Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

PAX6 - paired box 6

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
5080 ENSG00000007372 PAX6 A0A1W2PPG3

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: PAX6

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
FGFR3PAX6activatesR-15560.0296134Pr-117
IRF4PAX6activatesR-15560.0296134Pr-117
NEBPAX6activatesR-15560.0296134Pr-117
t(11;14)PAX6activatesR-15560.0296134Pr-117
RNASeq_FGFR3_CallPAX6activatesR-15560.0296134Pr-117
MYCPAX6activatesR-15560.0296134Pr-117
t(4;14)PAX6activatesR-15560.0296134Pr-117
RYR1PAX6activatesR-15560.0296134Pr-117
SYNE1PAX6activatesR-15560.0296134Pr-117
del13PAX6activatesR-15560.0296134Pr-117
t(11;14)_cytogeneticPAX6activatesR-15560.0296134Pr-117
t(4;14)_cytogeneticPAX6activatesR-15560.0296134Pr-117
DIS3PAX6repressesR-1545-0.374773Pr-14
FAM46CPAX6repressesR-1545-0.374773Pr-14
IRF4PAX6repressesR-1545-0.374773Pr-14
NEBPAX6repressesR-1545-0.374773Pr-14
t(11;14)PAX6repressesR-1545-0.374773Pr-14
t(14;16)PAX6repressesR-1545-0.374773Pr-14
MYCPAX6repressesR-1545-0.374773Pr-14
amp1qPAX6repressesR-1545-0.374773Pr-14
del13PAX6repressesR-1545-0.374773Pr-14
t(11;14)_cytogeneticPAX6repressesR-1545-0.374773Pr-14
FGFR3PAX6repressesR-1554-0.5394Pr-4
t(4;14)PAX6repressesR-1554-0.5394Pr-4
amp1qPAX6repressesR-1554-0.5394Pr-4
del13PAX6repressesR-1554-0.5394Pr-4
NEBPAX6repressesR-15430.590247Pr-1
t(14;16)PAX6repressesR-15430.590247Pr-1
amp1qPAX6repressesR-15430.590247Pr-1
del13PAX6repressesR-15430.590247Pr-1
NEBPAX6repressesR-1542-0.629177Pr-0
SYNE1PAX6repressesR-1542-0.629177Pr-0
amp1qPAX6repressesR-1542-0.629177Pr-0
del13PAX6repressesR-1542-0.629177Pr-0
FGFR3PAX6repressesR-15460.96868Pr-16
PRKD2PAX6repressesR-15460.96868Pr-16
t(11;14)PAX6repressesR-15460.96868Pr-16
RNASeq_FGFR3_CallPAX6repressesR-15460.96868Pr-16
t(14;16)PAX6repressesR-15460.96868Pr-16
t(4;14)PAX6repressesR-15460.96868Pr-16
del13PAX6repressesR-15460.96868Pr-16
t(4;14)_cytogeneticPAX6repressesR-15460.96868Pr-16
FAM46CPAX6activatesR-15551.22022Pr-135
NEBPAX6activatesR-15551.22022Pr-135
t(11;14)PAX6activatesR-15551.22022Pr-135
t(11;14)_cytogeneticPAX6activatesR-15551.22022Pr-135
DIS3PAX6repressesR-15441.54726Pr-87
FAM46CPAX6repressesR-15441.54726Pr-87
IRF4PAX6repressesR-15441.54726Pr-87
t(11;14)PAX6repressesR-15441.54726Pr-87
t(14;16)PAX6repressesR-15441.54726Pr-87
t(4;14)PAX6repressesR-15441.54726Pr-87
amp1qPAX6repressesR-15441.54726Pr-87
del13PAX6repressesR-15441.54726Pr-87
t(11;14)_cytogeneticPAX6repressesR-15441.54726Pr-87
t(14;16)PAX6repressesR-1551-1.63549Pr-96
amp1qPAX6repressesR-1551-1.63549Pr-96
del13PAX6repressesR-1551-1.63549Pr-96
BRAFPAX6activatesR-1552-1.72081Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

t(11;14)PAX6activatesR-1552-1.72081Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

RYR1PAX6activatesR-1552-1.72081Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

amp1qPAX6activatesR-1552-1.72081Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

del13PAX6activatesR-1552-1.72081Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

BRAFPAX6repressesR-15571.87661Pr-71
t(11;14)PAX6repressesR-15571.87661Pr-71
RNASeq_FGFR3_CallPAX6repressesR-15571.87661Pr-71
t(14;16)PAX6repressesR-15571.87661Pr-71
t(4;14)PAX6repressesR-15571.87661Pr-71
RYR1PAX6repressesR-15571.87661Pr-71
amp1qPAX6repressesR-15571.87661Pr-71
del13PAX6repressesR-15571.87661Pr-71
t(11;14)_cytogeneticPAX6repressesR-15571.87661Pr-71
NEBPAX6repressesR-15502.23391Pr-32
t(11;14)PAX6repressesR-15502.23391Pr-32
SYNE1PAX6repressesR-15502.23391Pr-32
BRAFPAX6activatesR-1559-2.4187Pr-37
DIS3PAX6activatesR-1559-2.4187Pr-37
FAM46CPAX6activatesR-1559-2.4187Pr-37
FGFR3PAX6activatesR-1559-2.4187Pr-37
IRF4PAX6activatesR-1559-2.4187Pr-37
PRKD2PAX6activatesR-1559-2.4187Pr-37
t(11;14)PAX6activatesR-1559-2.4187Pr-37
RNASeq_FGFR3_CallPAX6activatesR-1559-2.4187Pr-37
t(14;16)PAX6activatesR-1559-2.4187Pr-37
t(4;14)PAX6activatesR-1559-2.4187Pr-37
amp1qPAX6activatesR-1559-2.4187Pr-37
del13PAX6activatesR-1559-2.4187Pr-37
t(11;14)_cytogeneticPAX6activatesR-1559-2.4187Pr-37
t(4;14)_cytogeneticPAX6activatesR-1559-2.4187Pr-37
DIS3PAX6repressesR-15472.58661Pr-123
FGFR3PAX6repressesR-15472.58661Pr-123
IRF4PAX6repressesR-15472.58661Pr-123
PRKD2PAX6repressesR-15472.58661Pr-123
t(11;14)PAX6repressesR-15472.58661Pr-123
RNASeq_FGFR3_CallPAX6repressesR-15472.58661Pr-123
t(4;14)PAX6repressesR-15472.58661Pr-123
t(11;14)_cytogeneticPAX6repressesR-15472.58661Pr-123
t(4;14)_cytogeneticPAX6repressesR-15472.58661Pr-123
FGFR3PAX6repressesR-1553-2.79929Pr-110
RNASeq_FGFR3_CallPAX6repressesR-1553-2.79929Pr-110
t(14;16)PAX6repressesR-1553-2.79929Pr-110
MYCPAX6repressesR-1553-2.79929Pr-110
t(4;14)PAX6repressesR-1553-2.79929Pr-110
RYR1PAX6repressesR-1553-2.79929Pr-110
amp1qPAX6repressesR-1553-2.79929Pr-110
del13PAX6repressesR-1553-2.79929Pr-110
t(4;14)_cytogeneticPAX6repressesR-1553-2.79929Pr-110
DIS3PAX6repressesR-15583.06238Pr-48
FGFR3PAX6repressesR-15583.06238Pr-48
RNASeq_FGFR3_CallPAX6repressesR-15583.06238Pr-48
t(14;16)PAX6repressesR-15583.06238Pr-48
t(4;14)PAX6repressesR-15583.06238Pr-48
amp1qPAX6repressesR-15583.06238Pr-48
del13PAX6repressesR-15583.06238Pr-48
t(4;14)_cytogeneticPAX6repressesR-15583.06238Pr-48
DIS3PAX6repressesR-15483.58908Pr-52
FGFR3PAX6repressesR-15483.58908Pr-52
RNASeq_FGFR3_CallPAX6repressesR-15483.58908Pr-52
t(14;16)PAX6repressesR-15483.58908Pr-52
t(4;14)PAX6repressesR-15483.58908Pr-52
amp1qPAX6repressesR-15483.58908Pr-52
del13PAX6repressesR-15483.58908Pr-52
t(4;14)_cytogeneticPAX6repressesR-15483.58908Pr-52
NEBPAX6repressesR-15494.66957Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

PRKD2PAX6repressesR-15494.66957Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

t(11;14)PAX6repressesR-15494.66957Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

RNASeq_FGFR3_CallPAX6repressesR-15494.66957Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

t(4;14)PAX6repressesR-15494.66957Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

amp1qPAX6repressesR-15494.66957Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.