Program

Causal Mechanistic Flows with regulons in program Pr-110

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
KIAA1109down-regulatesTFCP2repressesR-1702-0.4338077Pr-110
MAXdown-regulatesTFCP2repressesR-1702-0.4338077Pr-110
t(14;16)_cytogeneticdown-regulatesTFCP2repressesR-1702-0.4338077Pr-110
FGFR3down-regulatesHINFPrepressesR-2623-2.100287Pr-110
MAXdown-regulatesHINFPrepressesR-2623-2.100287Pr-110
NRASup-regulatesHINFPrepressesR-2623-2.100287Pr-110
RNASeq_FGFR3_Calldown-regulatesHINFPrepressesR-2623-2.100287Pr-110
RNASeq_MAFA_Calldown-regulatesHINFPrepressesR-2623-2.100287Pr-110
t(14;16)down-regulatesHINFPrepressesR-2623-2.100287Pr-110
MYCup-regulatesHINFPrepressesR-2623-2.100287Pr-110
t(4;14)down-regulatesHINFPrepressesR-2623-2.100287Pr-110
t(14;16)_cytogeneticdown-regulatesHINFPrepressesR-2623-2.100287Pr-110
t(4;14)_cytogeneticdown-regulatesHINFPrepressesR-2623-2.100287Pr-110
BAI3down-regulatesKLF4activatesR-2755-2.5976510Pr-110
FGFR3up-regulatesKLF4activatesR-2755-2.5976510Pr-110
KDM3Bdown-regulatesKLF4activatesR-2755-2.5976510Pr-110
MAXup-regulatesKLF4activatesR-2755-2.5976510Pr-110
MYH2down-regulatesKLF4activatesR-2755-2.5976510Pr-110
NRASdown-regulatesKLF4activatesR-2755-2.5976510Pr-110
PRKD2up-regulatesKLF4activatesR-2755-2.5976510Pr-110
RNASeq_FGFR3_Callup-regulatesKLF4activatesR-2755-2.5976510Pr-110
MYCdown-regulatesKLF4activatesR-2755-2.5976510Pr-110
t(4;14)up-regulatesKLF4activatesR-2755-2.5976510Pr-110
del13up-regulatesKLF4activatesR-2755-2.5976510Pr-110
t(4;14)_cytogeneticup-regulatesKLF4activatesR-2755-2.5976510Pr-110
NRASdown-regulatesNR3C1activatesR-3192-2.641357Pr-110
RNASeq_MAFA_Callup-regulatesNR3C1activatesR-3192-2.641357Pr-110
RNASeq_MAFB_Callup-regulatesNR3C1activatesR-3192-2.641357Pr-110
t(14;16)up-regulatesNR3C1activatesR-3192-2.641357Pr-110
TRAF3up-regulatesNR3C1activatesR-3192-2.641357Pr-110
del13up-regulatesNR3C1activatesR-3192-2.641357Pr-110
t(14;16)_cytogeneticup-regulatesNR3C1activatesR-3192-2.641357Pr-110
t(14;16)up-regulatesARID5AactivatesR-605-2.713538Pr-110
amp1qup-regulatesARID5AactivatesR-605-2.713538Pr-110
del13up-regulatesARID5AactivatesR-605-2.713538Pr-110
PTPRDdown-regulatesMAFKactivatesR-2809-2.713959Pr-110
amp1qup-regulatesMAFKactivatesR-2809-2.713959Pr-110
del13up-regulatesMAFKactivatesR-2809-2.713959Pr-110
FGFR3down-regulatesPAX6repressesR-1553-2.799298Pr-110
RNASeq_FGFR3_Calldown-regulatesPAX6repressesR-1553-2.799298Pr-110
t(14;16)down-regulatesPAX6repressesR-1553-2.799298Pr-110
MYCup-regulatesPAX6repressesR-1553-2.799298Pr-110
t(4;14)down-regulatesPAX6repressesR-1553-2.799298Pr-110
RYR1up-regulatesPAX6repressesR-1553-2.799298Pr-110
amp1qdown-regulatesPAX6repressesR-1553-2.799298Pr-110
del13down-regulatesPAX6repressesR-1553-2.799298Pr-110
t(4;14)_cytogeneticdown-regulatesPAX6repressesR-1553-2.799298Pr-110
MYCdown-regulatesMAFBactivatesR-1749-3.135996Pr-110
ROBO2down-regulatesMAFBactivatesR-1749-3.135996Pr-110
CSMD3down-regulatesCEBPBactivatesR-1771-3.835589Pr-110
NRASdown-regulatesCEBPBactivatesR-1771-3.835589Pr-110
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-1771-3.835589Pr-110
t(4;14)up-regulatesCEBPBactivatesR-1771-3.835589Pr-110
t(4;14)_cytogeneticup-regulatesCEBPBactivatesR-1771-3.835589Pr-110
FGFR3down-regulatesHINFPrepressesR-2622-4.193837Pr-110
NRASup-regulatesHINFPrepressesR-2622-4.193837Pr-110
PRKD2down-regulatesHINFPrepressesR-2622-4.193837Pr-110
RNASeq_FGFR3_Calldown-regulatesHINFPrepressesR-2622-4.193837Pr-110
MYCup-regulatesHINFPrepressesR-2622-4.193837Pr-110
t(4;14)down-regulatesHINFPrepressesR-2622-4.193837Pr-110
TRAF3down-regulatesHINFPrepressesR-2622-4.193837Pr-110
t(4;14)_cytogeneticdown-regulatesHINFPrepressesR-2622-4.193837Pr-110
BAI3down-regulatesTCF4activatesR-3001-4.245149Pr-110
CMYA5down-regulatesTCF4activatesR-3001-4.245149Pr-110
FGFR3up-regulatesTCF4activatesR-3001-4.245149Pr-110
KDM3Bdown-regulatesTCF4activatesR-3001-4.245149Pr-110
KMT2Bdown-regulatesTCF4activatesR-3001-4.245149Pr-110
LRP2down-regulatesTCF4activatesR-3001-4.245149Pr-110
LTBup-regulatesTCF4activatesR-3001-4.245149Pr-110
NRASdown-regulatesTCF4activatesR-3001-4.245149Pr-110
PRKD2up-regulatesTCF4activatesR-3001-4.245149Pr-110
t(11;14)down-regulatesTCF4activatesR-3001-4.245149Pr-110
RNASeq_FGFR3_Callup-regulatesTCF4activatesR-3001-4.245149Pr-110
MYCdown-regulatesTCF4activatesR-3001-4.245149Pr-110
t(4;14)up-regulatesTCF4activatesR-3001-4.245149Pr-110
TRAF3up-regulatesTCF4activatesR-3001-4.245149Pr-110
del13up-regulatesTCF4activatesR-3001-4.245149Pr-110
t(11;14)_cytogeneticdown-regulatesTCF4activatesR-3001-4.245149Pr-110
t(4;14)_cytogeneticup-regulatesTCF4activatesR-3001-4.245149Pr-110
NRASdown-regulatesNFATC2activatesR-1691-4.2723512Pr-110
RNASeq_MAFA_Callup-regulatesNFATC2activatesR-1691-4.2723512Pr-110
RNASeq_MAFB_Callup-regulatesNFATC2activatesR-1691-4.2723512Pr-110
t(14;16)up-regulatesNFATC2activatesR-1691-4.2723512Pr-110
del13up-regulatesNFATC2activatesR-1691-4.2723512Pr-110
t(14;16)_cytogeneticup-regulatesNFATC2activatesR-1691-4.2723512Pr-110
NRASdown-regulatesNR3C1activatesR-3184-4.3980116Pr-110
PRDM1up-regulatesNR3C1activatesR-3184-4.3980116Pr-110
t(11;14)down-regulatesNR3C1activatesR-3184-4.3980116Pr-110
TRAF3up-regulatesNR3C1activatesR-3184-4.3980116Pr-110
del13up-regulatesNR3C1activatesR-3184-4.3980116Pr-110
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-3184-4.3980116Pr-110
FAT3up-regulatesSP1repressesR-2724-4.6517619Pr-110
PTPRDup-regulatesSP1repressesR-2724-4.6517619Pr-110
RNASeq_MAFA_Callup-regulatesSP1repressesR-2724-4.6517619Pr-110
RNASeq_MAFB_Callup-regulatesSP1repressesR-2724-4.6517619Pr-110
t(14;16)up-regulatesSP1repressesR-2724-4.6517619Pr-110
ROBO2up-regulatesSP1repressesR-2724-4.6517619Pr-110
ZNF462up-regulatesSP1repressesR-2724-4.6517619Pr-110
FAM46Cdown-regulatesMAFactivatesR-105-4.7785313Pr-110
FGFR3up-regulatesMAFactivatesR-105-4.7785313Pr-110
NRASdown-regulatesMAFactivatesR-105-4.7785313Pr-110
t(11;14)down-regulatesMAFactivatesR-105-4.7785313Pr-110
RNASeq_FGFR3_Callup-regulatesMAFactivatesR-105-4.7785313Pr-110
MYCdown-regulatesMAFactivatesR-105-4.7785313Pr-110
t(4;14)up-regulatesMAFactivatesR-105-4.7785313Pr-110
del13up-regulatesMAFactivatesR-105-4.7785313Pr-110
t(4;14)_cytogeneticup-regulatesMAFactivatesR-105-4.7785313Pr-110
NRASdown-regulatesARID3AactivatesR-1349-4.865958Pr-110
PRUNE2down-regulatesARID3AactivatesR-1349-4.865958Pr-110
t(11;14)down-regulatesARID3AactivatesR-1349-4.865958Pr-110
RNASeq_MAFA_Callup-regulatesARID3AactivatesR-1349-4.865958Pr-110
TRAF3up-regulatesARID3AactivatesR-1349-4.865958Pr-110
FGFR3down-regulatesRARBrepressesR-1110-5.348226Pr-110
t(11;14)up-regulatesRARBrepressesR-1110-5.348226Pr-110
RNASeq_FGFR3_Calldown-regulatesRARBrepressesR-1110-5.348226Pr-110
t(4;14)down-regulatesRARBrepressesR-1110-5.348226Pr-110
RYR1up-regulatesRARBrepressesR-1110-5.348226Pr-110
UBR4up-regulatesRARBrepressesR-1110-5.348226Pr-110
ZNF462up-regulatesRARBrepressesR-1110-5.348226Pr-110
del13down-regulatesRARBrepressesR-1110-5.348226Pr-110
t(4;14)_cytogeneticdown-regulatesRARBrepressesR-1110-5.348226Pr-110
CMYA5down-regulatesCEBPBactivatesR-1764-5.3858513Pr-110
FGFR3up-regulatesCEBPBactivatesR-1764-5.3858513Pr-110
LTBup-regulatesCEBPBactivatesR-1764-5.3858513Pr-110
NRASdown-regulatesCEBPBactivatesR-1764-5.3858513Pr-110
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-1764-5.3858513Pr-110
t(4;14)up-regulatesCEBPBactivatesR-1764-5.3858513Pr-110
t(4;14)_cytogeneticup-regulatesCEBPBactivatesR-1764-5.3858513Pr-110

Regulons in program Pr-110

Regulon Cox Hazard Ratio # genes # causal flows
R-1702-0.43380773
R-2623-2.10028710
R-2755-2.597651012
R-3192-2.6413577
R-605-2.7135383
R-2809-2.7139593
R-1553-2.7992989
R-1749-3.1359962
R-1771-3.8355895
R-2622-4.1938378
R-3001-4.24514917
R-1691-4.27235126
R-3184-4.39801166
R-2724-4.65176197
R-105-4.77853139
R-1349-4.8659585
R-1110-5.3482269
R-1764-5.38585137

Genes in program Pr-110

EnsEMBL IdEntrez IdPreferred
ENSG00000180263 55785FGD6
ENSG00000241484 23779ARHGAP8

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions