Program

Causal Mechanistic Flows with regulons in program Pr-114

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
PTPRDdown-regulatesHSF1activatesR-480.44855316Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

BAI3up-regulatesHMBOX1repressesR-2383-0.9676956Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

IRF4up-regulatesHMBOX1repressesR-2383-0.9676956Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

PKHD1L1down-regulatesHMBOX1repressesR-2383-0.9676956Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)up-regulatesHMBOX1repressesR-2383-0.9676956Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_CCND3_Callup-regulatesHMBOX1repressesR-2383-0.9676956Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)_cytogeneticup-regulatesHMBOX1repressesR-2383-0.9676956Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ATMup-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

DMDup-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

FAM46Cdown-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

KRASdown-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

NRASdown-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

PTPRDup-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)up-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_MAFA_Callup-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_MAFB_Callup-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(14;16)up-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

SYNE2up-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)_cytogeneticup-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(14;16)_cytogeneticup-regulatesMYBrepressesR-6241.059146Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

DIS3up-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

FGFR3up-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

NRASdown-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

PRKD2up-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_FGFR3_Callup-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)up-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

del13up-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)_cytogeneticup-regulatesENSG00000102678activatesR-2312.541046Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

DSTdown-regulatesIRF7activatesR-10873.3554315Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ROBO1down-regulatesIRF7activatesR-10873.3554315Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

TP53up-regulatesIRF7activatesR-10873.3554315Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

TRAF3down-regulatesIRF7activatesR-10873.3554315Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

amp1qdown-regulatesIRF7activatesR-10873.3554315Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

BAI3down-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

DNAH10up-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

DSTdown-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

FGFR3up-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_CCND2_Calldown-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_FGFR3_Callup-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)up-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

SVILdown-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

TRAF3down-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)_cytogeneticup-regulatesSTAT4activatesR-26534.5415711Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

FGFR3up-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(11;14)down-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_FGFR3_Callup-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_MAFA_Callup-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(14;16)up-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

MYCdown-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)up-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

SYNE2up-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

del13up-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)_cytogeneticup-regulatesMAFactivatesR-1075.094878Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

Regulons in program Pr-114

Regulon Cox Hazard Ratio # genes # causal flows
R-480.448553161
R-2383-0.96769566
R-6241.05914613
R-2312.5410468
R-10873.35543155
R-26534.541571110
R-1075.09487810

Genes in program Pr-114

EnsEMBL IdEntrez IdPreferred
ENSG00000180628 84333PCGF5
ENSG00000187634 148398SAMD11
ENSG00000188997 283219KCTD21

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions