
NFKB2up-regulatesSTAT1activatesR-30690.78582222Pr-124
RNASeq_FGFR3_Callup-regulatesSTAT1activatesR-30690.78582222Pr-124
t(4;14)up-regulatesSTAT1activatesR-30690.78582222Pr-124
TP53up-regulatesSTAT1activatesR-30690.78582222Pr-124
TRAF3down-regulatesSTAT1activatesR-30690.78582222Pr-124
AHNAK2down-regulatesMAFKactivatesR-28140.8476317Pr-124
DNAH5down-regulatesMAFKactivatesR-28140.8476317Pr-124
PTPRDdown-regulatesMAFKactivatesR-28140.8476317Pr-124
AHNAK2down-regulatesIRF9activatesR-11490.85183926Pr-124
DSTdown-regulatesIRF9activatesR-11490.85183926Pr-124
FGFR3up-regulatesIRF9activatesR-11490.85183926Pr-124
NFKB2up-regulatesIRF9activatesR-11490.85183926Pr-124
PRDM1up-regulatesIRF9activatesR-11490.85183926Pr-124
RNASeq_FGFR3_Callup-regulatesIRF9activatesR-11490.85183926Pr-124
TP53up-regulatesIRF9activatesR-11490.85183926Pr-124
TRAF3down-regulatesIRF9activatesR-11490.85183926Pr-124
t(14;16)up-regulatesCDC5LactivatesR-16310.8954458Pr-124
AHNAK2down-regulatesIRF1activatesR-1820.90934530Pr-124
DNAH10up-regulatesIRF1activatesR-1820.90934530Pr-124
DSTdown-regulatesIRF1activatesR-1820.90934530Pr-124
KIAA1244down-regulatesIRF1activatesR-1820.90934530Pr-124
KRASup-regulatesIRF1activatesR-1820.90934530Pr-124
NRASup-regulatesIRF1activatesR-1820.90934530Pr-124
PRDM1up-regulatesIRF1activatesR-1820.90934530Pr-124
t(11;14)up-regulatesIRF1activatesR-1820.90934530Pr-124
t(14;16)up-regulatesIRF1activatesR-1820.90934530Pr-124
TP53up-regulatesIRF1activatesR-1820.90934530Pr-124
TRAF3down-regulatesIRF1activatesR-1820.90934530Pr-124
t(11;14)_cytogeneticup-regulatesIRF1activatesR-1820.90934530Pr-124
AHNAK2up-regulatesARID3ArepressesR-13400.9130418Pr-124
DSTup-regulatesARID3ArepressesR-13400.9130418Pr-124
KRASdown-regulatesARID3ArepressesR-13400.9130418Pr-124
NRASdown-regulatesARID3ArepressesR-13400.9130418Pr-124
t(11;14)down-regulatesARID3ArepressesR-13400.9130418Pr-124
TRAF3up-regulatesARID3ArepressesR-13400.9130418Pr-124
AHNAK2down-regulatesTRAF4activatesR-30341.0676819Pr-124
KRASup-regulatesTRAF4activatesR-30341.0676819Pr-124
MAXdown-regulatesTRAF4activatesR-30341.0676819Pr-124
MYO10down-regulatesTRAF4activatesR-30341.0676819Pr-124
NRASup-regulatesTRAF4activatesR-30341.0676819Pr-124
PCDH10down-regulatesTRAF4activatesR-30341.0676819Pr-124
t(11;14)up-regulatesTRAF4activatesR-30341.0676819Pr-124
RNASeq_CCND2_Calldown-regulatesTRAF4activatesR-30341.0676819Pr-124
TRAF3down-regulatesTRAF4activatesR-30341.0676819Pr-124
t(11;14)up-regulatesFOXP1activatesR-3139-1.0958611Pr-124
del13up-regulatesFOXP1activatesR-3139-1.0958611Pr-124
KDM3Bdown-regulatesENSG00000136574repressesR-391.254126Pr-124
MAXup-regulatesENSG00000136574repressesR-391.254126Pr-124
t(11;14)down-regulatesENSG00000136574repressesR-391.254126Pr-124
RNASeq_FGFR3_Callup-regulatesENSG00000136574repressesR-391.254126Pr-124
t(4;14)up-regulatesENSG00000136574repressesR-391.254126Pr-124
t(11;14)_cytogeneticdown-regulatesENSG00000136574repressesR-391.254126Pr-124
t(4;14)_cytogeneticup-regulatesENSG00000136574repressesR-391.254126Pr-124
AHNAK2down-regulatesIRF1activatesR-199-1.6461112Pr-124
BAI3down-regulatesIRF1activatesR-199-1.6461112Pr-124
FGFR3up-regulatesIRF1activatesR-199-1.6461112Pr-124
t(11;14)up-regulatesIRF1activatesR-199-1.6461112Pr-124
RNASeq_FGFR3_Callup-regulatesIRF1activatesR-199-1.6461112Pr-124
TRAF3down-regulatesIRF1activatesR-199-1.6461112Pr-124
DSTdown-regulatesZBTB16activatesR-5932.416686Pr-124
IRF4up-regulatesZBTB16activatesR-5932.416686Pr-124
t(11;14)up-regulatesZBTB16activatesR-5932.416686Pr-124
TRAF3down-regulatesZBTB16activatesR-5932.416686Pr-124
t(11;14)_cytogeneticup-regulatesZBTB16activatesR-5932.416686Pr-124

Regulons in program Pr-124

Regulon Cox Hazard Ratio # genes # causal flows
R-14000.106473294
R-14250.273367333
R-19620.33001151
R-18280.348637233
R-9910.573701135
R-10830.674001257
R-15770.685997183
R-720.691442374
R-21580.702295197
R-30690.785822228
R-28140.84763173
R-11490.851839268
R-16310.89544581
R-1820.9093453012
R-13400.91304186
R-30341.06768199
R-3139-1.09586112
R-391.2541267
R-199-1.64611126
R-5932.4166865

Genes in program Pr-124

EnsEMBL IdEntrez IdPreferred
ENSG00000176182 339344MYPOP
ENSG00000178028 55929DMAP1
ENSG00000178726
ENSG00000179094 5187PER1
ENSG00000182326 716C1S
ENSG00000184014 23258DENND5A
ENSG00000184205 64061TSPYL2
ENSG00000184292
ENSG00000184445 9735KNTC1
ENSG00000185332 284186TMEM105
ENSG00000186001 84859LRCH3
ENSG00000186130 10773ZBTB6
ENSG00000186710 387885CFAP73
ENSG00000186818 11006LILRB4
ENSG00000186891 8784TNFRSF18
ENSG00000189067 9516LITAF
ENSG00000196159
ENSG00000197497 79788ZNF665
ENSG00000205339 10527IPO7
ENSG00000272333 9757KMT2B

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions