Program

Causal Mechanistic Flows with regulons in program Pr-127

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CMYA5down-regulatesATF4activatesR-930.2001229Pr-127
MYO10down-regulatesATF4activatesR-930.2001229Pr-127
t(11;14)up-regulatesATF4activatesR-930.2001229Pr-127
RNASeq_FGFR3_Callup-regulatesATF4activatesR-930.2001229Pr-127
t(11;14)_cytogeneticup-regulatesATF4activatesR-930.2001229Pr-127
EYSdown-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
FAM46Cdown-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
FGFR3up-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
NRASdown-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
PRKD2up-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
RNASeq_FGFR3_Callup-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
t(4;14)up-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
t(4;14)_cytogeneticup-regulatesFOX3AactivatesR-1513-0.59826710Pr-127
FAM46Cdown-regulatesNFE2L1activatesR-18241.110968Pr-127
NRASdown-regulatesNFE2L1activatesR-18241.110968Pr-127
t(11;14)up-regulatesNFE2L1activatesR-18241.110968Pr-127
RNASeq_FGFR3_Callup-regulatesNFE2L1activatesR-18241.110968Pr-127
t(4;14)up-regulatesNFE2L1activatesR-18241.110968Pr-127
t(11;14)_cytogeneticup-regulatesNFE2L1activatesR-18241.110968Pr-127
t(4;14)_cytogeneticup-regulatesNFE2L1activatesR-18241.110968Pr-127
DCHS1up-regulatesCEBPBactivatesR-17621.1685218Pr-127
FAM46Cdown-regulatesCEBPBactivatesR-17621.1685218Pr-127
FGFR3up-regulatesCEBPBactivatesR-17621.1685218Pr-127
HUWE1up-regulatesCEBPBactivatesR-17621.1685218Pr-127
IRF4up-regulatesCEBPBactivatesR-17621.1685218Pr-127
LTBup-regulatesCEBPBactivatesR-17621.1685218Pr-127
PRKD2up-regulatesCEBPBactivatesR-17621.1685218Pr-127
RELNup-regulatesCEBPBactivatesR-17621.1685218Pr-127
t(11;14)up-regulatesCEBPBactivatesR-17621.1685218Pr-127
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-17621.1685218Pr-127
t(4;14)up-regulatesCEBPBactivatesR-17621.1685218Pr-127
SETD2up-regulatesCEBPBactivatesR-17621.1685218Pr-127
TTNdown-regulatesCEBPBactivatesR-17621.1685218Pr-127
DCHS1down-regulatesTRAF4repressesR-30391.2792214Pr-127
DIS3down-regulatesTRAF4repressesR-30391.2792214Pr-127
RNASeq_FGFR3_Calldown-regulatesTRAF4repressesR-30391.2792214Pr-127
t(4;14)down-regulatesTRAF4repressesR-30391.2792214Pr-127
ZFHX3down-regulatesTRAF4repressesR-30391.2792214Pr-127
del17down-regulatesTRAF4repressesR-30391.2792214Pr-127
RNASeq_FGFR3_Calldown-regulatesSPI1repressesR-26081.359925Pr-127
MYCdown-regulatesSPI1repressesR-26081.359925Pr-127
t(4;14)down-regulatesSPI1repressesR-26081.359925Pr-127
SYNE1down-regulatesSPI1repressesR-26081.359925Pr-127
SYNE1up-regulatesZBTB3activatesR-12681.428829Pr-127
TP53up-regulatesZBTB3activatesR-12681.428829Pr-127
MYCdown-regulatesPOU2F1repressesR-851.4301127Pr-127
del17down-regulatesPOU2F1repressesR-851.4301127Pr-127
DCHS1up-regulatesSP1activatesR-27181.430631Pr-127
FAM46Cdown-regulatesSP1activatesR-27181.430631Pr-127
FGFR3up-regulatesSP1activatesR-27181.430631Pr-127
IRF4up-regulatesSP1activatesR-27181.430631Pr-127
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27181.430631Pr-127
t(4;14)up-regulatesSP1activatesR-27181.430631Pr-127
DNAH10down-regulatesSRFrepressesR-17841.5428225Pr-127
FAM46Cup-regulatesSRFrepressesR-17841.5428225Pr-127
IRF4down-regulatesSRFrepressesR-17841.5428225Pr-127
MXRA5down-regulatesSRFrepressesR-17841.5428225Pr-127
PRKD2down-regulatesSRFrepressesR-17841.5428225Pr-127
t(11;14)down-regulatesSRFrepressesR-17841.5428225Pr-127
RNASeq_FGFR3_Calldown-regulatesSRFrepressesR-17841.5428225Pr-127
MYCdown-regulatesSRFrepressesR-17841.5428225Pr-127
t(4;14)down-regulatesSRFrepressesR-17841.5428225Pr-127
SETD2down-regulatesSRFrepressesR-17841.5428225Pr-127
TP53down-regulatesSRFrepressesR-17841.5428225Pr-127
IRF4down-regulatesSPDEFrepressesR-19641.9610612Pr-127
t(11;14)down-regulatesSPDEFrepressesR-19641.9610612Pr-127
SETD2down-regulatesSPDEFrepressesR-19641.9610612Pr-127
TP53down-regulatesSPDEFrepressesR-19641.9610612Pr-127
ZFHX3down-regulatesSPDEFrepressesR-19641.9610612Pr-127
MAXdown-regulatesNFATC1repressesR-22033.034358Pr-127

Regulons in program Pr-127

Regulon Cox Hazard Ratio # genes # causal flows
R-930.20012295
R-1513-0.598267108
R-18241.1109687
R-17621.168521813
R-30391.27922146
R-26081.3599254
R-12681.4288292
R-851.43011272
R-27181.4306316
R-17841.542822511
R-19641.96106125
R-22033.0343581

Genes in program Pr-127

EnsEMBL IdEntrez IdPreferred
ENSG00000177272 3738KCNA3
ENSG00000182885
ENSG00000196329 55340GIMAP5
ENSG00000196812 80345ZSCAN16
ENSG00000197746 5660PSAP
ENSG00000198324 144717FAM109A
ENSG00000198742 57154SMURF1
ENSG00000198746 63906GPATCH3
ENSG00000198755 4736RPL10A
ENSG00000204099
ENSG00000224940

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions