Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

MYB - MYB proto-oncogene, transcription factor

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4602 ENSG00000118513 MYB Q708E9

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: MYB

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2MYBactivatesR-6150.668149Pr-85
ATMMYBactivatesR-6150.668149Pr-85
CSMD1MYBactivatesR-6150.668149Pr-85
DMDMYBactivatesR-6150.668149Pr-85
FAM46CMYBactivatesR-6150.668149Pr-85
KRASMYBactivatesR-6150.668149Pr-85
NRASMYBactivatesR-6150.668149Pr-85
PTPRDMYBactivatesR-6150.668149Pr-85
RNASeq_MAFA_CallMYBactivatesR-6150.668149Pr-85
RNASeq_MAFB_CallMYBactivatesR-6150.668149Pr-85
t(14;16)MYBactivatesR-6150.668149Pr-85
t(4;14)MYBactivatesR-6150.668149Pr-85
ROBO2MYBactivatesR-6150.668149Pr-85
SYNE2MYBactivatesR-6150.668149Pr-85
TRIOMYBactivatesR-6150.668149Pr-85
amp1qMYBactivatesR-6150.668149Pr-85
del13MYBactivatesR-6150.668149Pr-85
del1pMYBactivatesR-6150.668149Pr-85
t(14;16)_cytogeneticMYBactivatesR-6150.668149Pr-85
AHNAK2MYBrepressesR-619-0.781425Pr-59
MACF1MYBrepressesR-619-0.781425Pr-59
NRASMYBrepressesR-619-0.781425Pr-59
t(14;16)MYBrepressesR-619-0.781425Pr-59
t(4;14)MYBrepressesR-619-0.781425Pr-59
amp1qMYBrepressesR-619-0.781425Pr-59
del13MYBrepressesR-619-0.781425Pr-59
t(14;16)_cytogeneticMYBrepressesR-619-0.781425Pr-59
ATMMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

DMDMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

FAM46CMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

KRASMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

NRASMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

PTPRDMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)MYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_MAFA_CallMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_MAFB_CallMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(14;16)MYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

SYNE2MYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)_cytogeneticMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(14;16)_cytogeneticMYBrepressesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ATMMYBactivatesR-6171.6152Pr-87
CSMD1MYBactivatesR-6171.6152Pr-87
DIS3MYBactivatesR-6171.6152Pr-87
DMDMYBactivatesR-6171.6152Pr-87
FAM46CMYBactivatesR-6171.6152Pr-87
IRF4MYBactivatesR-6171.6152Pr-87
KRASMYBactivatesR-6171.6152Pr-87
MACF1MYBactivatesR-6171.6152Pr-87
NRASMYBactivatesR-6171.6152Pr-87
t(11;14)MYBactivatesR-6171.6152Pr-87
RNASeq_MAFA_CallMYBactivatesR-6171.6152Pr-87
RNASeq_MAFB_CallMYBactivatesR-6171.6152Pr-87
t(14;16)MYBactivatesR-6171.6152Pr-87
TRIOMYBactivatesR-6171.6152Pr-87
amp1qMYBactivatesR-6171.6152Pr-87
del13MYBactivatesR-6171.6152Pr-87
del1pMYBactivatesR-6171.6152Pr-87
t(11;14)_cytogeneticMYBactivatesR-6171.6152Pr-87
t(14;16)_cytogeneticMYBactivatesR-6171.6152Pr-87
ATMMYBactivatesR-6231.65419Pr-96
DMDMYBactivatesR-6231.65419Pr-96
FAM46CMYBactivatesR-6231.65419Pr-96
MACF1MYBactivatesR-6231.65419Pr-96
NRASMYBactivatesR-6231.65419Pr-96
RNASeq_MAFA_CallMYBactivatesR-6231.65419Pr-96
RNASeq_MAFB_CallMYBactivatesR-6231.65419Pr-96
t(14;16)MYBactivatesR-6231.65419Pr-96
SYNE2MYBactivatesR-6231.65419Pr-96
TP53MYBactivatesR-6231.65419Pr-96
amp1qMYBactivatesR-6231.65419Pr-96
del13MYBactivatesR-6231.65419Pr-96
del1pMYBactivatesR-6231.65419Pr-96
t(14;16)_cytogeneticMYBactivatesR-6231.65419Pr-96
ATMMYBactivatesR-622-1.933Pr-85
CSMD1MYBactivatesR-622-1.933Pr-85
KRASMYBactivatesR-622-1.933Pr-85
NRASMYBactivatesR-622-1.933Pr-85
PTPRDMYBactivatesR-622-1.933Pr-85
RNASeq_MAFA_CallMYBactivatesR-622-1.933Pr-85
RNASeq_MAFB_CallMYBactivatesR-622-1.933Pr-85
t(14;16)MYBactivatesR-622-1.933Pr-85
TRIOMYBactivatesR-622-1.933Pr-85
amp1qMYBactivatesR-622-1.933Pr-85
del13MYBactivatesR-622-1.933Pr-85
t(14;16)_cytogeneticMYBactivatesR-622-1.933Pr-85
DIS3MYBactivatesR-6163.1672Pr-123
IRF4MYBactivatesR-6163.1672Pr-123
t(11;14)MYBactivatesR-6163.1672Pr-123
RNASeq_FGFR3_CallMYBactivatesR-6163.1672Pr-123
t(4;14)MYBactivatesR-6163.1672Pr-123
TP53MYBactivatesR-6163.1672Pr-123
amp1qMYBactivatesR-6163.1672Pr-123
t(11;14)_cytogeneticMYBactivatesR-6163.1672Pr-123
t(4;14)_cytogeneticMYBactivatesR-6163.1672Pr-123
AHNAK2MYBrepressesR-620-3.37541Pr-38
ATMMYBrepressesR-620-3.37541Pr-38
DIS3MYBrepressesR-620-3.37541Pr-38
FAM46CMYBrepressesR-620-3.37541Pr-38
FLGMYBrepressesR-620-3.37541Pr-38
IRF4MYBrepressesR-620-3.37541Pr-38
MACF1MYBrepressesR-620-3.37541Pr-38
NRASMYBrepressesR-620-3.37541Pr-38
PTPRDMYBrepressesR-620-3.37541Pr-38
t(11;14)MYBrepressesR-620-3.37541Pr-38
RNASeq_FGFR3_CallMYBrepressesR-620-3.37541Pr-38
RNASeq_MAFA_CallMYBrepressesR-620-3.37541Pr-38
RNASeq_MAFB_CallMYBrepressesR-620-3.37541Pr-38
t(14;16)MYBrepressesR-620-3.37541Pr-38
t(4;14)MYBrepressesR-620-3.37541Pr-38
ROBO2MYBrepressesR-620-3.37541Pr-38
TRIOMYBrepressesR-620-3.37541Pr-38
amp1qMYBrepressesR-620-3.37541Pr-38
del13MYBrepressesR-620-3.37541Pr-38
t(14;16)_cytogeneticMYBrepressesR-620-3.37541Pr-38
t(4;14)_cytogeneticMYBrepressesR-620-3.37541Pr-38
MACF1MYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

RNASeq_MAFA_CallMYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

RNASeq_MAFB_CallMYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

t(14;16)MYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

ROBO2MYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

SYNE2MYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

TP53MYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

del1pMYBactivatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

DIS3MYBrepressesR-626-4.24578Pr-36
FAM46CMYBrepressesR-626-4.24578Pr-36
IRF4MYBrepressesR-626-4.24578Pr-36
NRASMYBrepressesR-626-4.24578Pr-36
t(11;14)MYBrepressesR-626-4.24578Pr-36
RNASeq_FGFR3_CallMYBrepressesR-626-4.24578Pr-36
RNASeq_MAFB_CallMYBrepressesR-626-4.24578Pr-36
t(14;16)MYBrepressesR-626-4.24578Pr-36
t(4;14)MYBrepressesR-626-4.24578Pr-36
TRIOMYBrepressesR-626-4.24578Pr-36
amp1qMYBrepressesR-626-4.24578Pr-36
del13MYBrepressesR-626-4.24578Pr-36
t(11;14)_cytogeneticMYBrepressesR-626-4.24578Pr-36
t(4;14)_cytogeneticMYBrepressesR-626-4.24578Pr-36
IRF4MYBrepressesR-621-5.47246Pr-104
t(11;14)MYBrepressesR-621-5.47246Pr-104
RNASeq_MAFA_CallMYBrepressesR-621-5.47246Pr-104
RNASeq_MAFB_CallMYBrepressesR-621-5.47246Pr-104
t(14;16)MYBrepressesR-621-5.47246Pr-104
TP53MYBrepressesR-621-5.47246Pr-104
t(11;14)_cytogeneticMYBrepressesR-621-5.47246Pr-104
DIS3MYBactivatesR-6185.69454Pr-108
FAM46CMYBactivatesR-6185.69454Pr-108
IRF4MYBactivatesR-6185.69454Pr-108
NRASMYBactivatesR-6185.69454Pr-108
RNASeq_FGFR3_CallMYBactivatesR-6185.69454Pr-108
t(14;16)MYBactivatesR-6185.69454Pr-108
t(4;14)MYBactivatesR-6185.69454Pr-108
TP53MYBactivatesR-6185.69454Pr-108
TRIOMYBactivatesR-6185.69454Pr-108
amp1qMYBactivatesR-6185.69454Pr-108
del13MYBactivatesR-6185.69454Pr-108
del1pMYBactivatesR-6185.69454Pr-108
t(4;14)_cytogeneticMYBactivatesR-6185.69454Pr-108
AHNAK2MYBactivatesR-6148.54513Pr-68
DMDMYBactivatesR-6148.54513Pr-68
MACF1MYBactivatesR-6148.54513Pr-68
t(14;16)MYBactivatesR-6148.54513Pr-68
TP53MYBactivatesR-6148.54513Pr-68
del1pMYBactivatesR-6148.54513Pr-68
t(14;16)_cytogeneticMYBactivatesR-6148.54513Pr-68

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.