Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation LTB

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TEAD1up-regulatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

FOXJ1up-regulatesR-1850-0.0601821Pr-10
ETV5up-regulatesR-3420.139146Pr-117
CREB5up-regulatesR-7760.145302Pr-12
ZFXup-regulatesR-1920-0.319605Pr-129
CEBPBup-regulatesR-1768-0.337185Pr-109
ZFXup-regulatesR-1917-0.446489Pr-6
PBX1up-regulatesR-21080.496117Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

ZFXup-regulatesR-19260.529957Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

ENSG00000143995up-regulatesR-133-0.60449Pr-138
ELK4up-regulatesR-7670.613021Pr-0
MEF2Dup-regulatesR-8770.682478Pr-55
TCF4up-regulatesR-29990.734651Pr-131
SOX4up-regulatesR-2189-0.776926Pr-12
PBX1up-regulatesR-2109-0.833545Pr-5
CEBPBup-regulatesR-1777-0.838666Pr-129
NFYAup-regulatesR-14790.89477Pr-129
IRF7down-regulatesR-1092-0.976053Pr-40
IRF7down-regulatesR-1090-1.0469Pr-40
SOX4up-regulatesR-2184-1.09056Pr-113
MZF1down-regulatesR-30161.15326Pr-5
CEBPBup-regulatesR-17621.16852Pr-127
ATF2up-regulatesR-30921.26346Pr-111
RORAup-regulatesR-2279-1.26921Pr-27
RARBdown-regulatesR-11061.29549Pr-108
HOXD1up-regulatesR-13031.32893Pr-131
CEBPBup-regulatesR-17651.33752Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ENSG00000176887up-regulatesR-1891-1.3829Pr-99
KLF4up-regulatesR-27571.83252Pr-31

Genes (4)

TTC3, ARL4C, GTF2F2, IFRD2

Regulons (4)

R-3135, R-394, R-1836, R-2757

MZF1down-regulatesR-30271.86359Pr-108
IRF7down-regulatesR-1089-2.10194Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

RUNX2up-regulatesR-12832.3191Pr-123
RORAup-regulatesR-2278-2.37391Pr-113
RUNX2up-regulatesR-12842.62887Pr-108
BRCA1up-regulatesR-10312.71498Pr-123
PEBP1up-regulatesR-17552.80711Pr-1
IRF7down-regulatesR-1091-2.83714Pr-135
ELK4up-regulatesR-766-2.86246Pr-36
ENSG00000176887up-regulatesR-19012.8972Pr-48
MEF2Dup-regulatesR-8682.92774Pr-108
SOX4up-regulatesR-21772.93862Pr-108
ENSG00000176887up-regulatesR-1890-2.97256Pr-135
KLF4up-regulatesR-2752-2.99913Pr-36
TEAD1up-regulatesR-12193.01346Pr-48
ETV5up-regulatesR-340-3.04337Pr-36
MEF2Dup-regulatesR-8753.04847Pr-108
ENSG00000175832up-regulatesR-312-3.06Pr-36
TERF1up-regulatesR-2413-3.06508Pr-118
ENSG00000176887up-regulatesR-18963.13558Pr-48
HOXD1up-regulatesR-13013.24332Pr-108
PBX1up-regulatesR-21053.24509Pr-108
TEFdown-regulatesR-2406-3.30554Pr-135
TEAD1up-regulatesR-12143.31075Pr-108
ENSG00000165066down-regulatesR-30773.31834Pr-52
PEBP1up-regulatesR-1752-3.39081Pr-36
DLX4up-regulatesR-19863.40059Pr-52
PPARGdown-regulatesR-28293.43725Pr-48
ZFXup-regulatesR-19293.48789Pr-117
CEBPBup-regulatesR-17593.59248Pr-108
ENSG00000176887up-regulatesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

TEAD1up-regulatesR-12163.63699Pr-108
NFYAup-regulatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ENSG00000136574up-regulatesR-353.65653Pr-123
ENSG00000136574up-regulatesR-343.74664Pr-108
CEBPBup-regulatesR-1775-3.79192Pr-36
MEF2Dup-regulatesR-8703.82168Pr-52
YY1up-regulatesR-25253.91807Pr-122
TCF4up-regulatesR-29983.92524Pr-75
CEBPBup-regulatesR-17724.02047Pr-122
MEF2Dup-regulatesR-8714.1859Pr-48
SOX4up-regulatesR-21784.19485Pr-108
TCF4up-regulatesR-3001-4.24514Pr-110
YY1up-regulatesR-25244.48874Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

ESRRAdown-regulatesR-2740-4.64571Pr-36
ENSG00000102678up-regulatesR-2325.31311Pr-108
CEBPBup-regulatesR-1764-5.38585Pr-110

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions