Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation TTN

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
HINFPdown-regulatesR-2627-0.48712Pr-88
FLI1down-regulatesR-786-0.733394Pr-59
CEBPBdown-regulatesR-1777-0.838666Pr-129
SP1up-regulatesR-27131.08118Pr-87
CEBPBdown-regulatesR-17621.16852Pr-127
SP1up-regulatesR-27251.37906Pr-93
ZNF740down-regulatesR-3841.98118Pr-52
ENSG00000168269down-regulatesR-1570-2.10985Pr-35
ATF5down-regulatesR-2405-2.17053Pr-109
E2F1up-regulatesR-2176-2.17422Pr-61
CEBPBdown-regulatesR-1766-2.18542Pr-126
ZNF740down-regulatesR-397-2.24578Pr-139
ENSG00000168269down-regulatesR-15712.51736Pr-136
FLI1down-regulatesR-7932.52326Pr-96
ZBTB7Bup-regulatesR-12332.59774Pr-52
FLI1down-regulatesR-7952.77664Pr-50
ELK4up-regulatesR-769-3.00912Pr-102
TRIM28down-regulatesR-1506-3.3709Pr-35
CREB3L2down-regulatesR-522-3.41802Pr-102
ENSG00000168269down-regulatesR-15683.70657Pr-50
MEF2Dup-regulatesR-8703.82168Pr-52
SP1up-regulatesR-27163.88928Pr-52
MAZup-regulatesR-4964.15346Pr-52
MEF2Dup-regulatesR-8714.1859Pr-48
MAZup-regulatesR-4984.36616Pr-48
RREB1down-regulatesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SP1up-regulatesR-2720-6.02354Pr-104
SP1up-regulatesR-27196.73271Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

PARP1up-regulatesR-26368.12838Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions