Program

Causal Mechanistic Flows with regulons in program Pr-4

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
KALRNup-regulatesNFYCrepressesR-2950.1120359Pr-4
MYCdown-regulatesNFYCrepressesR-2950.1120359Pr-4
amp1qdown-regulatesNFYCrepressesR-2950.1120359Pr-4
AHNAK2down-regulatesFOXJ3activatesR-28790.13546232Pr-4
NEBdown-regulatesFOXJ3activatesR-28790.13546232Pr-4
SYNE1down-regulatesFOXJ3activatesR-28790.13546232Pr-4
TACC2down-regulatesFOXJ3activatesR-28790.13546232Pr-4
amp1qup-regulatesFOXJ3activatesR-28790.13546232Pr-4
del13up-regulatesFOXJ3activatesR-28790.13546232Pr-4
FAM46Cdown-regulatesPARP1repressesR-26390.2554419Pr-4
FAT3up-regulatesPARP1repressesR-26390.2554419Pr-4
MACF1up-regulatesPARP1repressesR-26390.2554419Pr-4
MAXup-regulatesPARP1repressesR-26390.2554419Pr-4
FAT3up-regulatesZNF143repressesR-2318-0.278627Pr-4
NRASdown-regulatesZNF143repressesR-2318-0.278627Pr-4
SYNE1up-regulatesZNF143repressesR-2318-0.278627Pr-4
t(14;16)_cytogeneticup-regulatesZNF143repressesR-2318-0.278627Pr-4
AHNAK2down-regulatesTRAF4activatesR-3043-0.3554136Pr-4
DIS3down-regulatesTRAF4activatesR-3043-0.3554136Pr-4
FAT3down-regulatesTRAF4activatesR-3043-0.3554136Pr-4
MACF1down-regulatesTRAF4activatesR-3043-0.3554136Pr-4
MAGI1down-regulatesTRAF4activatesR-3043-0.3554136Pr-4
MAXdown-regulatesTRAF4activatesR-3043-0.3554136Pr-4
MYO10down-regulatesTRAF4activatesR-3043-0.3554136Pr-4
RNASeq_MAFA_Calldown-regulatesTRAF4activatesR-3043-0.3554136Pr-4
DMDdown-regulatesNFE2L2repressesR-19080.42568913Pr-4
ZFHX3up-regulatesNFE2L2repressesR-19080.42568913Pr-4
amp1qdown-regulatesNFE2L2repressesR-19080.42568913Pr-4
del13down-regulatesNFE2L2repressesR-19080.42568913Pr-4
FAT3down-regulatesNFATC2activatesR-1695-0.4543718Pr-4
amp1qup-regulatesNFATC2activatesR-1695-0.4543718Pr-4
del13up-regulatesNFATC2activatesR-1695-0.4543718Pr-4
FGFR3down-regulatesPAX6repressesR-1554-0.53947Pr-4
t(4;14)down-regulatesPAX6repressesR-1554-0.53947Pr-4
amp1qdown-regulatesPAX6repressesR-1554-0.53947Pr-4
del13down-regulatesPAX6repressesR-1554-0.53947Pr-4
AHNAK2down-regulatesZNF281activatesR-2485-0.6417412Pr-4
DMDup-regulatesZNF281activatesR-2485-0.6417412Pr-4
PTPRDdown-regulatesZNF281activatesR-2485-0.6417412Pr-4
RNASeq_MAFB_Calldown-regulatesZNF281activatesR-2485-0.6417412Pr-4
amp1qup-regulatesZNF281activatesR-2485-0.6417412Pr-4
del13up-regulatesZNF281activatesR-2485-0.6417412Pr-4
CYLDdown-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
DCHS1up-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
FAM46Cdown-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
IRF4up-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
MAXup-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
PRKD2up-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
t(11;14)up-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
SETD2up-regulatesCEBPBrepressesR-1767-0.66120810Pr-4
FGFR3up-regulatesCREB5activatesR-777-0.6906477Pr-4
t(4;14)up-regulatesCREB5activatesR-777-0.6906477Pr-4
amp1qup-regulatesCREB5activatesR-777-0.6906477Pr-4
del13up-regulatesCREB5activatesR-777-0.6906477Pr-4
AHNAK2down-regulatesCEBPGactivatesR-443-0.78985211Pr-4
FAT3down-regulatesCEBPGactivatesR-443-0.78985211Pr-4
KALRNdown-regulatesCEBPGactivatesR-443-0.78985211Pr-4
MACF1down-regulatesCEBPGactivatesR-443-0.78985211Pr-4
PTPRDdown-regulatesCEBPGactivatesR-443-0.78985211Pr-4
SYNE1down-regulatesCEBPGactivatesR-443-0.78985211Pr-4
TACC2down-regulatesCEBPGactivatesR-443-0.78985211Pr-4
del13up-regulatesCEBPGactivatesR-443-0.78985211Pr-4
NRASdown-regulatesPEBP1repressesR-17530.9771868Pr-4
RNASeq_FGFR3_Callup-regulatesPEBP1repressesR-17530.9771868Pr-4
t(4;14)up-regulatesPEBP1repressesR-17530.9771868Pr-4
t(14;16)_cytogeneticup-regulatesPEBP1repressesR-17530.9771868Pr-4
t(4;14)_cytogeneticup-regulatesPEBP1repressesR-17530.9771868Pr-4
FGFR3up-regulatesPBX1activatesR-2114-0.9954526Pr-4
PTPRDdown-regulatesPBX1activatesR-2114-0.9954526Pr-4
RNASeq_MAFA_Calldown-regulatesPBX1activatesR-2114-0.9954526Pr-4
t(4;14)up-regulatesPBX1activatesR-2114-0.9954526Pr-4
SDK1down-regulatesPBX1activatesR-2114-0.9954526Pr-4
del13up-regulatesPBX1activatesR-2114-0.9954526Pr-4
AHNAK2down-regulatesNFKB1activatesR-1585-1.049369Pr-4
FAT3down-regulatesNFKB1activatesR-1585-1.049369Pr-4
MAXdown-regulatesNFKB1activatesR-1585-1.049369Pr-4
PTPRDdown-regulatesNFKB1activatesR-1585-1.049369Pr-4
RNASeq_MAFB_Calldown-regulatesNFKB1activatesR-1585-1.049369Pr-4
TACC2down-regulatesNFKB1activatesR-1585-1.049369Pr-4
FAT3down-regulatesNFKB2activatesR-2824-1.722958Pr-4
MAXdown-regulatesNFKB2activatesR-2824-1.722958Pr-4
RNASeq_CCND2_Calldown-regulatesNFKB2activatesR-2824-1.722958Pr-4
RNASeq_FGFR3_Calldown-regulatesNFKB2activatesR-2824-1.722958Pr-4
t(4;14)down-regulatesNFKB2activatesR-2824-1.722958Pr-4
t(4;14)_cytogeneticdown-regulatesNFKB2activatesR-2824-1.722958Pr-4
DNAH5down-regulatesRFX3activatesR-1670-1.812868Pr-4
NEBdown-regulatesRFX3activatesR-1670-1.812868Pr-4
AHNAK2up-regulatesATF1repressesR-560-1.8195323Pr-4
DCHS1up-regulatesATF1repressesR-560-1.8195323Pr-4
DIS3up-regulatesATF1repressesR-560-1.8195323Pr-4
FAM46Cdown-regulatesATF1repressesR-560-1.8195323Pr-4
MACF1up-regulatesATF1repressesR-560-1.8195323Pr-4
MAXup-regulatesATF1repressesR-560-1.8195323Pr-4
PTPRDup-regulatesATF1repressesR-560-1.8195323Pr-4
t(11;14)up-regulatesATF1repressesR-560-1.8195323Pr-4
RNASeq_MAFA_Callup-regulatesATF1repressesR-560-1.8195323Pr-4
RNASeq_MAFB_Callup-regulatesATF1repressesR-560-1.8195323Pr-4
SETD2up-regulatesATF1repressesR-560-1.8195323Pr-4
t(14;16)_cytogeneticup-regulatesATF1repressesR-560-1.8195323Pr-4
DCHS1up-regulatesNFYCrepressesR-293-1.9083216Pr-4
FAM46Cdown-regulatesNFYCrepressesR-293-1.9083216Pr-4
KALRNup-regulatesNFYCrepressesR-293-1.9083216Pr-4
NRASdown-regulatesNFYCrepressesR-293-1.9083216Pr-4
RNASeq_FGFR3_Callup-regulatesNFYCrepressesR-293-1.9083216Pr-4
RNASeq_MAFA_Callup-regulatesNFYCrepressesR-293-1.9083216Pr-4
RNASeq_MAFB_Callup-regulatesNFYCrepressesR-293-1.9083216Pr-4
t(4;14)up-regulatesNFYCrepressesR-293-1.9083216Pr-4
t(4;14)_cytogeneticup-regulatesNFYCrepressesR-293-1.9083216Pr-4
BAI3down-regulatesCREB5activatesR-773-2.0087915Pr-4
MYO10down-regulatesCREB5activatesR-773-2.0087915Pr-4
SVILdown-regulatesCREB5activatesR-773-2.0087915Pr-4
del13up-regulatesCREB5activatesR-773-2.0087915Pr-4
t(14;16)_cytogeneticdown-regulatesCREB5activatesR-773-2.0087915Pr-4
AHNAK2down-regulatesEP300activatesR-2432-2.0646212Pr-4
MAGI1down-regulatesEP300activatesR-2432-2.0646212Pr-4
TACC2down-regulatesEP300activatesR-2432-2.0646212Pr-4
del13up-regulatesEP300activatesR-2432-2.0646212Pr-4
AHNAK2down-regulatesCREB1activatesR-270-2.1391519Pr-4
FAT3down-regulatesCREB1activatesR-270-2.1391519Pr-4
MAXdown-regulatesCREB1activatesR-270-2.1391519Pr-4
del13up-regulatesCREB1activatesR-270-2.1391519Pr-4
AHNAK2up-regulatesVBP1repressesR-2099-2.1671521Pr-4
DCHS1up-regulatesVBP1repressesR-2099-2.1671521Pr-4
FAT3up-regulatesVBP1repressesR-2099-2.1671521Pr-4
MACF1up-regulatesVBP1repressesR-2099-2.1671521Pr-4
PTPRDup-regulatesVBP1repressesR-2099-2.1671521Pr-4
RNASeq_MAFA_Callup-regulatesVBP1repressesR-2099-2.1671521Pr-4
SYNE1up-regulatesVBP1repressesR-2099-2.1671521Pr-4
TACC2up-regulatesVBP1repressesR-2099-2.1671521Pr-4
del13down-regulatesVBP1repressesR-2099-2.1671521Pr-4
t(14;16)_cytogeneticup-regulatesVBP1repressesR-2099-2.1671521Pr-4
FGFR3up-regulatesCREB5activatesR-7782.183656Pr-4
SVILdown-regulatesCREB5activatesR-7782.183656Pr-4
AHNAK2down-regulatesSRFactivatesR-1778-2.2654991Pr-4
DIS3down-regulatesSRFactivatesR-1778-2.2654991Pr-4
FAM46Cup-regulatesSRFactivatesR-1778-2.2654991Pr-4
FAT3down-regulatesSRFactivatesR-1778-2.2654991Pr-4
MACF1down-regulatesSRFactivatesR-1778-2.2654991Pr-4
t(11;14)down-regulatesSRFactivatesR-1778-2.2654991Pr-4
RNASeq_FGFR3_Calldown-regulatesSRFactivatesR-1778-2.2654991Pr-4
RNASeq_MAFA_Calldown-regulatesSRFactivatesR-1778-2.2654991Pr-4
RNASeq_MAFB_Calldown-regulatesSRFactivatesR-1778-2.2654991Pr-4
t(4;14)down-regulatesSRFactivatesR-1778-2.2654991Pr-4
SETD2down-regulatesSRFactivatesR-1778-2.2654991Pr-4
SYNE1down-regulatesSRFactivatesR-1778-2.2654991Pr-4
TACC2down-regulatesSRFactivatesR-1778-2.2654991Pr-4
MAGI1down-regulatesCDC5LactivatesR-1633-2.283786Pr-4
TACC2down-regulatesCDC5LactivatesR-1633-2.283786Pr-4
del13up-regulatesCDC5LactivatesR-1633-2.283786Pr-4
NEBdown-regulatesRELactivatesR-1277-2.2901614Pr-4
TACC2down-regulatesRELactivatesR-1277-2.2901614Pr-4
AHNAK2down-regulatesRELAactivatesR-1463-2.3039915Pr-4
DCHS1down-regulatesRELAactivatesR-1463-2.3039915Pr-4
FAT3down-regulatesRELAactivatesR-1463-2.3039915Pr-4
MACF1down-regulatesRELAactivatesR-1463-2.3039915Pr-4
MYO10down-regulatesRELAactivatesR-1463-2.3039915Pr-4
NEBdown-regulatesRELAactivatesR-1463-2.3039915Pr-4
PCDH10down-regulatesRELAactivatesR-1463-2.3039915Pr-4
PTPRDdown-regulatesRELAactivatesR-1463-2.3039915Pr-4
RNASeq_MAFA_Calldown-regulatesRELAactivatesR-1463-2.3039915Pr-4
SYNE1down-regulatesRELAactivatesR-1463-2.3039915Pr-4
TACC2down-regulatesRELAactivatesR-1463-2.3039915Pr-4
del13up-regulatesRELAactivatesR-1463-2.3039915Pr-4
DIS3down-regulatesHMGA1activatesR-818-2.3158858Pr-4
FAM46Cup-regulatesHMGA1activatesR-818-2.3158858Pr-4
MAXdown-regulatesHMGA1activatesR-818-2.3158858Pr-4
NRASup-regulatesHMGA1activatesR-818-2.3158858Pr-4
RNASeq_FGFR3_Calldown-regulatesHMGA1activatesR-818-2.3158858Pr-4
RNASeq_MAFA_Calldown-regulatesHMGA1activatesR-818-2.3158858Pr-4
RNASeq_MAFB_Calldown-regulatesHMGA1activatesR-818-2.3158858Pr-4
t(4;14)down-regulatesHMGA1activatesR-818-2.3158858Pr-4
t(4;14)_cytogeneticdown-regulatesHMGA1activatesR-818-2.3158858Pr-4
AHNAK2down-regulatesIRF1activatesR-176-2.3375575Pr-4
NRASup-regulatesIRF1activatesR-176-2.3375575Pr-4
AHNAK2down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
DCHS1down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
DIS3down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
FAM46Cup-regulatesNFKB1activatesR-1573-2.3535239Pr-4
FAT3down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
MACF1down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
MAXdown-regulatesNFKB1activatesR-1573-2.3535239Pr-4
MYO10down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
PTPRDdown-regulatesNFKB1activatesR-1573-2.3535239Pr-4
RNASeq_CCND2_Calldown-regulatesNFKB1activatesR-1573-2.3535239Pr-4
RNASeq_FGFR3_Calldown-regulatesNFKB1activatesR-1573-2.3535239Pr-4
RNASeq_MAFB_Calldown-regulatesNFKB1activatesR-1573-2.3535239Pr-4
t(4;14)down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
TACC2down-regulatesNFKB1activatesR-1573-2.3535239Pr-4
t(4;14)_cytogeneticdown-regulatesNFKB1activatesR-1573-2.3535239Pr-4
DIS3up-regulatesNFYArepressesR-1468-2.3758638Pr-4
NRASdown-regulatesNFYArepressesR-1468-2.3758638Pr-4
t(11;14)up-regulatesNFYArepressesR-1468-2.37586