Program

Causal Mechanistic Flows with regulons in program Pr-128

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesFOXK1repressesR-12000.35365512Pr-128
RNASeq_MAFA_Calldown-regulatesFOXK1repressesR-12000.35365512Pr-128
FAT3up-regulatesENSG00000176887activatesR-18930.37037711Pr-128
IRF4up-regulatesENSG00000176887activatesR-18930.37037711Pr-128
PRKD2up-regulatesENSG00000176887activatesR-18930.37037711Pr-128
t(11;14)up-regulatesENSG00000176887activatesR-18930.37037711Pr-128
t(4;14)up-regulatesENSG00000176887activatesR-18930.37037711Pr-128
t(11;14)_cytogeneticup-regulatesENSG00000176887activatesR-18930.37037711Pr-128
FAT3up-regulatesPARP1activatesR-26410.4176946Pr-128
NRASdown-regulatesPARP1activatesR-26410.4176946Pr-128
t(4;14)up-regulatesPARP1activatesR-26410.4176946Pr-128
MYCdown-regulatesMAFBrepressesR-17390.56625312Pr-128
DIS3up-regulatesJUNactivatesR-11832.842998Pr-128
MUC16down-regulatesJUNactivatesR-11832.842998Pr-128
t(11;14)up-regulatesJUNactivatesR-11832.842998Pr-128
ROBO1down-regulatesJUNactivatesR-11832.842998Pr-128
t(11;14)_cytogeneticup-regulatesJUNactivatesR-11832.842998Pr-128
PRKD2down-regulatesCUX1repressesR-12463.350179Pr-128
RNASeq_FGFR3_Calldown-regulatesCUX1repressesR-12463.350179Pr-128
t(4;14)down-regulatesCUX1repressesR-12463.350179Pr-128
amp1qdown-regulatesCUX1repressesR-12463.350179Pr-128
DIS3up-regulatesENSG00000165066activatesR-30813.734778Pr-128
FAT3up-regulatesENSG00000165066activatesR-30813.734778Pr-128
IRF4up-regulatesENSG00000165066activatesR-30813.734778Pr-128
t(11;14)up-regulatesENSG00000165066activatesR-30813.734778Pr-128
TP53up-regulatesENSG00000165066activatesR-30813.734778Pr-128
t(11;14)_cytogeneticup-regulatesENSG00000165066activatesR-30813.734778Pr-128
DIS3down-regulatesHOXA3repressesR-2254.129627Pr-128
FAM46Cup-regulatesHOXA3repressesR-2254.129627Pr-128
HUWE1down-regulatesHOXA3repressesR-2254.129627Pr-128
IRF4down-regulatesHOXA3repressesR-2254.129627Pr-128
KLHL6up-regulatesHOXA3repressesR-2254.129627Pr-128
PRKD2down-regulatesHOXA3repressesR-2254.129627Pr-128
t(11;14)down-regulatesHOXA3repressesR-2254.129627Pr-128
RNASeq_FGFR3_Calldown-regulatesHOXA3repressesR-2254.129627Pr-128
RNASeq_MAFB_Calldown-regulatesHOXA3repressesR-2254.129627Pr-128
t(14;16)down-regulatesHOXA3repressesR-2254.129627Pr-128
t(4;14)down-regulatesHOXA3repressesR-2254.129627Pr-128
ROBO2down-regulatesHOXA3repressesR-2254.129627Pr-128
t(11;14)_cytogeneticdown-regulatesHOXA3repressesR-2254.129627Pr-128
t(4;14)_cytogeneticdown-regulatesHOXA3repressesR-2254.129627Pr-128
AHNAK2down-regulatesMEF2ArepressesR-18804.4609418Pr-128
DCHS1down-regulatesMEF2ArepressesR-18804.4609418Pr-128
DIS3down-regulatesMEF2ArepressesR-18804.4609418Pr-128
FAM46Cup-regulatesMEF2ArepressesR-18804.4609418Pr-128
FAT3down-regulatesMEF2ArepressesR-18804.4609418Pr-128
MACF1down-regulatesMEF2ArepressesR-18804.4609418Pr-128
MAXdown-regulatesMEF2ArepressesR-18804.4609418Pr-128
NRASup-regulatesMEF2ArepressesR-18804.4609418Pr-128
RNASeq_CCND2_Calldown-regulatesMEF2ArepressesR-18804.4609418Pr-128
RNASeq_FGFR3_Calldown-regulatesMEF2ArepressesR-18804.4609418Pr-128
RNASeq_MAFA_Calldown-regulatesMEF2ArepressesR-18804.4609418Pr-128
RNASeq_MAFB_Calldown-regulatesMEF2ArepressesR-18804.4609418Pr-128
t(4;14)down-regulatesMEF2ArepressesR-18804.4609418Pr-128
SETD2down-regulatesMEF2ArepressesR-18804.4609418Pr-128
t(14;16)_cytogeneticdown-regulatesMEF2ArepressesR-18804.4609418Pr-128
DIS3up-regulatesNFYAactivatesR-14754.7104311Pr-128
FGFR3up-regulatesNFYAactivatesR-14754.7104311Pr-128
NRASdown-regulatesNFYAactivatesR-14754.7104311Pr-128
t(11;14)up-regulatesNFYAactivatesR-14754.7104311Pr-128
RNASeq_FGFR3_Callup-regulatesNFYAactivatesR-14754.7104311Pr-128
t(4;14)up-regulatesNFYAactivatesR-14754.7104311Pr-128
TRIOup-regulatesNFYAactivatesR-14754.7104311Pr-128
t(4;14)_cytogeneticup-regulatesNFYAactivatesR-14754.7104311Pr-128
FAT3down-regulatesPOU2F1repressesR-904.8099917Pr-128
MACF1down-regulatesPOU2F1repressesR-904.8099917Pr-128

Regulons in program Pr-128

Regulon Cox Hazard Ratio # genes # causal flows
R-12000.353655122
R-18930.370377116
R-26410.41769463
R-17390.566253121
R-11832.8429985
R-12463.3501794
R-30813.7347786
R-2254.12962714
R-18804.460941815
R-14754.71043118
R-904.80999172

Genes in program Pr-128

EnsEMBL IdEntrez IdPreferred
ENSG00000179133 256815C10orf67
ENSG00000179335 1198CLK3
ENSG00000179988 118672PSTK
ENSG00000182240

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions