Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation TRIO

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
ESRRAdown-regulatesR-27470.0501381Pr-35
SP1up-regulatesR-27140.199684Pr-109
CEBPBup-regulatesR-1768-0.337185Pr-109
HMBOX1up-regulatesR-23820.378178Pr-62
SPIBup-regulatesR-6610.39364Pr-85
CEBPBup-regulatesR-17700.400611Pr-99
HINFPdown-regulatesR-2624-0.44835Pr-35
ENSG00000176887up-regulatesR-18990.507358Pr-50
MAZup-regulatesR-5070.537629Pr-129
MYBup-regulatesR-6150.668149Pr-85
PEBP1up-regulatesR-1757-0.714169Pr-41
HMBOX1up-regulatesR-2378-0.732226Pr-41
SMAD3up-regulatesR-2960-0.759716Pr-90
NFYAup-regulatesR-14790.89477Pr-129
SREBF1up-regulatesR-11370.963749Pr-87
VDRdown-regulatesR-12281.0371Pr-87
SP1up-regulatesR-27131.08118Pr-87
HMGA1down-regulatesR-8261.24266Pr-93
KLF13down-regulatesR-2041-1.31925Pr-42
SPIBup-regulatesR-6641.32468Pr-87
ATF2up-regulatesR-30911.32566Pr-41
ENSG00000176887up-regulatesR-1891-1.3829Pr-99
SMAD3up-regulatesR-29631.44668Pr-120
MZF1down-regulatesR-30171.54275Pr-85
MYBup-regulatesR-6171.6152Pr-87
ESRRAdown-regulatesR-27411.72748Pr-125
RFX7down-regulatesR-2750-1.73199Pr-118
MAZup-regulatesR-501-1.77175Pr-19
HMGA1down-regulatesR-8201.79517Pr-87
MAZup-regulatesR-4951.8487Pr-87
MYBup-regulatesR-622-1.933Pr-85
MZF1down-regulatesR-30212.2875Pr-87
HINFPdown-regulatesR-2628-2.29875Pr-42
SPIBup-regulatesR-668-2.41677Pr-90
BARX2down-regulatesR-292-2.43197Pr-101
FLI1down-regulatesR-7932.52326Pr-96
ETV2down-regulatesR-1510-2.52918Pr-36
ENSG00000176887up-regulatesR-1898-2.61611Pr-36
PEBP1up-regulatesR-17552.80711Pr-1
ETV2down-regulatesR-1507-2.80802Pr-36
ENSG00000176887up-regulatesR-19012.8972Pr-48
HINFPdown-regulatesR-2621-2.97505Pr-35
FLI1down-regulatesR-787-3.00169Pr-118
PEBP1up-regulatesR-17543.03268Pr-87
ENSG00000175832up-regulatesR-312-3.06Pr-36
FLI1down-regulatesR-780-3.11957Pr-36
SPIBup-regulatesR-6783.32159Pr-87
SP1up-regulatesR-27153.33045Pr-78

Genes (2)

STIMATE, DDOST

Regulons (6)

R-1941, R-2744, R-656, R-2715, R-2072, R-1512

MYBup-regulatesR-620-3.37541Pr-38
PEBP1up-regulatesR-1752-3.39081Pr-36
SPIBup-regulatesR-677-3.40986Pr-41
MZF1down-regulatesR-3019-3.42244Pr-35
CEBPBup-regulatesR-17593.59248Pr-108
NFYAup-regulatesR-14733.6387Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SPIBup-regulatesR-679-3.70577Pr-36
ENSG00000176887up-regulatesR-18953.70985Pr-50
CEBPBup-regulatesR-1775-3.79192Pr-36
SP1up-regulatesR-2726-3.82052Pr-20
CEBPBup-regulatesR-1774-3.92486Pr-38
SPIBup-regulatesR-6733.97206Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

SP1up-regulatesR-2734-3.98682Pr-38
MAZup-regulatesR-509-4.01621Pr-42
MYBup-regulatesR-626-4.24578Pr-36
SP1up-regulatesR-27314.29242Pr-18
SP1up-regulatesR-2735-4.34716Pr-42
ENSG00000176887up-regulatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FLI1down-regulatesR-794-4.49758Pr-36
ESRRAdown-regulatesR-2740-4.64571Pr-36
NFYAup-regulatesR-14754.71043Pr-128
MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-5045.11311Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

MYBup-regulatesR-6185.69454Pr-108
SP1up-regulatesR-2720-6.02354Pr-104
MZF1down-regulatesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

SP1up-regulatesR-27126.54886Pr-54

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions