Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation KDM3B

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TEAD1down-regulatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

FOXO1down-regulatesR-14150.265962Pr-33
SOX4down-regulatesR-2182-0.40215Pr-23
ENSG00000165066up-regulatesR-30830.448378Pr-99
ENSG00000135638down-regulatesR-19580.576875Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

VBP1up-regulatesR-21030.638139Pr-135
TCF4down-regulatesR-29990.734651Pr-131
RREB1down-regulatesR-2296-0.757232Pr-9
SOX4down-regulatesR-2189-0.776926Pr-12
ZFXdown-regulatesR-1916-0.823941Pr-0
PBX1down-regulatesR-2109-0.833545Pr-5
EGR1down-regulatesR-2901-0.911846Pr-20
SOX4down-regulatesR-2184-1.09056Pr-113
ZNF143up-regulatesR-2323-1.17016Pr-27
SOX4down-regulatesR-21791.18112Pr-117
PLAG1down-regulatesR-15171.22016Pr-108
ENSG00000136574down-regulatesR-391.25412Pr-124
RORAdown-regulatesR-2279-1.26921Pr-27
ZNF143up-regulatesR-2316-1.2845Pr-22
CREB3L2down-regulatesR-521-1.29128Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

HOXD1down-regulatesR-13031.32893Pr-131
POU2F2down-regulatesR-25121.37817Pr-62
FOXO1down-regulatesR-1403-1.38577Pr-12
RREB1down-regulatesR-2305-1.52832Pr-0
RREB1down-regulatesR-2291-1.6207Pr-12
RREB1down-regulatesR-2303-1.65549Pr-113
TCF4down-regulatesR-3000-1.68762Pr-105
POU2F2down-regulatesR-2517-1.83475Pr-113
HLXdown-regulatesR-2765-1.89441Pr-22
SOX4down-regulatesR-2185-1.98014Pr-0
PLAG1down-regulatesR-1525-2.09931Pr-42
RORAdown-regulatesR-2278-2.37391Pr-113
ETV2down-regulatesR-15082.5634Pr-59
KLF4down-regulatesR-2755-2.59765Pr-110
MAFGdown-regulatesR-1492-2.64388Pr-0
PLAG1down-regulatesR-15182.66482Pr-108
PLAG1down-regulatesR-15192.73334Pr-108
HOXA5down-regulatesR-25-2.84707Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

ENSG00000105991down-regulatesR-229-2.84707Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

SOX4down-regulatesR-21772.93862Pr-108
PBX1down-regulatesR-21063.00005Pr-123
POU2F2down-regulatesR-2519-3.13355Pr-104
HOXD1down-regulatesR-13013.24332Pr-108
PBX1down-regulatesR-21053.24509Pr-108
SOX4down-regulatesR-2188-3.25506Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

TEAD1down-regulatesR-12143.31075Pr-108
FOXO1down-regulatesR-1413-3.33652Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

ZFXdown-regulatesR-19293.48789Pr-117
HLXdown-regulatesR-2766-3.53397Pr-42
KLF4down-regulatesR-27593.56619Pr-74
TEAD1down-regulatesR-12163.63699Pr-108
ENSG00000136574down-regulatesR-353.65653Pr-123
PLAG1down-regulatesR-15273.7556Pr-54
TEAD1down-regulatesR-1218-3.91201Pr-112
SOX4down-regulatesR-21784.19485Pr-108
TCF4down-regulatesR-3001-4.24514Pr-110
HLXdown-regulatesR-2762-4.29241Pr-32
PLAG1down-regulatesR-1526-4.47157Pr-11
RORAdown-regulatesR-22814.95755Pr-70
POU2F2down-regulatesR-2516-5.21606Pr-38
PLAG1down-regulatesR-1523-6.09323Pr-135

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions