Program

Causal Mechanistic Flows with regulons in program Pr-50

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
ATMup-regulatesENSG00000176887activatesR-18990.5073586Pr-50
DCHS1up-regulatesENSG00000176887activatesR-18990.5073586Pr-50
DIS3up-regulatesENSG00000176887activatesR-18990.5073586Pr-50
t(14;16)up-regulatesENSG00000176887activatesR-18990.5073586Pr-50
TRIOup-regulatesENSG00000176887activatesR-18990.5073586Pr-50
amp1qup-regulatesENSG00000176887activatesR-18990.5073586Pr-50
AHNAK2down-regulatesFLI1repressesR-7952.776646Pr-50
DIS3down-regulatesFLI1repressesR-7952.776646Pr-50
FAM46Cup-regulatesFLI1repressesR-7952.776646Pr-50
FAT3down-regulatesFLI1repressesR-7952.776646Pr-50
IRF4down-regulatesFLI1repressesR-7952.776646Pr-50
MAXdown-regulatesFLI1repressesR-7952.776646Pr-50
NRASup-regulatesFLI1repressesR-7952.776646Pr-50
PTPRDdown-regulatesFLI1repressesR-7952.776646Pr-50
t(11;14)down-regulatesFLI1repressesR-7952.776646Pr-50
RNASeq_CCND2_Calldown-regulatesFLI1repressesR-7952.776646Pr-50
RNASeq_FGFR3_Calldown-regulatesFLI1repressesR-7952.776646Pr-50
RNASeq_MAFB_Calldown-regulatesFLI1repressesR-7952.776646Pr-50
t(14;16)down-regulatesFLI1repressesR-7952.776646Pr-50
t(4;14)down-regulatesFLI1repressesR-7952.776646Pr-50
SETD2down-regulatesFLI1repressesR-7952.776646Pr-50
TRAF3down-regulatesFLI1repressesR-7952.776646Pr-50
TTNdown-regulatesFLI1repressesR-7952.776646Pr-50
amp1qdown-regulatesFLI1repressesR-7952.776646Pr-50
del13down-regulatesFLI1repressesR-7952.776646Pr-50
t(14;16)_cytogeneticdown-regulatesFLI1repressesR-7952.776646Pr-50
t(4;14)_cytogeneticdown-regulatesFLI1repressesR-7952.776646Pr-50
MAXdown-regulatesENSG00000179348repressesR-10653.084917Pr-50
TRAF3down-regulatesENSG00000179348repressesR-10653.084917Pr-50
t(14;16)_cytogeneticdown-regulatesENSG00000179348repressesR-10653.084917Pr-50
AHNAK2down-regulatesTRAF4repressesR-30413.088617Pr-50
DCHS1down-regulatesTRAF4repressesR-30413.088617Pr-50
DIS3down-regulatesTRAF4repressesR-30413.088617Pr-50
FAT3down-regulatesTRAF4repressesR-30413.088617Pr-50
PTPRDdown-regulatesTRAF4repressesR-30413.088617Pr-50
RNASeq_FGFR3_Calldown-regulatesTRAF4repressesR-30413.088617Pr-50
RNASeq_MAFA_Calldown-regulatesTRAF4repressesR-30413.088617Pr-50
RNASeq_MAFB_Calldown-regulatesTRAF4repressesR-30413.088617Pr-50
t(4;14)down-regulatesTRAF4repressesR-30413.088617Pr-50
SVILdown-regulatesTRAF4repressesR-30413.088617Pr-50
TRAF3down-regulatesTRAF4repressesR-30413.088617Pr-50
UBR4down-regulatesTRAF4repressesR-30413.088617Pr-50
t(14;16)_cytogeneticdown-regulatesTRAF4repressesR-30413.088617Pr-50
t(4;14)_cytogeneticdown-regulatesTRAF4repressesR-30413.088617Pr-50
AHNAK2down-regulatesRORArepressesR-22763.226867Pr-50
DIS3up-regulatesPBX1activatesR-21133.408976Pr-50
FGFR3up-regulatesPBX1activatesR-21133.408976Pr-50
RNASeq_FGFR3_Callup-regulatesPBX1activatesR-21133.408976Pr-50
t(4;14)up-regulatesPBX1activatesR-21133.408976Pr-50
amp1qup-regulatesPBX1activatesR-21133.408976Pr-50
t(4;14)_cytogeneticup-regulatesPBX1activatesR-21133.408976Pr-50
FGFR3up-regulatesHMBOX1activatesR-23843.454416Pr-50
AHNAK2down-regulatesSPDEFrepressesR-19733.496597Pr-50
IRF4down-regulatesSPDEFrepressesR-19733.496597Pr-50
PTPRDdown-regulatesSPDEFrepressesR-19733.496597Pr-50
RNASeq_MAFB_Calldown-regulatesSPDEFrepressesR-19733.496597Pr-50
DIS3down-regulatesENSG00000168269repressesR-15683.706579Pr-50
FAM46Cup-regulatesENSG00000168269repressesR-15683.706579Pr-50
IRF4down-regulatesENSG00000168269repressesR-15683.706579Pr-50
PTPRDdown-regulatesENSG00000168269repressesR-15683.706579Pr-50
RNASeq_MAFB_Calldown-regulatesENSG00000168269repressesR-15683.706579Pr-50
TTNdown-regulatesENSG00000168269repressesR-15683.706579Pr-50
DCHS1up-regulatesENSG00000176887activatesR-18953.709859Pr-50
DIS3up-regulatesENSG00000176887activatesR-18953.709859Pr-50
FAM46Cdown-regulatesENSG00000176887activatesR-18953.709859Pr-50
FAT3up-regulatesENSG00000176887activatesR-18953.709859Pr-50
FGFR3up-regulatesENSG00000176887activatesR-18953.709859Pr-50
IRF4up-regulatesENSG00000176887activatesR-18953.709859Pr-50
RNASeq_FGFR3_Callup-regulatesENSG00000176887activatesR-18953.709859Pr-50
t(14;16)up-regulatesENSG00000176887activatesR-18953.709859Pr-50
t(4;14)up-regulatesENSG00000176887activatesR-18953.709859Pr-50
TRIOup-regulatesENSG00000176887activatesR-18953.709859Pr-50
amp1qup-regulatesENSG00000176887activatesR-18953.709859Pr-50
t(4;14)_cytogeneticup-regulatesENSG00000176887activatesR-18953.709859Pr-50
AHNAK2down-regulatesEWSR1repressesR-25543.7261511Pr-50
CMYA5down-regulatesEWSR1repressesR-25543.7261511Pr-50
MACF1down-regulatesEWSR1repressesR-25543.7261511Pr-50
NEBdown-regulatesEWSR1repressesR-25543.7261511Pr-50
PCDH10down-regulatesEWSR1repressesR-25543.7261511Pr-50
t(11;14)up-regulatesEWSR1repressesR-25543.7261511Pr-50
RNASeq_MAFB_Calldown-regulatesEWSR1repressesR-25543.7261511Pr-50
TACC2down-regulatesEWSR1repressesR-25543.7261511Pr-50
AHNAK2down-regulatesGABPB1repressesR-19513.936688Pr-50
FAT3down-regulatesGABPB1repressesR-19513.936688Pr-50
PTPRDdown-regulatesGABPB1repressesR-19513.936688Pr-50
AHNAK2down-regulatesELF1repressesR-29834.0960714Pr-50
NRASup-regulatesELF1repressesR-29834.0960714Pr-50
t(11;14)up-regulatesELF1repressesR-29834.0960714Pr-50
TRAF3down-regulatesELF1repressesR-29834.0960714Pr-50
ANK2up-regulatesZNF143activatesR-23244.099256Pr-50
DCHS1up-regulatesZNF143activatesR-23244.099256Pr-50
FAT3up-regulatesZNF143activatesR-23244.099256Pr-50
NRASdown-regulatesZNF143activatesR-23244.099256Pr-50
t(14;16)_cytogeneticup-regulatesZNF143activatesR-23244.099256Pr-50
FGFR3up-regulatesENSG00000136574activatesR-384.61996Pr-50
RNASeq_FGFR3_Callup-regulatesENSG00000136574activatesR-384.61996Pr-50
t(4;14)up-regulatesENSG00000136574activatesR-384.61996Pr-50
t(4;14)_cytogeneticup-regulatesENSG00000136574activatesR-384.61996Pr-50
SYNE1down-regulatesENSG00000179348repressesR-10684.675786Pr-50
TRAF3down-regulatesENSG00000179348repressesR-10684.675786Pr-50
t(14;16)_cytogeneticdown-regulatesENSG00000179348repressesR-10684.675786Pr-50
LRP1Bdown-regulatesBCL6repressesR-5374.8426922Pr-50
PCDH15up-regulatesBCL6repressesR-5374.8426922Pr-50
t(11;14)up-regulatesBCL6repressesR-5374.8426922Pr-50
t(14;16)_cytogeneticdown-regulatesBCL6repressesR-5374.8426922Pr-50

Regulons in program Pr-50

Regulon Cox Hazard Ratio # genes # causal flows
R-18990.50735866
R-7952.77664621
R-10653.0849173
R-30413.08861714
R-22763.2268671
R-21133.4089766
R-23843.4544161
R-19733.4965974
R-15683.7065796
R-18953.70985912
R-25543.72615118
R-19513.9366883
R-29834.09607144
R-23244.0992565
R-384.619964
R-10684.6757863
R-5374.84269224

Genes in program Pr-50

EnsEMBL IdEntrez IdPreferred
ENSG00000181458 55076TMEM45A

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions