Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation EYS

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
NR4A2up-regulatesR-1719-0.189674Pr-23
FOX3Adown-regulatesR-1513-0.598267Pr-127
SATB1down-regulatesR-10741.38828Pr-111
RUNX2down-regulatesR-12832.3191Pr-123
SOX4down-regulatesR-21772.93862Pr-108
PBX1down-regulatesR-21063.00005Pr-123
TEAD1down-regulatesR-12163.63699Pr-108
ZEB1up-regulatesR-2244-4.47087Pr-35

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions