Program

Causal Mechanistic Flows with regulons in program Pr-68

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)down-regulatesKLF7repressesR-2837.0725310Pr-68
TP53down-regulatesKLF7repressesR-2837.0725310Pr-68
ZNF462down-regulatesKLF7repressesR-2837.0725310Pr-68
t(11;14)_cytogeneticdown-regulatesKLF7repressesR-2837.0725310Pr-68
MACF1up-regulatesZNF143activatesR-23197.332497Pr-68
MXRA5up-regulatesZNF143activatesR-23197.332497Pr-68
MYCup-regulatesZNF143activatesR-23197.332497Pr-68
SYNE1up-regulatesZNF143activatesR-23197.332497Pr-68
t(14;16)_cytogeneticup-regulatesZNF143activatesR-23197.332497Pr-68
MYCdown-regulatesARID5BrepressesR-10967.7132619Pr-68
TP53down-regulatesARID5BrepressesR-10967.7132619Pr-68
MXRA5down-regulatesPOU2F2repressesR-25188.015456Pr-68
RNASeq_MAFA_Calldown-regulatesPOU2F2repressesR-25188.015456Pr-68
RNASeq_MAFB_Calldown-regulatesPOU2F2repressesR-25188.015456Pr-68
t(14;16)down-regulatesPOU2F2repressesR-25188.015456Pr-68
TP53down-regulatesPOU2F2repressesR-25188.015456Pr-68
AHNAK2up-regulatesPARP1activatesR-26368.1283812Pr-68
DCHS1up-regulatesPARP1activatesR-26368.1283812Pr-68
DNAH5up-regulatesPARP1activatesR-26368.1283812Pr-68
FAT3up-regulatesPARP1activatesR-26368.1283812Pr-68
MACF1up-regulatesPARP1activatesR-26368.1283812Pr-68
MAXup-regulatesPARP1activatesR-26368.1283812Pr-68
MUC12up-regulatesPARP1activatesR-26368.1283812Pr-68
PTPRDup-regulatesPARP1activatesR-26368.1283812Pr-68
RELNup-regulatesPARP1activatesR-26368.1283812Pr-68
RNASeq_FGFR3_Callup-regulatesPARP1activatesR-26368.1283812Pr-68
RNASeq_MAFB_Callup-regulatesPARP1activatesR-26368.1283812Pr-68
t(4;14)up-regulatesPARP1activatesR-26368.1283812Pr-68
TTNup-regulatesPARP1activatesR-26368.1283812Pr-68
XIRP2up-regulatesPARP1activatesR-26368.1283812Pr-68
ZNF462up-regulatesPARP1activatesR-26368.1283812Pr-68
t(14;16)_cytogeneticup-regulatesPARP1activatesR-26368.1283812Pr-68
TACC2down-regulatesZNF410repressesR-19318.2991716Pr-68
ZNF208up-regulatesTCF3activatesR-20438.36323138Pr-68
AHNAK2down-regulatesFOXO1repressesR-13938.37511107Pr-68
FAT3down-regulatesFOXO1repressesR-13938.37511107Pr-68
MACF1down-regulatesFOXO1repressesR-13938.37511107Pr-68
TACC2down-regulatesFOXO1repressesR-13938.37511107Pr-68
t(14;16)_cytogeneticdown-regulatesFOXO1repressesR-13938.37511107Pr-68
MAXup-regulatesTCF3activatesR-20468.4728750Pr-68
ZNF208up-regulatesTCF3activatesR-20468.4728750Pr-68
t(14;16)up-regulatesELK1activatesR-6358.477754Pr-68
del1pup-regulatesELK1activatesR-6358.477754Pr-68
AHNAK2up-regulatesMYBactivatesR-6148.5451343Pr-68
DMDup-regulatesMYBactivatesR-6148.5451343Pr-68
MACF1up-regulatesMYBactivatesR-6148.5451343Pr-68
t(14;16)up-regulatesMYBactivatesR-6148.5451343Pr-68
TP53up-regulatesMYBactivatesR-6148.5451343Pr-68
del1pup-regulatesMYBactivatesR-6148.5451343Pr-68
t(14;16)_cytogeneticup-regulatesMYBactivatesR-6148.5451343Pr-68
AHNAK2up-regulatesE2F2activatesR-29428.5990619Pr-68
CMYA5up-regulatesE2F2activatesR-29428.5990619Pr-68
DMDup-regulatesE2F2activatesR-29428.5990619Pr-68
DNAH10up-regulatesE2F2activatesR-29428.5990619Pr-68
DNAH5up-regulatesE2F2activatesR-29428.5990619Pr-68
FAT3up-regulatesE2F2activatesR-29428.5990619Pr-68
MACF1up-regulatesE2F2activatesR-29428.5990619Pr-68
MAXup-regulatesE2F2activatesR-29428.5990619Pr-68
t(14;16)up-regulatesE2F2activatesR-29428.5990619Pr-68
MYCup-regulatesE2F2activatesR-29428.5990619Pr-68
SYNE1up-regulatesE2F2activatesR-29428.5990619Pr-68
TP53up-regulatesE2F2activatesR-29428.5990619Pr-68
TTNup-regulatesE2F2activatesR-29428.5990619Pr-68
ZNF208up-regulatesE2F2activatesR-29428.5990619Pr-68
ZNF462up-regulatesE2F2activatesR-29428.5990619Pr-68
del17up-regulatesE2F2activatesR-29428.5990619Pr-68
del17pup-regulatesE2F2activatesR-29428.5990619Pr-68
t(14;16)_cytogeneticup-regulatesE2F2activatesR-29428.5990619Pr-68
AHNAK2up-regulatesE2F8activatesR-16268.6249333Pr-68
CMYA5up-regulatesE2F8activatesR-16268.6249333Pr-68
DMDup-regulatesE2F8activatesR-16268.6249333Pr-68
DNAH10up-regulatesE2F8activatesR-16268.6249333Pr-68
DNAH5up-regulatesE2F8activatesR-16268.6249333Pr-68
FAT3up-regulatesE2F8activatesR-16268.6249333Pr-68
HIST1H1Edown-regulatesE2F8activatesR-16268.6249333Pr-68
MACF1up-regulatesE2F8activatesR-16268.6249333Pr-68
MAXup-regulatesE2F8activatesR-16268.6249333Pr-68
MXRA5up-regulatesE2F8activatesR-16268.6249333Pr-68
PCDH15down-regulatesE2F8activatesR-16268.6249333Pr-68
PKHD1L1up-regulatesE2F8activatesR-16268.6249333Pr-68
t(11;14)up-regulatesE2F8activatesR-16268.6249333Pr-68
t(14;16)up-regulatesE2F8activatesR-16268.6249333Pr-68
MYCup-regulatesE2F8activatesR-16268.6249333Pr-68
TP53up-regulatesE2F8activatesR-16268.6249333Pr-68
TTNup-regulatesE2F8activatesR-16268.6249333Pr-68
ZNF208up-regulatesE2F8activatesR-16268.6249333Pr-68
ZNF462up-regulatesE2F8activatesR-16268.6249333Pr-68
del17up-regulatesE2F8activatesR-16268.6249333Pr-68
del17pup-regulatesE2F8activatesR-16268.6249333Pr-68
del1pup-regulatesE2F8activatesR-16268.6249333Pr-68
t(14;16)_cytogeneticup-regulatesE2F8activatesR-16268.6249333Pr-68
MAXup-regulatesE2F7activatesR-13848.6378837Pr-68
t(11;14)up-regulatesE2F7activatesR-13848.6378837Pr-68
AHNAK2up-regulatesE2F1activatesR-21738.7648619Pr-68
CMYA5up-regulatesE2F1activatesR-21738.7648619Pr-68
DMDup-regulatesE2F1activatesR-21738.7648619Pr-68
DNAH5up-regulatesE2F1activatesR-21738.7648619Pr-68
FAT3up-regulatesE2F1activatesR-21738.7648619Pr-68
MACF1up-regulatesE2F1activatesR-21738.7648619Pr-68
MAXup-regulatesE2F1activatesR-21738.7648619Pr-68
MXRA5up-regulatesE2F1activatesR-21738.7648619Pr-68
t(11;14)up-regulatesE2F1activatesR-21738.7648619Pr-68
t(14;16)up-regulatesE2F1activatesR-21738.7648619Pr-68
MYCup-regulatesE2F1activatesR-21738.7648619Pr-68
TP53up-regulatesE2F1activatesR-21738.7648619Pr-68
TTNup-regulatesE2F1activatesR-21738.7648619Pr-68
ZNF208up-regulatesE2F1activatesR-21738.7648619Pr-68
ZNF462up-regulatesE2F1activatesR-21738.7648619Pr-68
del17up-regulatesE2F1activatesR-21738.7648619Pr-68
del17pup-regulatesE2F1activatesR-21738.7648619Pr-68
del1pup-regulatesE2F1activatesR-21738.7648619Pr-68
t(14;16)_cytogeneticup-regulatesE2F1activatesR-21738.7648619Pr-68
AHNAK2up-regulatesE2F1activatesR-21728.8292152Pr-68
CMYA5up-regulatesE2F1activatesR-21728.8292152Pr-68
DMDup-regulatesE2F1activatesR-21728.8292152Pr-68
DNAH5up-regulatesE2F1activatesR-21728.8292152Pr-68
FAT3up-regulatesE2F1activatesR-21728.8292152Pr-68
MACF1up-regulatesE2F1activatesR-21728.8292152Pr-68
MAXup-regulatesE2F1activatesR-21728.8292152Pr-68
MXRA5up-regulatesE2F1activatesR-21728.8292152Pr-68
PKHD1L1up-regulatesE2F1activatesR-21728.8292152Pr-68
t(11;14)up-regulatesE2F1activatesR-21728.8292152Pr-68
t(14;16)up-regulatesE2F1activatesR-21728.8292152Pr-68
MYCup-regulatesE2F1activatesR-21728.8292152Pr-68
TP53up-regulatesE2F1activatesR-21728.8292152Pr-68
TTNup-regulatesE2F1activatesR-21728.8292152Pr-68
ZNF208up-regulatesE2F1activatesR-21728.8292152Pr-68
ZNF462up-regulatesE2F1activatesR-21728.8292152Pr-68
del17up-regulatesE2F1activatesR-21728.8292152Pr-68
del17pup-regulatesE2F1activatesR-21728.8292152Pr-68
del1pup-regulatesE2F1activatesR-21728.8292152Pr-68
t(14;16)_cytogeneticup-regulatesE2F1activatesR-21728.8292152Pr-68
AHNAK2up-regulatesE2F2activatesR-29448.9061510Pr-68
CMYA5up-regulatesE2F2activatesR-29448.9061510Pr-68
DCHS1up-regulatesE2F2activatesR-29448.9061510Pr-68
DIS3up-regulatesE2F2activatesR-29448.9061510Pr-68
DMDup-regulatesE2F2activatesR-29448.9061510Pr-68
DNAH10up-regulatesE2F2activatesR-29448.9061510Pr-68
DNAH5up-regulatesE2F2activatesR-29448.9061510Pr-68
FAM46Cdown-regulatesE2F2activatesR-29448.9061510Pr-68
FAT3up-regulatesE2F2activatesR-29448.9061510Pr-68
MACF1up-regulatesE2F2activatesR-29448.9061510Pr-68
MAXup-regulatesE2F2activatesR-29448.9061510Pr-68
RELNup-regulatesE2F2activatesR-29448.9061510Pr-68
RNASeq_FGFR3_Callup-regulatesE2F2activatesR-29448.9061510Pr-68
RNASeq_MAFA_Callup-regulatesE2F2activatesR-29448.9061510Pr-68
RNASeq_MAFB_Callup-regulatesE2F2activatesR-29448.9061510Pr-68
t(14;16)up-regulatesE2F2activatesR-29448.9061510Pr-68
t(4;14)up-regulatesE2F2activatesR-29448.9061510Pr-68
SVILup-regulatesE2F2activatesR-29448.9061510Pr-68
TACC2up-regulatesE2F2activatesR-29448.9061510Pr-68
TP53up-regulatesE2F2activatesR-29448.9061510Pr-68
TTNup-regulatesE2F2activatesR-29448.9061510Pr-68
ZNF208up-regulatesE2F2activatesR-29448.9061510Pr-68
ZNF462up-regulatesE2F2activatesR-29448.9061510Pr-68
amp1qup-regulatesE2F2activatesR-29448.9061510Pr-68
del17up-regulatesE2F2activatesR-29448.9061510Pr-68
del17pup-regulatesE2F2activatesR-29448.9061510Pr-68
t(14;16)_cytogeneticup-regulatesE2F2activatesR-29448.9061510Pr-68
t(4;14)_cytogeneticup-regulatesE2F2activatesR-29448.9061510Pr-68
AHNAK2up-regulatesE2F8activatesR-16279.2640811Pr-68
CMYA5up-regulatesE2F8activatesR-16279.2640811Pr-68
DMDup-regulatesE2F8activatesR-16279.2640811Pr-68
DNAH10up-regulatesE2F8activatesR-16279.2640811Pr-68
DNAH5up-regulatesE2F8activatesR-16279.2640811Pr-68
FAT3up-regulatesE2F8activatesR-16279.2640811Pr-68
HIST1H1Edown-regulatesE2F8activatesR-16279.2640811Pr-68
MACF1up-regulatesE2F8activatesR-16279.2640811Pr-68
MAXup-regulatesE2F8activatesR-16279.2640811Pr-68
MXRA5up-regulatesE2F8activatesR-16279.2640811Pr-68
PCDH15down-regulatesE2F8activatesR-16279.2640811Pr-68
t(11;14)up-regulatesE2F8activatesR-16279.2640811Pr-68
t(14;16)up-regulatesE2F8activatesR-16279.2640811Pr-68
MYCup-regulatesE2F8activatesR-16279.2640811Pr-68
TP53up-regulatesE2F8activatesR-16279.2640811Pr-68
TTNup-regulatesE2F8activatesR-16279.2640811Pr-68
ZNF208up-regulatesE2F8activatesR-16279.2640811Pr-68
ZNF462up-regulatesE2F8activatesR-16279.2640811Pr-68
del17up-regulatesE2F8activatesR-16279.2640811Pr-68
del17pup-regulatesE2F8activatesR-16279.2640811Pr-68
del1pup-regulatesE2F8activatesR-16279.2640811Pr-68
t(14;16)_cytogeneticup-regulatesE2F8activatesR-16279.2640811Pr-68

Regulons in program Pr-68

Regulon Cox Hazard Ratio # genes # causal flows
R-2837.07253104
R-23197.3324975
R-10967.71326192
R-25188.0154565
R-26368.128381216
R-19318.29917161
R-20438.363231381
R-13938.375111075
R-20468.47287502
R-6358.4777542
R-6148.54513437
R-29428.599061918
R-16268.624933323
R-13848.63788372
R-21738.764861919
R-21728.829215220
R-29448.906151028
R-16279.264081122

Genes in program Pr-68

EnsEMBL IdEntrez IdPreferred

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions