Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ARID5B - AT-rich interaction domain 5B

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
84159 ENSG00000150347 ARID5B Q14865

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ARID5B

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
ASXL3ARID5BactivatesR-1095-1.32163Pr-0
amp1qARID5BactivatesR-1095-1.32163Pr-0
del13ARID5BactivatesR-1095-1.32163Pr-0
HUWE1ARID5BactivatesR-1097-2.32805Pr-100
t(11;14)ARID5BactivatesR-1097-2.32805Pr-100
FGFR3ARID5BactivatesR-10982.61489Pr-122
RNASeq_FGFR3_CallARID5BactivatesR-10982.61489Pr-122
t(4;14)ARID5BactivatesR-10982.61489Pr-122
t(4;14)_cytogeneticARID5BactivatesR-10982.61489Pr-122
MYCARID5BrepressesR-10967.71326Pr-68
TP53ARID5BrepressesR-10967.71326Pr-68

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.