Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SREBF1 - sterol regulatory element binding transcription factor 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6720 ENSG00000072310 SREBF1 J3QLB6

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: SREBF1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
ATMSREBF1activatesR-11390.101608Pr-7
MACF1SREBF1activatesR-11390.101608Pr-7
t(11;14)SREBF1activatesR-11390.101608Pr-7
RNASeq_MAFA_CallSREBF1activatesR-11390.101608Pr-7
RNASeq_MAFB_CallSREBF1activatesR-11390.101608Pr-7
t(14;16)SREBF1activatesR-11390.101608Pr-7
amp1qSREBF1activatesR-11390.101608Pr-7
del13SREBF1activatesR-11390.101608Pr-7
del1pSREBF1activatesR-11390.101608Pr-7
AHNAK2SREBF1activatesR-11370.963749Pr-87
ATMSREBF1activatesR-11370.963749Pr-87
DIS3SREBF1activatesR-11370.963749Pr-87
DNAH9SREBF1activatesR-11370.963749Pr-87
FLGSREBF1activatesR-11370.963749Pr-87
MACF1SREBF1activatesR-11370.963749Pr-87
NRASSREBF1activatesR-11370.963749Pr-87
PTPRDSREBF1activatesR-11370.963749Pr-87
RNASeq_FGFR3_CallSREBF1activatesR-11370.963749Pr-87
RNASeq_MAFA_CallSREBF1activatesR-11370.963749Pr-87
RNASeq_MAFB_CallSREBF1activatesR-11370.963749Pr-87
t(14;16)SREBF1activatesR-11370.963749Pr-87
t(4;14)SREBF1activatesR-11370.963749Pr-87
ROBO2SREBF1activatesR-11370.963749Pr-87
SYNE2SREBF1activatesR-11370.963749Pr-87
TRIOSREBF1activatesR-11370.963749Pr-87
amp1qSREBF1activatesR-11370.963749Pr-87
del13SREBF1activatesR-11370.963749Pr-87
t(14;16)_cytogeneticSREBF1activatesR-11370.963749Pr-87
t(4;14)_cytogeneticSREBF1activatesR-11370.963749Pr-87
ATMSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

MACF1SREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PTPRDSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_CallSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_CallSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFB_CallSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)SREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)SREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

amp1qSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

del13SREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

del1pSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)_cytogeneticSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)_cytogeneticSREBF1activatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

CSMD1SREBF1activatesR-1136-2.84396Pr-86
NRASSREBF1activatesR-1136-2.84396Pr-86
RNASeq_MAFA_CallSREBF1activatesR-1136-2.84396Pr-86
RNASeq_MAFB_CallSREBF1activatesR-1136-2.84396Pr-86
t(14;16)SREBF1activatesR-1136-2.84396Pr-86
amp1qSREBF1activatesR-1136-2.84396Pr-86
del13SREBF1activatesR-1136-2.84396Pr-86
del1pSREBF1activatesR-1136-2.84396Pr-86
t(14;16)_cytogeneticSREBF1activatesR-1136-2.84396Pr-86
DIS3SREBF1repressesR-1138-5.22607Pr-104
IRF4SREBF1repressesR-1138-5.22607Pr-104
t(11;14)SREBF1repressesR-1138-5.22607Pr-104
RNASeq_MAFA_CallSREBF1repressesR-1138-5.22607Pr-104
RNASeq_MAFB_CallSREBF1repressesR-1138-5.22607Pr-104
t(14;16)SREBF1repressesR-1138-5.22607Pr-104
t(11;14)_cytogeneticSREBF1repressesR-1138-5.22607Pr-104

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.