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Causal Mechanistic Flows with regulons in program Pr-23

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Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
AHNAK2	down-regulates	ELF4	activates	R-2344	0.524718	15	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
AHNAK2	down-regulates	FOXJ3	activates	R-2889	0.679009	16	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
AHNAK2	down-regulates	CEBPG	activates	R-444	1.22162	10	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
amp1q	up-regulates	PRDM1	activates	R-2081	-0.107496	10	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
amp1q	up-regulates	MEF2A	activates	R-1884	0.142343	15	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
amp1q	up-regulates	HBP1	activates	R-1839	0.37241	10	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
amp1q	up-regulates	BACH1	activates	R-477	0.551978	6	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
amp1q	up-regulates	FOXJ3	activates	R-2889	0.679009	16	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
amp1q	up-regulates	STAT3	activates	R-309	0.879665	8	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
amp1q	down-regulates	TP53	represses	R-371	0.918717	10	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444

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Regulons in program Pr-23

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Regulon	Cox Hazard Ratio	# genes	# causal flows
R-3190	0.592808	11	5
R-2889	0.679009	16	6
R-2732	0.411833	15	1
R-2344	0.524718	15	5
R-2182	-0.40215	11	5
R-2081	-0.107496	10	3
R-1884	0.142343	15	3
R-1839	0.37241	10	5
R-1719	-0.189674	6	1
R-1274	0.404038	6	2

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Genes in program Pr-23

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EnsEMBL Id	Entrez Id	Preferred
ENSG00000176204	80059	LRRTM4
ENSG00000176619	84823	LMNB2
ENSG00000177191	374907	B3GNT8
ENSG00000179344	3119	HLA-DQB1
ENSG00000179886	84948	TIGD5
ENSG00000179902
ENSG00000179943	84922	FIZ1
ENSG00000181744	205428	C3orf58
ENSG00000182158	64764	CREB3L2
ENSG00000182858	79087	ALG12

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