Program

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

Causal Mechanistic Flows with regulons in program Pr-57

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(14;16)_cytogeneticdown-regulatesENSG00000179348activatesR-10590.021369512Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

DIS3up-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

FGFR3up-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

LTBup-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

NRASdown-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

RNASeq_FGFR3_Callup-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

t(4;14)up-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

amp1qup-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

del13up-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

t(4;14)_cytogeneticup-regulatesPBX1activatesR-21080.49611714Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

DIS3up-regulatesTGIF1activatesR-24991.108419Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

RNASeq_FGFR3_Callup-regulatesTGIF1activatesR-24991.108419Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

t(4;14)up-regulatesTGIF1activatesR-24991.108419Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

t(4;14)_cytogeneticup-regulatesTGIF1activatesR-24991.108419Pr-57

Genes (3)

UCP2, ZNF746, IARS

Regulons (3)

R-1059, R-2108, R-2499

Regulons in program Pr-57

Regulon Cox Hazard Ratio # genes # causal flows
R-10590.0213695121
R-21080.496117149
R-24991.1084194

Genes in program Pr-57

EnsEMBL IdEntrez IdPreferred
ENSG00000175567 7351UCP2
ENSG00000181220 155061ZNF746
ENSG00000196305 3376IARS

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions