Program

Causal Mechanistic Flows with regulons in program Pr-89

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DCHS1up-regulatesSP1activatesR-27300.10220515Pr-89
DIS3up-regulatesSP1activatesR-27300.10220515Pr-89
RNASeq_MAFA_Callup-regulatesSP1activatesR-27300.10220515Pr-89
RNASeq_MAFB_Callup-regulatesSP1activatesR-27300.10220515Pr-89
t(14;16)up-regulatesSP1activatesR-27300.10220515Pr-89
t(4;14)up-regulatesSP1activatesR-27300.10220515Pr-89
ROBO2up-regulatesSP1activatesR-27300.10220515Pr-89
TRAF3up-regulatesSP1activatesR-27300.10220515Pr-89
t(14;16)_cytogeneticup-regulatesSP1activatesR-27300.10220515Pr-89
NRASup-regulatesCEBPZrepressesR-754-1.92157Pr-89
t(11;14)down-regulatesCEBPZrepressesR-754-1.92157Pr-89
MYCup-regulatesCEBPZrepressesR-754-1.92157Pr-89
DIS3up-regulatesYY1activatesR-2526-2.051539Pr-89
MPDZdown-regulatesYY1activatesR-2526-2.051539Pr-89
RNASeq_MAFA_Callup-regulatesYY1activatesR-2526-2.051539Pr-89
t(4;14)up-regulatesYY1activatesR-2526-2.051539Pr-89
DCHS1down-regulatesELF3repressesR-2146-2.0974514Pr-89
KALRNdown-regulatesELF3repressesR-2146-2.0974514Pr-89
DCHS1down-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
DIS3down-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
FAM46Cup-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
KALRNdown-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
NRASup-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
RNASeq_MAFA_Calldown-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
RNASeq_MAFB_Calldown-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
t(4;14)down-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
t(14;16)_cytogeneticdown-regulatesMEF2ArepressesR-1885-2.0986515Pr-89
DIS3down-regulatesKLF16repressesR-2702-2.581387Pr-89
KIAA1109up-regulatesKLF16repressesR-2702-2.581387Pr-89
NRASup-regulatesKLF16repressesR-2702-2.581387Pr-89
t(11;14)down-regulatesKLF16repressesR-2702-2.581387Pr-89
ROBO1up-regulatesKLF16repressesR-2702-2.581387Pr-89
t(11;14)_cytogeneticdown-regulatesKLF16repressesR-2702-2.581387Pr-89
t(14;16)_cytogeneticdown-regulatesBCL6repressesR-545-2.6553614Pr-89

Regulons in program Pr-89

Regulon Cox Hazard Ratio # genes # causal flows
R-27300.102205159
R-754-1.921573
R-2526-2.0515394
R-2146-2.09745142
R-1885-2.09865159
R-2702-2.5813876
R-545-2.65536141

Genes in program Pr-89

EnsEMBL IdEntrez IdPreferred
ENSG00000176155 284001CCDC57
ENSG00000221926 147166TRIM16L
ENSG00000237441 5863RGL2
ENSG00000241127 57002YAE1D1
ENSG00000241258 27297CRCP

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions