Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

- SRY-box transcription factor 11

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
ENSG00000176887 P35716

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator:

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
FAT3activatesR-18930.370377Pr-128
IRF4activatesR-18930.370377Pr-128
PRKD2activatesR-18930.370377Pr-128
t(11;14)activatesR-18930.370377Pr-128
t(4;14)activatesR-18930.370377Pr-128
t(11;14)_cytogeneticactivatesR-18930.370377Pr-128
ATMactivatesR-18990.507358Pr-50
DCHS1activatesR-18990.507358Pr-50
DIS3activatesR-18990.507358Pr-50
t(14;16)activatesR-18990.507358Pr-50
TRIOactivatesR-18990.507358Pr-50
amp1qactivatesR-18990.507358Pr-50
BRAFrepressesR-1891-1.3829Pr-99
DIS3repressesR-1891-1.3829Pr-99
FAM46CrepressesR-1891-1.3829Pr-99
FGFR3repressesR-1891-1.3829Pr-99
HUWE1repressesR-1891-1.3829Pr-99
IRF4repressesR-1891-1.3829Pr-99
LTBrepressesR-1891-1.3829Pr-99
NFKB2repressesR-1891-1.3829Pr-99
PRKD2repressesR-1891-1.3829Pr-99
t(11;14)repressesR-1891-1.3829Pr-99
RNASeq_FGFR3_CallrepressesR-1891-1.3829Pr-99
t(14;16)repressesR-1891-1.3829Pr-99
t(4;14)repressesR-1891-1.3829Pr-99
TRIOrepressesR-1891-1.3829Pr-99
t(11;14)_cytogeneticrepressesR-1891-1.3829Pr-99
t(4;14)_cytogeneticrepressesR-1891-1.3829Pr-99
DIS3activatesR-18941.46342Pr-58
FGFR3activatesR-18941.46342Pr-58
t(11;14)activatesR-18941.46342Pr-58
RNASeq_FGFR3_CallactivatesR-18941.46342Pr-58
t(4;14)activatesR-18941.46342Pr-58
t(11;14)_cytogeneticactivatesR-18941.46342Pr-58
t(4;14)_cytogeneticactivatesR-18941.46342Pr-58
FGFR3activatesR-19001.8751Pr-122
PRKD2activatesR-19001.8751Pr-122
RNASeq_FGFR3_CallactivatesR-19001.8751Pr-122
t(4;14)activatesR-19001.8751Pr-122
TP53activatesR-19001.8751Pr-122
t(4;14)_cytogeneticactivatesR-19001.8751Pr-122
DIS3repressesR-1898-2.61611Pr-36
DNAH10repressesR-1898-2.61611Pr-36
FAM46CrepressesR-1898-2.61611Pr-36
FRAS1repressesR-1898-2.61611Pr-36
IRF4repressesR-1898-2.61611Pr-36
MAXrepressesR-1898-2.61611Pr-36
PRKD2repressesR-1898-2.61611Pr-36
t(11;14)repressesR-1898-2.61611Pr-36
RNASeq_FGFR3_CallrepressesR-1898-2.61611Pr-36
t(14;16)repressesR-1898-2.61611Pr-36
t(4;14)repressesR-1898-2.61611Pr-36
SETD2repressesR-1898-2.61611Pr-36
TRIOrepressesR-1898-2.61611Pr-36
amp1qrepressesR-1898-2.61611Pr-36
del13repressesR-1898-2.61611Pr-36
t(11;14)_cytogeneticrepressesR-1898-2.61611Pr-36
t(4;14)_cytogeneticrepressesR-1898-2.61611Pr-36
DCHS1activatesR-19012.8972Pr-48
DIS3activatesR-19012.8972Pr-48
FAM46CactivatesR-19012.8972Pr-48
FGFR3activatesR-19012.8972Pr-48
LTBactivatesR-19012.8972Pr-48
RNASeq_FGFR3_CallactivatesR-19012.8972Pr-48
t(14;16)activatesR-19012.8972Pr-48
t(4;14)activatesR-19012.8972Pr-48
TRIOactivatesR-19012.8972Pr-48
amp1qactivatesR-19012.8972Pr-48
del13activatesR-19012.8972Pr-48
t(4;14)_cytogeneticactivatesR-19012.8972Pr-48
FGFR3repressesR-1890-2.97256Pr-135
LTBrepressesR-1890-2.97256Pr-135
PRKD2repressesR-1890-2.97256Pr-135
RNASeq_FGFR3_CallrepressesR-1890-2.97256Pr-135
t(4;14)repressesR-1890-2.97256Pr-135
amp1qrepressesR-1890-2.97256Pr-135
del13repressesR-1890-2.97256Pr-135
t(4;14)_cytogeneticrepressesR-1890-2.97256Pr-135
DCHS1activatesR-18963.13558Pr-48
DIS3activatesR-18963.13558Pr-48
FGFR3activatesR-18963.13558Pr-48
LTBactivatesR-18963.13558Pr-48
RNASeq_FGFR3_CallactivatesR-18963.13558Pr-48
t(14;16)activatesR-18963.13558Pr-48
t(4;14)activatesR-18963.13558Pr-48
amp1qactivatesR-18963.13558Pr-48
del13activatesR-18963.13558Pr-48
t(4;14)_cytogeneticactivatesR-18963.13558Pr-48
DIS3activatesR-18923.42989Pr-122
DNAH10activatesR-18923.42989Pr-122
FAM46CactivatesR-18923.42989Pr-122
FGFR3activatesR-18923.42989Pr-122
IRF4activatesR-18923.42989Pr-122
MAXactivatesR-18923.42989Pr-122
PRKD2activatesR-18923.42989Pr-122
t(11;14)activatesR-18923.42989Pr-122
RNASeq_FGFR3_CallactivatesR-18923.42989Pr-122
t(14;16)activatesR-18923.42989Pr-122
t(4;14)activatesR-18923.42989Pr-122
TP53activatesR-18923.42989Pr-122
amp1qactivatesR-18923.42989Pr-122
del13activatesR-18923.42989Pr-122
t(11;14)_cytogeneticactivatesR-18923.42989Pr-122
t(4;14)_cytogeneticactivatesR-18923.42989Pr-122
FAM46CrepressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

FRAS1repressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

HUWE1repressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

IRF4repressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

LTBrepressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

PRKD2repressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

t(11;14)repressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

RNASeq_FGFR3_CallrepressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

t(4;14)repressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

TP53repressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

t(11;14)_cytogeneticrepressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

t(4;14)_cytogeneticrepressesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

DCHS1activatesR-18953.70985Pr-50
DIS3activatesR-18953.70985Pr-50
FAM46CactivatesR-18953.70985Pr-50
FAT3activatesR-18953.70985Pr-50
FGFR3activatesR-18953.70985Pr-50
IRF4activatesR-18953.70985Pr-50
RNASeq_FGFR3_CallactivatesR-18953.70985Pr-50
t(14;16)activatesR-18953.70985Pr-50
t(4;14)activatesR-18953.70985Pr-50
TRIOactivatesR-18953.70985Pr-50
amp1qactivatesR-18953.70985Pr-50
t(4;14)_cytogeneticactivatesR-18953.70985Pr-50
ATMactivatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

DCHS1activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

DIS3activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FAM46CactivatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FAT3activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FGFR3activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAXactivatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_FGFR3_CallactivatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(14;16)activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SETD2activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

TRIOactivatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

amp1qactivatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

del13activatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)_cytogeneticactivatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.