Program

Causal Mechanistic Flows with regulons in program Pr-23

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(14;16)up-regulatesPRDM1activatesR-2081-0.10749610Pr-23
amp1qup-regulatesPRDM1activatesR-2081-0.10749610Pr-23
del13up-regulatesPRDM1activatesR-2081-0.10749610Pr-23
TACC2down-regulatesMEF2AactivatesR-18840.14234315Pr-23
amp1qup-regulatesMEF2AactivatesR-18840.14234315Pr-23
del13up-regulatesMEF2AactivatesR-18840.14234315Pr-23
EYSup-regulatesNR4A2activatesR-1719-0.1896746Pr-23
PCDH10down-regulatesHBP1activatesR-18390.3724110Pr-23
t(11;14)up-regulatesHBP1activatesR-18390.3724110Pr-23
TACC2down-regulatesHBP1activatesR-18390.3724110Pr-23
amp1qup-regulatesHBP1activatesR-18390.3724110Pr-23
del13up-regulatesHBP1activatesR-18390.3724110Pr-23
BAI3down-regulatesSOX4activatesR-2182-0.4021511Pr-23
KDM3Bdown-regulatesSOX4activatesR-2182-0.4021511Pr-23
t(11;14)down-regulatesSOX4activatesR-2182-0.4021511Pr-23
del13up-regulatesSOX4activatesR-2182-0.4021511Pr-23
t(11;14)_cytogeneticdown-regulatesSOX4activatesR-2182-0.4021511Pr-23
t(11;14)down-regulatesZBTB3repressesR-12740.4040386Pr-23
del13down-regulatesZBTB3repressesR-12740.4040386Pr-23
TRAF3up-regulatesSP1repressesR-27320.41183315Pr-23
AHNAK2down-regulatesELF4activatesR-23440.52471815Pr-23
BAI3down-regulatesELF4activatesR-23440.52471815Pr-23
PRDM1up-regulatesELF4activatesR-23440.52471815Pr-23
t(14;16)up-regulatesELF4activatesR-23440.52471815Pr-23
TRAF3down-regulatesELF4activatesR-23440.52471815Pr-23
BRAFup-regulatesBACH1activatesR-4770.5519786Pr-23
t(11;14)up-regulatesBACH1activatesR-4770.5519786Pr-23
t(14;16)up-regulatesBACH1activatesR-4770.5519786Pr-23
amp1qup-regulatesBACH1activatesR-4770.5519786Pr-23
del13up-regulatesBACH1activatesR-4770.5519786Pr-23
PCDH10down-regulatesNR3C1activatesR-31900.59280811Pr-23
RNASeq_CCND2_Calldown-regulatesNR3C1activatesR-31900.59280811Pr-23
RNASeq_MAFA_Callup-regulatesNR3C1activatesR-31900.59280811Pr-23
t(14;16)up-regulatesNR3C1activatesR-31900.59280811Pr-23
del13up-regulatesNR3C1activatesR-31900.59280811Pr-23
AHNAK2down-regulatesFOXJ3activatesR-28890.67900916Pr-23
BRAFup-regulatesFOXJ3activatesR-28890.67900916Pr-23
KRASup-regulatesFOXJ3activatesR-28890.67900916Pr-23
TACC2down-regulatesFOXJ3activatesR-28890.67900916Pr-23
amp1qup-regulatesFOXJ3activatesR-28890.67900916Pr-23
del13up-regulatesFOXJ3activatesR-28890.67900916Pr-23
t(14;16)up-regulatesSTAT3activatesR-3090.8796658Pr-23
TACC2down-regulatesSTAT3activatesR-3090.8796658Pr-23
amp1qup-regulatesSTAT3activatesR-3090.8796658Pr-23
del13up-regulatesSTAT3activatesR-3090.8796658Pr-23
t(14;16)down-regulatesTP53repressesR-3710.91871710Pr-23
amp1qdown-regulatesTP53repressesR-3710.91871710Pr-23
del13down-regulatesTP53repressesR-3710.91871710Pr-23
AHNAK2down-regulatesCEBPGactivatesR-4441.2216210Pr-23
PCDH10down-regulatesCEBPGactivatesR-4441.2216210Pr-23
amp1qup-regulatesCEBPGactivatesR-4441.2216210Pr-23
del13up-regulatesCEBPGactivatesR-4441.2216210Pr-23

Regulons in program Pr-23

Regulon Cox Hazard Ratio # genes # causal flows
R-2081-0.107496103
R-18840.142343153
R-1719-0.18967461
R-18390.37241105
R-2182-0.40215115
R-12740.40403862
R-27320.411833151
R-23440.524718155
R-4770.55197865
R-31900.592808115
R-28890.679009166
R-3090.87966584
R-3710.918717103
R-4441.22162104

Genes in program Pr-23

EnsEMBL IdEntrez IdPreferred
ENSG00000176204 80059LRRTM4
ENSG00000176619 84823LMNB2
ENSG00000177191 374907B3GNT8
ENSG00000179344 3119HLA-DQB1
ENSG00000179886 84948TIGD5
ENSG00000179902
ENSG00000179943 84922FIZ1
ENSG00000181744 205428C3orf58
ENSG00000182158 64764CREB3L2
ENSG00000182858 79087ALG12
ENSG00000184113
ENSG00000186470 11118BTN3A2
ENSG00000187097 957ENTPD5
ENSG00000197226 23061TBC1D9B

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions