Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ZNF143 - zinc finger protein 143

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
7702 ENSG00000166478 ZNF143 P52747

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ZNF143

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
FAT3ZNF143repressesR-2318-0.27862Pr-4
NRASZNF143repressesR-2318-0.27862Pr-4
SYNE1ZNF143repressesR-2318-0.27862Pr-4
t(14;16)_cytogeneticZNF143repressesR-2318-0.27862Pr-4
ABCA13ZNF143repressesR-23120.42534Pr-25
MACF1ZNF143repressesR-23120.42534Pr-25
RNASeq_MAFA_CallZNF143repressesR-23120.42534Pr-25
DCHS1ZNF143repressesR-2325-0.447293Pr-3
RNASeq_MAFA_CallZNF143repressesR-2325-0.447293Pr-3
SYNE1ZNF143repressesR-2325-0.447293Pr-3
MACF1ZNF143repressesR-2309-0.580912Pr-2
RNASeq_MAFA_CallZNF143repressesR-2309-0.580912Pr-2
MYCZNF143repressesR-2309-0.580912Pr-2
SYNE1ZNF143repressesR-2309-0.580912Pr-2
ABCA13ZNF143activatesR-23141.04902Pr-99
FAT3ZNF143activatesR-23141.04902Pr-99
MYCZNF143activatesR-23141.04902Pr-99
KDM3BZNF143repressesR-2323-1.17016Pr-27
MYCZNF143repressesR-2323-1.17016Pr-27
KDM3BZNF143repressesR-2316-1.2845Pr-22
RNASeq_MAFA_CallZNF143repressesR-2316-1.2845Pr-22
FAT3ZNF143activatesR-2321-1.32991Pr-129
ANK2ZNF143repressesR-2322-1.59054Pr-3
MACF1ZNF143repressesR-2322-1.59054Pr-3
RNASeq_MAFA_CallZNF143repressesR-2322-1.59054Pr-3
MYCZNF143repressesR-2322-1.59054Pr-3
t(14;16)_cytogeneticZNF143repressesR-2322-1.59054Pr-3
SYNE1ZNF143activatesR-2317-1.66516Pr-99
EGR1ZNF143repressesR-2315-1.77492Pr-30
FAT3ZNF143repressesR-2315-1.77492Pr-30
DCHS1ZNF143activatesR-23082.93506Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

FAT3ZNF143activatesR-23082.93506Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

NRASZNF143activatesR-23082.93506Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

ROBO1ZNF143activatesR-23082.93506Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

t(14;16)_cytogeneticZNF143activatesR-23082.93506Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

ANK2ZNF143activatesR-23244.09925Pr-50
DCHS1ZNF143activatesR-23244.09925Pr-50
FAT3ZNF143activatesR-23244.09925Pr-50
NRASZNF143activatesR-23244.09925Pr-50
t(14;16)_cytogeneticZNF143activatesR-23244.09925Pr-50
HMCN1ZNF143activatesR-2311-4.58673Pr-99
MACF1ZNF143activatesR-23197.33249Pr-68
MXRA5ZNF143activatesR-23197.33249Pr-68
MYCZNF143activatesR-23197.33249Pr-68
SYNE1ZNF143activatesR-23197.33249Pr-68
t(14;16)_cytogeneticZNF143activatesR-23197.33249Pr-68

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.