Program

Causal Mechanistic Flows with regulons in program Pr-8

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)up-regulatesELF1activatesR-29940.4868076Pr-8
t(11;14)_cytogeneticup-regulatesELF1activatesR-29940.4868076Pr-8
DNAH10up-regulatesENSG00000162367activatesR-17110.57662611Pr-8
LRP2down-regulatesENSG00000162367activatesR-17110.57662611Pr-8
NEBdown-regulatesENSG00000162367activatesR-17110.57662611Pr-8
t(11;14)up-regulatesENSG00000162367activatesR-17110.57662611Pr-8
t(4;14)down-regulatesENSG00000162367activatesR-17110.57662611Pr-8
SYNE1down-regulatesENSG00000162367activatesR-17110.57662611Pr-8
del1pup-regulatesENSG00000162367activatesR-17110.57662611Pr-8
t(14;16)_cytogeneticdown-regulatesENSG00000162367activatesR-17110.57662611Pr-8
MAGI1down-regulatesCEBPGactivatesR-4490.6345217Pr-8
MYO10down-regulatesCEBPGactivatesR-4490.6345217Pr-8
NEBdown-regulatesCEBPGactivatesR-4490.6345217Pr-8
PTPRDdown-regulatesCEBPGactivatesR-4490.6345217Pr-8
SYNE1down-regulatesCEBPGactivatesR-4490.6345217Pr-8
amp1qup-regulatesCEBPGactivatesR-4490.6345217Pr-8
del13up-regulatesCEBPGactivatesR-4490.6345217Pr-8
amp1qup-regulatesZEB1activatesR-22480.91206810Pr-8
del13up-regulatesZEB1activatesR-22480.91206810Pr-8
del1pup-regulatesZEB1activatesR-22480.91206810Pr-8
COL6A5down-regulatesENSG00000245848activatesR-16490.99126713Pr-8
KIAA1244down-regulatesENSG00000245848activatesR-16490.99126713Pr-8
LRP1Bdown-regulatesENSG00000245848activatesR-16490.99126713Pr-8
LRP2down-regulatesENSG00000245848activatesR-16490.99126713Pr-8
MAGI1down-regulatesENSG00000245848activatesR-16490.99126713Pr-8
NEBdown-regulatesENSG00000245848activatesR-16490.99126713Pr-8
PTPRDdown-regulatesENSG00000245848activatesR-16490.99126713Pr-8
t(11;14)up-regulatesENSG00000245848activatesR-16490.99126713Pr-8
ZANdown-regulatesENSG00000245848activatesR-16490.99126713Pr-8
del17down-regulatesENSG00000245848activatesR-16490.99126713Pr-8
t(14;16)_cytogeneticdown-regulatesENSG00000245848activatesR-16490.99126713Pr-8
DIS3up-regulatesRFX3activatesR-16581.3380915Pr-8
FGFR3up-regulatesRFX3activatesR-16581.3380915Pr-8
NEBdown-regulatesRFX3activatesR-16581.3380915Pr-8
PRKD2up-regulatesRFX3activatesR-16581.3380915Pr-8
t(11;14)up-regulatesRFX3activatesR-16581.3380915Pr-8
RNASeq_FGFR3_Callup-regulatesRFX3activatesR-16581.3380915Pr-8
t(4;14)up-regulatesRFX3activatesR-16581.3380915Pr-8
t(4;14)_cytogeneticup-regulatesRFX3activatesR-16581.3380915Pr-8
PRDM1up-regulatesZNF350activatesR-30281.792926Pr-8
t(11;14)up-regulatesZNF350activatesR-30281.792926Pr-8
t(14;16)up-regulatesZNF350activatesR-30281.792926Pr-8
amp1qup-regulatesZNF350activatesR-30281.792926Pr-8
del1pup-regulatesZNF350activatesR-30281.792926Pr-8
t(11;14)_cytogeneticup-regulatesZNF350activatesR-30281.792926Pr-8
NEBdown-regulatesZNF281activatesR-24892.062589Pr-8
SYNE1down-regulatesZNF281activatesR-24892.062589Pr-8
t(11;14)up-regulatesFOXJ2activatesR-14332.0798627Pr-8
t(14;16)up-regulatesFOXJ2activatesR-14332.0798627Pr-8
t(4;14)up-regulatesFOXJ2activatesR-14332.0798627Pr-8
TACC2down-regulatesFOXJ2activatesR-14332.0798627Pr-8
amp1qup-regulatesFOXJ2activatesR-14332.0798627Pr-8
del13up-regulatesFOXJ2activatesR-14332.0798627Pr-8
BRAFup-regulatesATF4activatesR-942.117248Pr-8
DIS3up-regulatesATF4activatesR-942.117248Pr-8
RNASeq_FGFR3_Callup-regulatesATF4activatesR-942.117248Pr-8
t(14;16)up-regulatesATF4activatesR-942.117248Pr-8
t(4;14)up-regulatesATF4activatesR-942.117248Pr-8
amp1qup-regulatesATF4activatesR-942.117248Pr-8
del13up-regulatesATF4activatesR-942.117248Pr-8
del17down-regulatesATF4activatesR-942.117248Pr-8
t(4;14)_cytogeneticup-regulatesATF4activatesR-942.117248Pr-8
NEBup-regulatesZSCAN16repressesR-6322.37576Pr-8
PTPRDup-regulatesZSCAN16repressesR-6322.37576Pr-8
SYNE1up-regulatesZSCAN16repressesR-6322.37576Pr-8
del17up-regulatesZSCAN16repressesR-6322.37576Pr-8
NEBdown-regulatesEWSR1activatesR-25482.4146418Pr-8
t(11;14)up-regulatesEWSR1activatesR-25482.4146418Pr-8
RNASeq_FGFR3_Callup-regulatesEWSR1activatesR-25482.4146418Pr-8
t(14;16)up-regulatesEWSR1activatesR-25482.4146418Pr-8
t(4;14)up-regulatesEWSR1activatesR-25482.4146418Pr-8
SYNE1down-regulatesEWSR1activatesR-25482.4146418Pr-8
amp1qup-regulatesEWSR1activatesR-25482.4146418Pr-8
del13up-regulatesEWSR1activatesR-25482.4146418Pr-8
FAM46Cup-regulatesMZF1repressesR-30202.5703411Pr-8
FGFR3down-regulatesMZF1repressesR-30202.5703411Pr-8
IRF4down-regulatesMZF1repressesR-30202.5703411Pr-8
KIAA1244up-regulatesMZF1repressesR-30202.5703411Pr-8
t(11;14)down-regulatesMZF1repressesR-30202.5703411Pr-8
RNASeq_FGFR3_Calldown-regulatesMZF1repressesR-30202.5703411Pr-8
t(4;14)down-regulatesMZF1repressesR-30202.5703411Pr-8
t(11;14)_cytogeneticdown-regulatesMZF1repressesR-30202.5703411Pr-8
t(4;14)_cytogeneticdown-regulatesMZF1repressesR-30202.5703411Pr-8
del1pdown-regulatesZNF691repressesR-30062.602929Pr-8
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-20512.9001636Pr-8
t(14;16)down-regulatesTCF3repressesR-20512.9001636Pr-8
COL6A5down-regulatesENSG00000102678activatesR-2333.064386Pr-8
DIS3up-regulatesENSG00000102678activatesR-2333.064386Pr-8
FGFR3up-regulatesENSG00000102678activatesR-2333.064386Pr-8
PRKD2up-regulatesENSG00000102678activatesR-2333.064386Pr-8
RNASeq_FGFR3_Callup-regulatesENSG00000102678activatesR-2333.064386Pr-8
t(4;14)up-regulatesENSG00000102678activatesR-2333.064386Pr-8
amp1qup-regulatesENSG00000102678activatesR-2333.064386Pr-8
del13up-regulatesENSG00000102678activatesR-2333.064386Pr-8
t(4;14)_cytogeneticup-regulatesENSG00000102678activatesR-2333.064386Pr-8
BRAFup-regulatesHSF2activatesR-31603.0914714Pr-8
t(11;14)up-regulatesHSF2activatesR-31603.0914714Pr-8
RNASeq_FGFR3_Callup-regulatesHSF2activatesR-31603.0914714Pr-8
amp1qup-regulatesHSF2activatesR-31603.0914714Pr-8
del13up-regulatesHSF2activatesR-31603.0914714Pr-8
t(11;14)_cytogeneticup-regulatesHSF2activatesR-31603.0914714Pr-8
DIS3up-regulatesSPIBactivatesR-6653.1183720Pr-8
DNAH10up-regulatesSPIBactivatesR-6653.1183720Pr-8
RNASeq_FGFR3_Callup-regulatesSPIBactivatesR-6653.1183720Pr-8
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6653.1183720Pr-8
t(14;16)up-regulatesSPIBactivatesR-6653.1183720Pr-8
t(4;14)up-regulatesSPIBactivatesR-6653.1183720Pr-8
amp1qup-regulatesSPIBactivatesR-6653.1183720Pr-8
del13up-regulatesSPIBactivatesR-6653.1183720Pr-8
del1pup-regulatesSPIBactivatesR-6653.1183720Pr-8
t(4;14)_cytogeneticup-regulatesSPIBactivatesR-6653.1183720Pr-8
FGFR3up-regulatesIRF1activatesR-1813.2184331Pr-8
KIAA1244down-regulatesIRF1activatesR-1813.2184331Pr-8
t(11;14)up-regulatesIRF1activatesR-1813.2184331Pr-8
RNASeq_FGFR3_Callup-regulatesIRF1activatesR-1813.2184331Pr-8
t(14;16)up-regulatesIRF1activatesR-1813.2184331Pr-8
TRAF3down-regulatesIRF1activatesR-1813.2184331Pr-8
del1pup-regulatesIRF1activatesR-1813.2184331Pr-8
t(11;14)_cytogeneticup-regulatesIRF1activatesR-1813.2184331Pr-8
NEBdown-regulatesPOU2F1activatesR-753.256233Pr-8
t(11;14)up-regulatesPOU2F1activatesR-753.256233Pr-8
amp1qup-regulatesPOU2F1activatesR-753.256233Pr-8
del13up-regulatesPOU2F1activatesR-753.256233Pr-8
t(11;14)_cytogeneticup-regulatesPOU2F1activatesR-753.256233Pr-8
LRP1Bdown-regulatesIRF8activatesR-26333.2966717Pr-8
t(11;14)up-regulatesIRF8activatesR-26333.2966717Pr-8
TRAF3down-regulatesIRF8activatesR-26333.2966717Pr-8
BRAFup-regulatesZNF219activatesR-22103.353213Pr-8
CACNA1Hdown-regulatesZNF219activatesR-22103.353213Pr-8
COL6A5down-regulatesZNF219activatesR-22103.353213Pr-8
DIS3up-regulatesZNF219activatesR-22103.353213Pr-8
DSCAML1down-regulatesZNF219activatesR-22103.353213Pr-8
FGFR3up-regulatesZNF219activatesR-22103.353213Pr-8
MAXup-regulatesZNF219activatesR-22103.353213Pr-8
MYO10down-regulatesZNF219activatesR-22103.353213Pr-8
PRKD2up-regulatesZNF219activatesR-22103.353213Pr-8
RNASeq_FGFR3_Callup-regulatesZNF219activatesR-22103.353213Pr-8
t(4;14)up-regulatesZNF219activatesR-22103.353213Pr-8
t(4;14)_cytogeneticup-regulatesZNF219activatesR-22103.353213Pr-8
t(11;14)up-regulatesEP300activatesR-24343.407156Pr-8
COL6A5down-regulatesENSG00000179348activatesR-10604.1153212Pr-8
NEBdown-regulatesENSG00000179348activatesR-10604.1153212Pr-8
SYNE1down-regulatesENSG00000179348activatesR-10604.1153212Pr-8
TRAF3down-regulatesENSG00000179348activatesR-10604.1153212Pr-8
del17down-regulatesENSG00000179348activatesR-10604.1153212Pr-8
del1pup-regulatesENSG00000179348activatesR-10604.1153212Pr-8
t(14;16)_cytogeneticdown-regulatesENSG00000179348activatesR-10604.1153212Pr-8
COL6A5down-regulatesENSG00000102678activatesR-2304.322727Pr-8
DIS3up-regulatesENSG00000102678activatesR-2304.322727Pr-8
FGFR3up-regulatesENSG00000102678activatesR-2304.322727Pr-8
RNASeq_FGFR3_Callup-regulatesENSG00000102678activatesR-2304.322727Pr-8
t(4;14)up-regulatesENSG00000102678activatesR-2304.322727Pr-8
amp1qup-regulatesENSG00000102678activatesR-2304.322727Pr-8
t(4;14)_cytogeneticup-regulatesENSG00000102678activatesR-2304.322727Pr-8

Regulons in program Pr-8

Regulon Cox Hazard Ratio # genes # causal flows
R-29940.48680762
R-17110.576626118
R-4490.63452177
R-22480.912068103
R-16490.9912671311
R-16581.33809158
R-30281.7929266
R-24892.0625892
R-14332.07986276
R-942.1172489
R-6322.375764
R-25482.41464188
R-30202.57034119
R-30062.6029291
R-20512.90016362
R-2333.0643869
R-31603.09147146
R-6653.118372010
R-1813.21843318
R-753.2562335
R-26333.29667173
R-22103.35321312
R-24343.4071561
R-10604.11532127
R-2304.3227277

Genes in program Pr-8

EnsEMBL IdEntrez IdPreferred
ENSG00000181104 2149F2R
ENSG00000182446 55666NPLOC4
ENSG00000183513 493753COA5
ENSG00000186889 200728TMEM17
ENSG00000188095 145873MESP2
ENSG00000198246 55315SLC29A3
ENSG00000214078 8904CPNE1
ENSG00000239306 10432RBM14
ENSG00000239900 158ADSL
ENSG00000242689 1270CNTF
ENSG00000259494 26589MRPL46
ENSG00000271303 140809SRXN1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions