Program

Causal Mechanistic Flows with regulons in program Pr-88

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FGFR3up-regulatesRUNX3activatesR-9000.1839447Pr-88
PRDM1up-regulatesRUNX3activatesR-9000.1839447Pr-88
RNASeq_FGFR3_Callup-regulatesRUNX3activatesR-9000.1839447Pr-88
t(14;16)up-regulatesRUNX3activatesR-9000.1839447Pr-88
MAXdown-regulatesIRF4repressesR-4910.36590210Pr-88
RNASeq_FGFR3_Calldown-regulatesIRF4repressesR-4910.36590210Pr-88
t(4;14)down-regulatesIRF4repressesR-4910.36590210Pr-88
amp1qdown-regulatesIRF4repressesR-4910.36590210Pr-88
del13down-regulatesIRF4repressesR-4910.36590210Pr-88
t(4;14)_cytogeneticdown-regulatesIRF4repressesR-4910.36590210Pr-88
t(14;16)up-regulatesRUNX3activatesR-8930.4416315Pr-88
ATMup-regulatesMAFactivatesR-1020.46835618Pr-88
FAM46Cdown-regulatesMAFactivatesR-1020.46835618Pr-88
FAT2up-regulatesMAFactivatesR-1020.46835618Pr-88
NRASdown-regulatesMAFactivatesR-1020.46835618Pr-88
RELNup-regulatesMAFactivatesR-1020.46835618Pr-88
RNASeq_MAFA_Callup-regulatesMAFactivatesR-1020.46835618Pr-88
RNASeq_MAFB_Callup-regulatesMAFactivatesR-1020.46835618Pr-88
t(14;16)up-regulatesMAFactivatesR-1020.46835618Pr-88
ROBO1down-regulatesMAFactivatesR-1020.46835618Pr-88
SYNE2up-regulatesMAFactivatesR-1020.46835618Pr-88
amp1qup-regulatesMAFactivatesR-1020.46835618Pr-88
t(14;16)_cytogeneticup-regulatesMAFactivatesR-1020.46835618Pr-88
RNASeq_FGFR3_Calldown-regulatesCUX1repressesR-12470.4799257Pr-88
t(4;14)down-regulatesCUX1repressesR-12470.4799257Pr-88
amp1qdown-regulatesCUX1repressesR-12470.4799257Pr-88
MACF1down-regulatesHINFPrepressesR-2627-0.487126Pr-88
NRASup-regulatesHINFPrepressesR-2627-0.487126Pr-88
RNASeq_MAFA_Calldown-regulatesHINFPrepressesR-2627-0.487126Pr-88
RNASeq_MAFB_Calldown-regulatesHINFPrepressesR-2627-0.487126Pr-88
t(14;16)down-regulatesHINFPrepressesR-2627-0.487126Pr-88
TRAF3down-regulatesHINFPrepressesR-2627-0.487126Pr-88
TTNdown-regulatesHINFPrepressesR-2627-0.487126Pr-88
amp1qdown-regulatesHINFPrepressesR-2627-0.487126Pr-88
t(14;16)_cytogeneticdown-regulatesHINFPrepressesR-2627-0.487126Pr-88
DNAH5down-regulatesIRX3repressesR-2234-0.5760426Pr-88
RNASeq_MAFA_Calldown-regulatesIRX3repressesR-2234-0.5760426Pr-88
SYNE1down-regulatesIRX3repressesR-2234-0.5760426Pr-88
t(14;16)_cytogeneticdown-regulatesIRX3repressesR-2234-0.5760426Pr-88
DIS3up-regulatesCEBPEactivatesR-26840.7626411Pr-88
DNAH10up-regulatesCEBPEactivatesR-26840.7626411Pr-88
HIST1H1Edown-regulatesCEBPEactivatesR-26840.7626411Pr-88
RNASeq_FGFR3_Callup-regulatesCEBPEactivatesR-26840.7626411Pr-88
del1pup-regulatesCEBPEactivatesR-26840.7626411Pr-88
RNASeq_MAFA_Callup-regulatesFOXP1activatesR-31381.161912Pr-88
t(14;16)up-regulatesFOXP1activatesR-31381.161912Pr-88
amp1qup-regulatesFOXP1activatesR-31381.161912Pr-88
del13up-regulatesFOXP1activatesR-31381.161912Pr-88
del1pup-regulatesFOXP1activatesR-31381.161912Pr-88
DIS3down-regulatesTP53repressesR-3681.3802511Pr-88
MAXdown-regulatesTP53repressesR-3681.3802511Pr-88
NRASup-regulatesTP53repressesR-3681.3802511Pr-88
RNASeq_FGFR3_Calldown-regulatesTP53repressesR-3681.3802511Pr-88
t(14;16)down-regulatesTP53repressesR-3681.3802511Pr-88
MYCup-regulatesTP53repressesR-3681.3802511Pr-88
t(4;14)down-regulatesTP53repressesR-3681.3802511Pr-88
amp1qdown-regulatesTP53repressesR-3681.3802511Pr-88
del13down-regulatesTP53repressesR-3681.3802511Pr-88
t(4;14)_cytogeneticdown-regulatesTP53repressesR-3681.3802511Pr-88
RNASeq_FGFR3_Calldown-regulatesSPI1activatesR-2620-1.4689912Pr-88
MYCdown-regulatesSPI1activatesR-2620-1.4689912Pr-88
t(4;14)down-regulatesSPI1activatesR-2620-1.4689912Pr-88
ATMup-regulatesMAFactivatesR-1041.4904416Pr-88
DIS3up-regulatesMAFactivatesR-1041.4904416Pr-88
FAT1up-regulatesMAFactivatesR-1041.4904416Pr-88
FAT2up-regulatesMAFactivatesR-1041.4904416Pr-88
MUC17up-regulatesMAFactivatesR-1041.4904416Pr-88
NRASdown-regulatesMAFactivatesR-1041.4904416Pr-88
RELNup-regulatesMAFactivatesR-1041.4904416Pr-88
t(11;14)down-regulatesMAFactivatesR-1041.4904416Pr-88
RNASeq_MAFA_Callup-regulatesMAFactivatesR-1041.4904416Pr-88
RNASeq_MAFB_Callup-regulatesMAFactivatesR-1041.4904416Pr-88
t(14;16)up-regulatesMAFactivatesR-1041.4904416Pr-88
t(4;14)up-regulatesMAFactivatesR-1041.4904416Pr-88
ROBO1down-regulatesMAFactivatesR-1041.4904416Pr-88
SYNE2up-regulatesMAFactivatesR-1041.4904416Pr-88
amp1qup-regulatesMAFactivatesR-1041.4904416Pr-88
del13up-regulatesMAFactivatesR-1041.4904416Pr-88
t(11;14)_cytogeneticdown-regulatesMAFactivatesR-1041.4904416Pr-88
t(14;16)_cytogeneticup-regulatesMAFactivatesR-1041.4904416Pr-88
t(4;14)_cytogeneticup-regulatesMAFactivatesR-1041.4904416Pr-88
ATMup-regulatesNFATC2activatesR-1690-1.6147716Pr-88
CSMD1up-regulatesNFATC2activatesR-1690-1.6147716Pr-88
KLHL6down-regulatesNFATC2activatesR-1690-1.6147716Pr-88
NRASdown-regulatesNFATC2activatesR-1690-1.6147716Pr-88
RNASeq_MAFA_Callup-regulatesNFATC2activatesR-1690-1.6147716Pr-88
RNASeq_MAFB_Callup-regulatesNFATC2activatesR-1690-1.6147716Pr-88
t(14;16)up-regulatesNFATC2activatesR-1690-1.6147716Pr-88
amp1qup-regulatesNFATC2activatesR-1690-1.6147716Pr-88
del1pup-regulatesNFATC2activatesR-1690-1.6147716Pr-88
t(14;16)_cytogeneticup-regulatesNFATC2activatesR-1690-1.6147716Pr-88
KALRNdown-regulatesFOXK1repressesR-1206-1.779919Pr-88
RNASeq_MAFA_Calldown-regulatesFOXK1repressesR-1206-1.779919Pr-88
t(4;14)up-regulatesFOXK1repressesR-1206-1.779919Pr-88
del13up-regulatesFOXK1repressesR-1206-1.779919Pr-88
RNASeq_MAFA_Callup-regulatesFOXP1activatesR-31423.106678Pr-88
t(14;16)up-regulatesFOXP1activatesR-31423.106678Pr-88
amp1qup-regulatesFOXP1activatesR-31423.106678Pr-88
del1pup-regulatesFOXP1activatesR-31423.106678Pr-88
RNASeq_FGFR3_Callup-regulatesSTAT4activatesR-26603.333886Pr-88
RNASeq_MAFA_Callup-regulatesSTAT4activatesR-26603.333886Pr-88
t(14;16)up-regulatesSTAT4activatesR-26603.333886Pr-88
t(4;14)up-regulatesSTAT4activatesR-26603.333886Pr-88
SP140up-regulatesSTAT4activatesR-26603.333886Pr-88
t(4;14)_cytogeneticup-regulatesSTAT4activatesR-26603.333886Pr-88

Regulons in program Pr-88

Regulon Cox Hazard Ratio # genes # causal flows
R-9000.18394474
R-4910.365902106
R-8930.44163151
R-1020.4683561812
R-12470.47992573
R-2627-0.4871269
R-2234-0.57604264
R-26840.76264115
R-31381.1619125
R-3681.380251110
R-2620-1.46899123
R-1041.490441619
R-1690-1.614771610
R-1206-1.7799194
R-31423.1066784
R-26603.3338866

Genes in program Pr-88

EnsEMBL IdEntrez IdPreferred
ENSG00000177181
ENSG00000179271 90480GADD45GIP1
ENSG00000180370 5062PAK2
ENSG00000180902 728294D2HGDH
ENSG00000181026 64782AEN
ENSG00000181192 55526DHTKD1
ENSG00000182359 143879KBTBD3
ENSG00000185088 51065RPS27L
ENSG00000196776 961CD47
ENSG00000198466 84914ZNF587
ENSG00000198879 57713SFMBT2
ENSG00000198924 9937DCLRE1A
ENSG00000204852 79600TCTN1
ENSG00000213999 100271849MEF2B

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions