Program

Causal Mechanistic Flows with regulons in program Pr-109

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DCHS1up-regulatesSP1activatesR-27140.19968434Pr-109
DIS3up-regulatesSP1activatesR-27140.19968434Pr-109
FAM46Cdown-regulatesSP1activatesR-27140.19968434Pr-109
FGFR3up-regulatesSP1activatesR-27140.19968434Pr-109
IRF4up-regulatesSP1activatesR-27140.19968434Pr-109
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27140.19968434Pr-109
RNASeq_MAFA_Callup-regulatesSP1activatesR-27140.19968434Pr-109
RNASeq_MAFB_Callup-regulatesSP1activatesR-27140.19968434Pr-109
t(14;16)up-regulatesSP1activatesR-27140.19968434Pr-109
t(4;14)up-regulatesSP1activatesR-27140.19968434Pr-109
TRIOup-regulatesSP1activatesR-27140.19968434Pr-109
t(4;14)_cytogeneticup-regulatesSP1activatesR-27140.19968434Pr-109
DCHS1up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
DIS3up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
FAM46Cdown-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
FGFR3up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
HUWE1up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
IRF4up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
LTBup-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
MAXup-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
NFKB2down-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
NRASdown-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
PRKD2up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
RELNup-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
t(11;14)up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
t(4;14)up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
ROBO1down-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
SETD2up-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
TRIOup-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
t(11;14)_cytogeneticup-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
t(4;14)_cytogeneticup-regulatesCEBPBactivatesR-1768-0.33718510Pr-109
ANK2down-regulatesNF1activatesR-1300.3812246Pr-109
CMYA5down-regulatesNF1activatesR-1300.3812246Pr-109
DIS3up-regulatesNF1activatesR-1300.3812246Pr-109
FAM46Cdown-regulatesNF1activatesR-1300.3812246Pr-109
FLGdown-regulatesNF1activatesR-1300.3812246Pr-109
IRF4up-regulatesNF1activatesR-1300.3812246Pr-109
KIAA1109down-regulatesNF1activatesR-1300.3812246Pr-109
LRP2down-regulatesNF1activatesR-1300.3812246Pr-109
MACF1down-regulatesNF1activatesR-1300.3812246Pr-109
RELNdown-regulatesNF1activatesR-1300.3812246Pr-109
t(11;14)up-regulatesNF1activatesR-1300.3812246Pr-109
MYCdown-regulatesNF1activatesR-1300.3812246Pr-109
t(11;14)_cytogeneticup-regulatesNF1activatesR-1300.3812246Pr-109
IRF4down-regulatesSPDEFrepressesR-1972-0.5179547Pr-109
t(11;14)down-regulatesSPDEFrepressesR-1972-0.5179547Pr-109
SETD2down-regulatesSPDEFrepressesR-1972-0.5179547Pr-109
BAI3down-regulatesSTAT4activatesR-2652-0.68759311Pr-109
DSTdown-regulatesSTAT4activatesR-2652-0.68759311Pr-109
FGFR3up-regulatesSTAT4activatesR-2652-0.68759311Pr-109
RNASeq_FGFR3_Callup-regulatesSTAT4activatesR-2652-0.68759311Pr-109
t(4;14)up-regulatesSTAT4activatesR-2652-0.68759311Pr-109
t(4;14)_cytogeneticup-regulatesSTAT4activatesR-2652-0.68759311Pr-109
CACNA1Hup-regulatesETS1repressesR-101.316376Pr-109
CYLDup-regulatesETS1repressesR-101.316376Pr-109
DSCAML1up-regulatesETS1repressesR-101.316376Pr-109
FGFR3down-regulatesETS1repressesR-101.316376Pr-109
KIAA1244up-regulatesETS1repressesR-101.316376Pr-109
KRASdown-regulatesETS1repressesR-101.316376Pr-109
NRASdown-regulatesETS1repressesR-101.316376Pr-109
PRKD2down-regulatesETS1repressesR-101.316376Pr-109
RNASeq_FGFR3_Calldown-regulatesETS1repressesR-101.316376Pr-109
RNASeq_MAFA_Callup-regulatesETS1repressesR-101.316376Pr-109
RNASeq_MAFB_Callup-regulatesETS1repressesR-101.316376Pr-109
t(14;16)up-regulatesETS1repressesR-101.316376Pr-109
t(4;14)down-regulatesETS1repressesR-101.316376Pr-109
SYNE2up-regulatesETS1repressesR-101.316376Pr-109
t(4;14)_cytogeneticdown-regulatesETS1repressesR-101.316376Pr-109
DIS3up-regulatesSATB1activatesR-1079-1.378959Pr-109
DSTdown-regulatesSATB1activatesR-1079-1.378959Pr-109
FGFR3up-regulatesSATB1activatesR-1079-1.378959Pr-109
MAXdown-regulatesSATB1activatesR-1079-1.378959Pr-109
PRKD2up-regulatesSATB1activatesR-1079-1.378959Pr-109
RNASeq_FGFR3_Callup-regulatesSATB1activatesR-1079-1.378959Pr-109
t(4;14)up-regulatesSATB1activatesR-1079-1.378959Pr-109
RYR1down-regulatesSATB1activatesR-1079-1.378959Pr-109
t(4;14)_cytogeneticup-regulatesSATB1activatesR-1079-1.378959Pr-109
AHNAK2down-regulatesGABPB1repressesR-19461.8810712Pr-109
FAT3down-regulatesGABPB1repressesR-19461.8810712Pr-109
DIS3up-regulatesTGIF1activatesR-2505-1.939186Pr-109
KMT2Bdown-regulatesTGIF1activatesR-2505-1.939186Pr-109
PRKD2up-regulatesTGIF1activatesR-2505-1.939186Pr-109
t(11;14)up-regulatesTGIF1activatesR-2505-1.939186Pr-109
RNASeq_FGFR3_Callup-regulatesTGIF1activatesR-2505-1.939186Pr-109
t(4;14)up-regulatesTGIF1activatesR-2505-1.939186Pr-109
t(11;14)_cytogeneticup-regulatesTGIF1activatesR-2505-1.939186Pr-109
t(4;14)_cytogeneticup-regulatesTGIF1activatesR-2505-1.939186Pr-109
FAM46Cdown-regulatesATF5activatesR-2405-2.170537Pr-109
FGFR3up-regulatesATF5activatesR-2405-2.170537Pr-109
t(11;14)up-regulatesATF5activatesR-2405-2.170537Pr-109
RNASeq_FGFR3_Callup-regulatesATF5activatesR-2405-2.170537Pr-109
t(4;14)up-regulatesATF5activatesR-2405-2.170537Pr-109
SETD2up-regulatesATF5activatesR-2405-2.170537Pr-109
TTNdown-regulatesATF5activatesR-2405-2.170537Pr-109
DIS3up-regulatesNFYAactivatesR-14782.178927Pr-109
FGFR3up-regulatesNFYAactivatesR-14782.178927Pr-109
t(11;14)up-regulatesNFYAactivatesR-14782.178927Pr-109
RNASeq_FGFR3_Callup-regulatesNFYAactivatesR-14782.178927Pr-109
t(4;14)up-regulatesNFYAactivatesR-14782.178927Pr-109
t(4;14)_cytogeneticup-regulatesNFYAactivatesR-14782.178927Pr-109
t(11;14)up-regulatesENSG00000245848activatesR-1654-2.44488Pr-109
MYCdown-regulatesENSG00000245848activatesR-1654-2.44488Pr-109
CMYA5up-regulatesHMGA1repressesR-830-2.656956Pr-109
DIS3down-regulatesHMGA1repressesR-830-2.656956Pr-109
FAM46Cup-regulatesHMGA1repressesR-830-2.656956Pr-109
IRF4down-regulatesHMGA1repressesR-830-2.656956Pr-109
MAXdown-regulatesHMGA1repressesR-830-2.656956Pr-109
NRASup-regulatesHMGA1repressesR-830-2.656956Pr-109
PRKD2down-regulatesHMGA1repressesR-830-2.656956Pr-109
t(11;14)down-regulatesHMGA1repressesR-830-2.656956Pr-109
RNASeq_FGFR3_Calldown-regulatesHMGA1repressesR-830-2.656956Pr-109
MYCup-regulatesHMGA1repressesR-830-2.656956Pr-109
t(4;14)down-regulatesHMGA1repressesR-830-2.656956Pr-109
t(11;14)_cytogeneticdown-regulatesHMGA1repressesR-830-2.656956Pr-109
t(4;14)_cytogeneticdown-regulatesHMGA1repressesR-830-2.656956Pr-109
FAM46Cdown-regulatesCEBPBactivatesR-1773-3.413938Pr-109
FGFR3up-regulatesCEBPBactivatesR-1773-3.413938Pr-109
NRASdown-regulatesCEBPBactivatesR-1773-3.413938Pr-109
t(11;14)up-regulatesCEBPBactivatesR-1773-3.413938Pr-109
RNASeq_FGFR3_Callup-regulatesCEBPBactivatesR-1773-3.413938Pr-109
t(4;14)up-regulatesCEBPBactivatesR-1773-3.413938Pr-109
ROBO1down-regulatesCEBPBactivatesR-1773-3.413938Pr-109
t(11;14)_cytogeneticup-regulatesCEBPBactivatesR-1773-3.413938Pr-109
t(4;14)_cytogeneticup-regulatesCEBPBactivatesR-1773-3.413938Pr-109
t(11;14)up-regulatesRARAactivatesR-170-3.988869Pr-109
SYNE1down-regulatesRARAactivatesR-170-3.988869Pr-109
del13up-regulatesRARAactivatesR-170-3.988869Pr-109
t(11;14)_cytogeneticup-regulatesRARAactivatesR-170-3.988869Pr-109

Regulons in program Pr-109

Regulon Cox Hazard Ratio # genes # causal flows
R-27140.1996843412
R-1768-0.3371851020
R-1300.381224613
R-1972-0.51795473
R-2652-0.687593116
R-101.31637615
R-1079-1.3789599
R-19461.88107122
R-2505-1.9391868
R-2405-2.1705377
R-14782.1789276
R-1654-2.444882
R-830-2.65695613
R-1773-3.4139389
R-170-3.9888694

Genes in program Pr-109

EnsEMBL IdEntrez IdPreferred
ENSG00000177239 11253MAN1B1
ENSG00000178878 81575APOLD1
ENSG00000179409 50628GEMIN4
ENSG00000181619 64582GPR135
ENSG00000184270 317772HIST2H2AB
ENSG00000197971 4155MBP
ENSG00000198455 158586ZXDB
ENSG00000219438 25817FAM19A5
ENSG00000221988 9374PPT2
ENSG00000244274 55861DBNDD2
ENSG00000247077 192111PGAM5
ENSG00000139083 2120ETV6

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions