Program

Causal Mechanistic Flows with regulons in program Pr-55

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3up-regulatesMEF2DactivatesR-8770.6824787Pr-55
FGFR3up-regulatesMEF2DactivatesR-8770.6824787Pr-55
LTBup-regulatesMEF2DactivatesR-8770.6824787Pr-55
t(11;14)down-regulatesMEF2DactivatesR-8770.6824787Pr-55
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-8770.6824787Pr-55
t(14;16)up-regulatesMEF2DactivatesR-8770.6824787Pr-55
t(4;14)up-regulatesMEF2DactivatesR-8770.6824787Pr-55
TRAF3up-regulatesMEF2DactivatesR-8770.6824787Pr-55
amp1qup-regulatesMEF2DactivatesR-8770.6824787Pr-55
del13up-regulatesMEF2DactivatesR-8770.6824787Pr-55
t(11;14)_cytogeneticdown-regulatesMEF2DactivatesR-8770.6824787Pr-55
t(14;16)_cytogeneticup-regulatesMEF2DactivatesR-8770.6824787Pr-55
t(4;14)_cytogeneticup-regulatesMEF2DactivatesR-8770.6824787Pr-55
COL12A1down-regulatesNF1repressesR-129-0.6872716Pr-55
OBSCNdown-regulatesNF1repressesR-129-0.6872716Pr-55
t(11;14)up-regulatesNF1repressesR-129-0.6872716Pr-55
ROBO1down-regulatesNF1repressesR-129-0.6872716Pr-55
t(11;14)_cytogeneticup-regulatesNF1repressesR-129-0.6872716Pr-55
KIAA1244down-regulatesSPI1repressesR-26021.5994449Pr-55
PTPRDdown-regulatesSPI1repressesR-26021.5994449Pr-55
t(11;14)up-regulatesSPI1repressesR-26021.5994449Pr-55
RNASeq_FGFR3_Calldown-regulatesSPI1repressesR-26021.5994449Pr-55
t(4;14)down-regulatesSPI1repressesR-26021.5994449Pr-55
TRAF3down-regulatesSPI1repressesR-26021.5994449Pr-55
t(14;16)_cytogeneticdown-regulatesSPI1repressesR-26021.5994449Pr-55
t(11;14)down-regulatesENSG00000186564activatesR-4781.7145821Pr-55
TRAF3up-regulatesENSG00000186564activatesR-4781.7145821Pr-55
DSTdown-regulatesPATZ1repressesR-21962.394098Pr-55
KIAA1244down-regulatesPATZ1repressesR-21962.394098Pr-55
KRASup-regulatesPATZ1repressesR-21962.394098Pr-55
NRASup-regulatesPATZ1repressesR-21962.394098Pr-55
t(11;14)up-regulatesPATZ1repressesR-21962.394098Pr-55
TP53up-regulatesPATZ1repressesR-21962.394098Pr-55
TRAF3down-regulatesPATZ1repressesR-21962.394098Pr-55
amp1qdown-regulatesPATZ1repressesR-21962.394098Pr-55
del13down-regulatesPATZ1repressesR-21962.394098Pr-55
t(11;14)_cytogeneticup-regulatesPATZ1repressesR-21962.394098Pr-55
AHNAK2down-regulatesGABPB1repressesR-19442.591916Pr-55
FAT3down-regulatesGABPB1repressesR-19442.591916Pr-55
MYO10down-regulatesGABPB1repressesR-19442.591916Pr-55
PTPRDdown-regulatesGABPB1repressesR-19442.591916Pr-55
t(11;14)up-regulatesGABPB1repressesR-19442.591916Pr-55

Regulons in program Pr-55

Regulon Cox Hazard Ratio # genes # causal flows
R-8770.682478713
R-129-0.68727165
R-26021.59944497
R-4781.71458212
R-21962.39409810
R-19442.5919165

Genes in program Pr-55

EnsEMBL IdEntrez IdPreferred
ENSG00000184162 126382NR2C2AP
ENSG00000184261 56660KCNK12
ENSG00000204628 10399RACK1
ENSG00000213160 151230KLHL23
ENSG00000266967 80755AARSD1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions