Program – Multiple Myeloma Network Portal

Causal Mechanistic Flows with regulons in program Pr-95

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
ATM	up-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
NRAS	down-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
RNASeq_MAFA_Call	up-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(14;16)	up-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
ROBO2	up-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
amp1q	up-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
del13	up-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(14;16)_cytogenetic	up-regulates	DR1	activates	R-45	-0.00173773	6	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
amp1q	up-regulates	ELF2	activates	R-984	0.272388	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
del13	up-regulates	ELF2	activates	R-984	0.272388	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
ATM	up-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
CACNA1H	up-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
NRAS	down-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
RNASeq_MAFA_Call	up-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
RNASeq_MAFB_Call	up-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(14;16)	up-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
SYNE2	up-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
TRAF3	up-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
ZNF208	down-regulates	ETS1	activates	R-5	-0.284036	8	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
DIS3	up-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
FAM46C	down-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
RNASeq_FGFR3_Call	up-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(14;16)	up-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(4;14)	up-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
amp1q	up-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
del13	up-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(4;14)_cytogenetic	up-regulates	ZFX	activates	R-1928	0.481402	7	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
RNASeq_MAFA_Call	up-regulates	ARID5A	activates	R-600	-1.16018	11	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
t(14;16)	up-regulates	ARID5A	activates	R-600	-1.16018	11	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
amp1q	up-regulates	ARID5A	activates	R-600	-1.16018	11	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
del13	up-regulates	ARID5A	activates	R-600	-1.16018	11	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
del1p	up-regulates	ARID5A	activates	R-600	-1.16018	11	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600

Regulons in program Pr-95

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-45	-0.00173773	6	8
R-984	0.272388	8	2
R-5	-0.284036	8	9
R-1928	0.481402	7	8
R-600	-1.16018	11	5

Genes in program Pr-95

EnsEMBL Id	Entrez Id	Preferred
ENSG00000175390	8665	EIF3F
ENSG00000177981	140461	ASB8
ENSG00000178127	4729	NDUFV2
ENSG00000181038	124512	METTL23
ENSG00000196743	2760	GM2A

Pr-95

Program 95

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Program Survival Plots