Program

Causal Mechanistic Flows with regulons in program Pr-99

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DNAH5down-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
FAT3down-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
MYO10down-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
NEBdown-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
PTPRDdown-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
t(11;14)up-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
SVILdown-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
SYNE1down-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
TACC2down-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
del13up-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
t(14;16)_cytogeneticdown-regulatesTCF7L1repressesR-3174-0.1359536Pr-99
FAT3down-regulatesCEBPGrepressesR-453-0.1805126Pr-99
MAGI1down-regulatesCEBPGrepressesR-453-0.1805126Pr-99
SYNE1down-regulatesCEBPGrepressesR-453-0.1805126Pr-99
TACC2down-regulatesCEBPGrepressesR-453-0.1805126Pr-99
CMYA5down-regulatesCEBPBrepressesR-17700.4006119Pr-99
DIS3up-regulatesCEBPBrepressesR-17700.4006119Pr-99
FAM46Cdown-regulatesCEBPBrepressesR-17700.4006119Pr-99
FGFR3up-regulatesCEBPBrepressesR-17700.4006119Pr-99
HUWE1up-regulatesCEBPBrepressesR-17700.4006119Pr-99
IRF4up-regulatesCEBPBrepressesR-17700.4006119Pr-99
NRASdown-regulatesCEBPBrepressesR-17700.4006119Pr-99
PRKD2up-regulatesCEBPBrepressesR-17700.4006119Pr-99
t(11;14)up-regulatesCEBPBrepressesR-17700.4006119Pr-99
RNASeq_FGFR3_Callup-regulatesCEBPBrepressesR-17700.4006119Pr-99
t(4;14)up-regulatesCEBPBrepressesR-17700.4006119Pr-99
ROBO1down-regulatesCEBPBrepressesR-17700.4006119Pr-99
TRIOup-regulatesCEBPBrepressesR-17700.4006119Pr-99
del17pdown-regulatesCEBPBrepressesR-17700.4006119Pr-99
t(11;14)_cytogeneticup-regulatesCEBPBrepressesR-17700.4006119Pr-99
t(4;14)_cytogeneticup-regulatesCEBPBrepressesR-17700.4006119Pr-99
DIS3up-regulatesENSG00000165066repressesR-30830.4483787Pr-99
KDM3Bup-regulatesENSG00000165066repressesR-30830.4483787Pr-99
KLHL6down-regulatesENSG00000165066repressesR-30830.4483787Pr-99
t(11;14)up-regulatesENSG00000165066repressesR-30830.4483787Pr-99
RNASeq_FGFR3_Calldown-regulatesENSG00000165066repressesR-30830.4483787Pr-99
t(4;14)down-regulatesENSG00000165066repressesR-30830.4483787Pr-99
t(11;14)_cytogeneticup-regulatesENSG00000165066repressesR-30830.4483787Pr-99
AHNAK2down-regulatesFOXK1repressesR-1212-0.4594057Pr-99
DCHS1down-regulatesFOXK1repressesR-1212-0.4594057Pr-99
FAT3down-regulatesFOXK1repressesR-1212-0.4594057Pr-99
MYO10down-regulatesFOXK1repressesR-1212-0.4594057Pr-99
NEBdown-regulatesFOXK1repressesR-1212-0.4594057Pr-99
TACC2down-regulatesFOXK1repressesR-1212-0.4594057Pr-99
del13up-regulatesFOXK1repressesR-1212-0.4594057Pr-99
NEBdown-regulatesELK1repressesR-6480.7651539Pr-99
t(11;14)up-regulatesELK1repressesR-6480.7651539Pr-99
TACC2down-regulatesELK1repressesR-6480.7651539Pr-99
DIS3up-regulatesTGIF1repressesR-2506-0.7802366Pr-99
t(11;14)up-regulatesTGIF1repressesR-2506-0.7802366Pr-99
t(14;16)up-regulatesTGIF1repressesR-2506-0.7802366Pr-99
t(11;14)_cytogeneticup-regulatesTGIF1repressesR-2506-0.7802366Pr-99
AHNAK2down-regulatesNRF1repressesR-2709-0.7857648Pr-99
DNAH5down-regulatesNRF1repressesR-2709-0.7857648Pr-99
NEBdown-regulatesNRF1repressesR-2709-0.7857648Pr-99
t(11;14)up-regulatesNRF1repressesR-2709-0.7857648Pr-99
SDK1down-regulatesNRF1repressesR-2709-0.7857648Pr-99
t(11;14)_cytogeneticup-regulatesNRF1repressesR-2709-0.7857648Pr-99
ATMup-regulatesNFATC2repressesR-1696-1.016018Pr-99
t(14;16)up-regulatesNFATC2repressesR-1696-1.016018Pr-99
ABCA13up-regulatesZNF143activatesR-23141.049029Pr-99
FAT3up-regulatesZNF143activatesR-23141.049029Pr-99
MYCup-regulatesZNF143activatesR-23141.049029Pr-99
PCDH10up-regulatesPARP1activatesR-2642-1.094416Pr-99
PTPRDup-regulatesPARP1activatesR-2642-1.094416Pr-99
t(11;14)down-regulatesPARP1activatesR-2642-1.094416Pr-99
t(11;14)_cytogeneticdown-regulatesPARP1activatesR-2642-1.094416Pr-99
DIS3up-regulatesZBTB16repressesR-587-1.146339Pr-99
LRP2down-regulatesZBTB16repressesR-587-1.146339Pr-99
MYO10down-regulatesZBTB16repressesR-587-1.146339Pr-99
t(11;14)up-regulatesZBTB16repressesR-587-1.146339Pr-99
t(11;14)_cytogeneticup-regulatesZBTB16repressesR-587-1.146339Pr-99
BRAFdown-regulatesIRF4activatesR-492-1.327259Pr-99
DIS3down-regulatesIRF4activatesR-492-1.327259Pr-99
FAM46Cup-regulatesIRF4activatesR-492-1.327259Pr-99
IRF4down-regulatesIRF4activatesR-492-1.327259Pr-99
KIAA1244up-regulatesIRF4activatesR-492-1.327259Pr-99
MYO10up-regulatesIRF4activatesR-492-1.327259Pr-99
NEBup-regulatesIRF4activatesR-492-1.327259Pr-99
PRKD2down-regulatesIRF4activatesR-492-1.327259Pr-99
t(11;14)down-regulatesIRF4activatesR-492-1.327259Pr-99
RNASeq_FGFR3_Calldown-regulatesIRF4activatesR-492-1.327259Pr-99
t(4;14)down-regulatesIRF4activatesR-492-1.327259Pr-99
amp1qdown-regulatesIRF4activatesR-492-1.327259Pr-99
del13down-regulatesIRF4activatesR-492-1.327259Pr-99
t(11;14)_cytogeneticdown-regulatesIRF4activatesR-492-1.327259Pr-99
t(4;14)_cytogeneticdown-regulatesIRF4activatesR-492-1.327259Pr-99
BRAFup-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
DIS3up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
FAM46Cdown-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
FGFR3up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
HUWE1up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
IRF4up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
LTBup-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
NFKB2down-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
PRKD2up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
t(11;14)up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
RNASeq_FGFR3_Callup-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
t(14;16)up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
t(4;14)up-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
TRIOup-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
t(11;14)_cytogeneticup-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
t(4;14)_cytogeneticup-regulatesENSG00000176887repressesR-1891-1.382912Pr-99
t(11;14)down-regulatesXBP1activatesR-3063-1.391376Pr-99
del1pdown-regulatesXBP1activatesR-3063-1.391376Pr-99
t(11;14)_cytogeneticdown-regulatesXBP1activatesR-3063-1.391376Pr-99
NEBdown-regulatesELK1repressesR-640-1.4619714Pr-99
t(11;14)up-regulatesELK1repressesR-640-1.4619714Pr-99
t(14;16)up-regulatesELK1repressesR-640-1.4619714Pr-99
amp1qup-regulatesELK1repressesR-640-1.4619714Pr-99
del13up-regulatesELK1repressesR-640-1.4619714Pr-99
DIS3up-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
IRF4up-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
NEBdown-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
t(11;14)up-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
t(14;16)up-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
t(4;14)up-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
amp1qup-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
t(11;14)_cytogeneticup-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
t(4;14)_cytogeneticup-regulatesSTAT5ArepressesR-2162-1.4797913Pr-99
t(11;14)down-regulatesSTAT1activatesR-3070-1.5161520Pr-99
del17up-regulatesSTAT1activatesR-3070-1.5161520Pr-99
t(11;14)_cytogeneticdown-regulatesSTAT1activatesR-3070-1.5161520Pr-99
NEBdown-regulatesHBP1repressesR-1834-1.5350417Pr-99
t(11;14)up-regulatesHBP1repressesR-1834-1.5350417Pr-99
amp1qup-regulatesHBP1repressesR-1834-1.5350417Pr-99
del13up-regulatesHBP1repressesR-1834-1.5350417Pr-99
FGFR3up-regulatesIRF1repressesR-188-1.5689125Pr-99
KRASup-regulatesIRF1repressesR-188-1.5689125Pr-99
PRKD2up-regulatesIRF1repressesR-188-1.5689125Pr-99
t(11;14)up-regulatesIRF1repressesR-188-1.5689125Pr-99
RNASeq_FGFR3_Callup-regulatesIRF1repressesR-188-1.5689125Pr-99
t(14;16)up-regulatesIRF1repressesR-188-1.5689125Pr-99
t(11;14)_cytogeneticup-regulatesIRF1repressesR-188-1.5689125Pr-99
CMYA5down-regulatesELF3repressesR-2140-1.5883627Pr-99
t(11;14)up-regulatesELF3repressesR-2140-1.5883627Pr-99
amp1qup-regulatesELF3repressesR-2140-1.5883627Pr-99
del13up-regulatesELF3repressesR-2140-1.5883627Pr-99
del17down-regulatesELF3repressesR-2140-1.5883627Pr-99
del17pdown-regulatesELF3repressesR-2140-1.5883627Pr-99
SYNE1up-regulatesZNF143activatesR-2317-1.665168Pr-99
t(11;14)up-regulatesFOXJ2repressesR-1435-1.6694524Pr-99
t(14;16)up-regulatesFOXJ2repressesR-1435-1.6694524Pr-99
t(4;14)up-regulatesFOXJ2repressesR-1435-1.6694524Pr-99
amp1qup-regulatesFOXJ2repressesR-1435-1.6694524Pr-99
del13up-regulatesFOXJ2repressesR-1435-1.6694524Pr-99
t(11;14)up-regulatesFOXP1repressesR-3129-1.7374723Pr-99
t(14;16)up-regulatesFOXP1repressesR-3129-1.7374723Pr-99
amp1qup-regulatesFOXP1repressesR-3129-1.7374723Pr-99
del13up-regulatesFOXP1repressesR-3129-1.7374723Pr-99
t(11;14)_cytogeneticup-regulatesFOXP1repressesR-3129-1.7374723Pr-99
RNASeq_FGFR3_Callup-regulatesETV6repressesR-699-1.7640916Pr-99
t(14;16)up-regulatesETV6repressesR-699-1.7640916Pr-99
t(4;14)up-regulatesETV6repressesR-699-1.7640916Pr-99
amp1qup-regulatesETV6repressesR-699-1.7640916Pr-99
del13up-regulatesETV6repressesR-699-1.7640916Pr-99
t(4;14)_cytogeneticup-regulatesETV6repressesR-699-1.7640916Pr-99
NEBdown-regulatesENSG00000165702repressesR-3090-1.863846Pr-99
t(11;14)up-regulatesENSG00000165702repressesR-3090-1.863846Pr-99
t(11;14)up-regulatesELK1repressesR-6502.02468Pr-99
TACC2down-regulatesELK1repressesR-6502.02468Pr-99
del13up-regulatesELK1repressesR-6502.02468Pr-99
NEBdown-regulatesENSG00000054598repressesR-1007-2.0706623Pr-99
t(11;14)up-regulatesENSG00000054598repressesR-1007-2.0706623Pr-99
MYCdown-regulatesENSG00000054598repressesR-1007-2.0706623Pr-99
del17down-regulatesENSG00000054598repressesR-1007-2.0706623Pr-99
DMDup-regulatesBACH2repressesR-2844-3.593838Pr-99
FAT1up-regulatesBACH2repressesR-2844-3.593838Pr-99
FGFR3up-regulatesBACH2repressesR-2844-3.593838Pr-99
PRDM1up-regulatesBACH2repressesR-2844-3.593838Pr-99
RNASeq_FGFR3_Callup-regulatesBACH2repressesR-2844-3.593838Pr-99
t(14;16)up-regulatesBACH2repressesR-2844-3.593838Pr-99
t(4;14)up-regulatesBACH2repressesR-2844-3.593838Pr-99
amp1qup-regulatesBACH2repressesR-2844-3.593838Pr-99
del13up-regulatesBACH2repressesR-2844-3.593838Pr-99
t(4;14)_cytogeneticup-regulatesBACH2repressesR-2844-3.593838Pr-99
HMCN1down-regulatesZNF143activatesR-2311-4.5867310Pr-99
DMDup-regulatesARID5ArepressesR-606-4.767938Pr-99
KIAA1109up-regulatesARID5ArepressesR-606-4.767938Pr-99
NEBdown-regulatesARID5ArepressesR-606-4.767938Pr-99
t(14;16)up-regulatesARID5ArepressesR-606-4.767938Pr-99
amp1qup-regulatesARID5ArepressesR-606-4.767938Pr-99
del13up-regulatesARID5ArepressesR-606-4.767938Pr-99
del1pup-regulatesARID5ArepressesR-606-4.767938Pr-99

Regulons in program Pr-99

Regulon Cox Hazard Ratio # genes # causal flows
R-3174-0.135953611
R-453-0.18051264
R-17700.400611916
R-30830.44837877
R-1212-0.45940577
R-6480.76515393
R-2506-0.78023664
R-2709-0.78576486
R-1696-1.0160182
R-23141.0490293
R-2642-1.0944164
R-587-1.1463395
R-492-1.32725915
R-1891-1.38291216
R-3063-1.3913763
R-640-1.46197145
R-2162-1.47979139
R-3070-1.51615203
R-1834-1.53504174
R-188-1.56891257
R-2140-1.58836276
R-2317-1.6651681
R-1435-1.66945245
R-3129-1.73747235
R-699-1.76409166
R-3090-1.8638462
R-6502.024683
R-1007-2.07066234
R-2844-3.59383810
R-2311-4.58673101
R-606-4.7679387

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions