Causal Mechanistic Flows with regulons in program Pr-57
| Mutation | Role | Regulator | Role | Regulon | Hazard Ratio | # regulon genes | Transcriptional Program |
|---|---|---|---|---|---|---|---|
| t(14;16)_cytogenetic | down-regulates | ENSG00000179348 | activates | R-1059 | 0.0213695 | 12 | Pr-57 |
| DIS3 | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| FGFR3 | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| LTB | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| NRAS | down-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| RNASeq_FGFR3_Call | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| t(4;14) | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| amp1q | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| del13 | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| t(4;14)_cytogenetic | up-regulates | PBX1 | activates | R-2108 | 0.496117 | 14 | Pr-57 |
| DIS3 | up-regulates | TGIF1 | activates | R-2499 | 1.10841 | 9 | Pr-57 |
| RNASeq_FGFR3_Call | up-regulates | TGIF1 | activates | R-2499 | 1.10841 | 9 | Pr-57 |
| t(4;14) | up-regulates | TGIF1 | activates | R-2499 | 1.10841 | 9 | Pr-57 |
| t(4;14)_cytogenetic | up-regulates | TGIF1 | activates | R-2499 | 1.10841 | 9 | Pr-57 |
Genes in program Pr-57
| EnsEMBL Id | Entrez Id | Preferred |
|---|---|---|
| ENSG00000175567 | 7351 | UCP2 |
| ENSG00000181220 | 155061 | ZNF746 |
| ENSG00000196305 | 3376 | IARS |
