Program

Causal Mechanistic Flows with regulons in program Pr-96

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
del13up-regulatesRARAactivatesR-1710.9748787Pr-96
CYLDup-regulatesETS1activatesR-81.38887Pr-96
MAXdown-regulatesETS1activatesR-81.38887Pr-96
NRASdown-regulatesETS1activatesR-81.38887Pr-96
RNASeq_CCND2_Calldown-regulatesETS1activatesR-81.38887Pr-96
RNASeq_MAFA_Callup-regulatesETS1activatesR-81.38887Pr-96
RNASeq_MAFB_Callup-regulatesETS1activatesR-81.38887Pr-96
t(14;16)up-regulatesETS1activatesR-81.38887Pr-96
SYNE2up-regulatesETS1activatesR-81.38887Pr-96
t(14;16)down-regulatesPAX6repressesR-1551-1.6354911Pr-96
amp1qdown-regulatesPAX6repressesR-1551-1.6354911Pr-96
del13down-regulatesPAX6repressesR-1551-1.6354911Pr-96
ATMup-regulatesMYBactivatesR-6231.654197Pr-96
DMDup-regulatesMYBactivatesR-6231.654197Pr-96
FAM46Cdown-regulatesMYBactivatesR-6231.654197Pr-96
MACF1up-regulatesMYBactivatesR-6231.654197Pr-96
NRASdown-regulatesMYBactivatesR-6231.654197Pr-96
RNASeq_MAFA_Callup-regulatesMYBactivatesR-6231.654197Pr-96
RNASeq_MAFB_Callup-regulatesMYBactivatesR-6231.654197Pr-96
t(14;16)up-regulatesMYBactivatesR-6231.654197Pr-96
SYNE2up-regulatesMYBactivatesR-6231.654197Pr-96
TP53up-regulatesMYBactivatesR-6231.654197Pr-96
amp1qup-regulatesMYBactivatesR-6231.654197Pr-96
del13up-regulatesMYBactivatesR-6231.654197Pr-96
del1pup-regulatesMYBactivatesR-6231.654197Pr-96
t(14;16)_cytogeneticup-regulatesMYBactivatesR-6231.654197Pr-96
RNASeq_FGFR3_Calldown-regulatesNFKB1activatesR-1590-1.866956Pr-96
t(4;14)down-regulatesNFKB1activatesR-1590-1.866956Pr-96
t(4;14)_cytogeneticdown-regulatesNFKB1activatesR-1590-1.866956Pr-96
t(11;14)up-regulatesELK1activatesR-6492.085838Pr-96
RNASeq_MAFA_Callup-regulatesELK1activatesR-6492.085838Pr-96
t(14;16)up-regulatesELK1activatesR-6492.085838Pr-96
amp1qup-regulatesELK1activatesR-6492.085838Pr-96
del13up-regulatesELK1activatesR-6492.085838Pr-96
ATMdown-regulatesFLI1repressesR-7932.523267Pr-96
DIS3down-regulatesFLI1repressesR-7932.523267Pr-96
DMDdown-regulatesFLI1repressesR-7932.523267Pr-96
FAM46Cup-regulatesFLI1repressesR-7932.523267Pr-96
MACF1down-regulatesFLI1repressesR-7932.523267Pr-96
NRASup-regulatesFLI1repressesR-7932.523267Pr-96
PTPRTdown-regulatesFLI1repressesR-7932.523267Pr-96
RNASeq_MAFA_Calldown-regulatesFLI1repressesR-7932.523267Pr-96
RNASeq_MAFB_Calldown-regulatesFLI1repressesR-7932.523267Pr-96
t(14;16)down-regulatesFLI1repressesR-7932.523267Pr-96
t(4;14)down-regulatesFLI1repressesR-7932.523267Pr-96
TRIOdown-regulatesFLI1repressesR-7932.523267Pr-96
TTNdown-regulatesFLI1repressesR-7932.523267Pr-96
amp1qdown-regulatesFLI1repressesR-7932.523267Pr-96
del13down-regulatesFLI1repressesR-7932.523267Pr-96
t(14;16)_cytogeneticdown-regulatesFLI1repressesR-7932.523267Pr-96

Regulons in program Pr-96

Regulon Cox Hazard Ratio # genes # causal flows
R-1710.97487871
R-81.388878
R-1551-1.63549113
R-6231.65419714
R-1590-1.8669563
R-6492.0858385
R-7932.52326716

Genes in program Pr-96

EnsEMBL IdEntrez IdPreferred
ENSG00000187764 10507SEMA4D
ENSG00000198561 1500CTNND1
ENSG00000205208 201725C4orf46
ENSG00000205413 54809SAMD9
ENSG00000215788 8718TNFRSF25
ENSG00000239998 11027LILRA2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions