Program

Causal Mechanistic Flows with regulons in program Pr-74

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
MXRA5down-regulatesPOU2F2repressesR-25142.334911Pr-74
AHNAK2down-regulatesELF1repressesR-29862.9817110Pr-74
DSTdown-regulatesELF1repressesR-29862.9817110Pr-74
TRAF3down-regulatesELF1repressesR-29862.9817110Pr-74
AHNAK2down-regulatesETV6repressesR-7123.488319Pr-74
FGFR3up-regulatesKLF4repressesR-27593.566196Pr-74
KDM3Bdown-regulatesKLF4repressesR-27593.566196Pr-74
KMT2Bdown-regulatesKLF4repressesR-27593.566196Pr-74
RNASeq_FGFR3_Callup-regulatesKLF4repressesR-27593.566196Pr-74
MYCdown-regulatesKLF4repressesR-27593.566196Pr-74
t(4;14)up-regulatesKLF4repressesR-27593.566196Pr-74
del13up-regulatesKLF4repressesR-27593.566196Pr-74
t(4;14)_cytogeneticup-regulatesKLF4repressesR-27593.566196Pr-74
NRASdown-regulatesKLF7repressesR-2853.901228Pr-74
MYCdown-regulatesKLF7repressesR-2853.901228Pr-74
TP53down-regulatesKLF7repressesR-2853.901228Pr-74
ZNF462down-regulatesKLF7repressesR-2853.901228Pr-74
RNASeq_MAFA_Calldown-regulatesETV5repressesR-3433.988617Pr-74
t(14;16)down-regulatesETV5repressesR-3433.988617Pr-74
MYCdown-regulatesETV5repressesR-3433.988617Pr-74
SDK1down-regulatesETV5repressesR-3433.988617Pr-74
ZNF462down-regulatesETV5repressesR-3433.988617Pr-74
MACF1down-regulatesIKZF1repressesR-9954.169748Pr-74
PTPRDdown-regulatesSPI1repressesR-26154.2345716Pr-74
t(11;14)up-regulatesSPI1repressesR-26154.2345716Pr-74
MYCdown-regulatesSPI1repressesR-26154.2345716Pr-74
TRAF3down-regulatesSPI1repressesR-26154.2345716Pr-74
t(14;16)_cytogeneticdown-regulatesSPI1repressesR-26154.2345716Pr-74
AHNAK2down-regulatesELF2repressesR-9754.9643811Pr-74
DCHS1down-regulatesELF2repressesR-9754.9643811Pr-74
FAT3down-regulatesELF2repressesR-9754.9643811Pr-74
MACF1down-regulatesELF2repressesR-9754.9643811Pr-74
TACC2down-regulatesELF2repressesR-9754.9643811Pr-74

Regulons in program Pr-74

Regulon Cox Hazard Ratio # genes # causal flows
R-25142.3349111
R-29862.98171103
R-7123.4883191
R-27593.5661968
R-2853.9012284
R-3433.9886175
R-9954.1697481
R-26154.23457165
R-9754.96438115

Genes in program Pr-74

EnsEMBL IdEntrez IdPreferred
ENSG00000258102 643246MAP1LC3B2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions